Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive
Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. H...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2017-09, Vol.93, p.62-69 |
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| creator | Hakkou, Zineb Maciuk, Alexandre Leblais, Veronique Bouanani, Nour Elhouda Mekhfi, Hassane Bnouham, Mohammed Aziz, Mohammed Ziyyat, Abderrahime Rauf, Abdur Hadda, Taibi Ben Shaheen, Usama Patel, Seema Fischmeister, Rodolphe Legssyer, Abdelkhaleq |
| description | Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design. |
| doi_str_mv | 10.1016/j.biopha.2017.06.015 |
| format | Article |
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This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2017.06.015</identifier><identifier>PMID: 28623784</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Animals ; Antihypertensive Agents - pharmacology ; Blood Pressure - drug effects ; Cardiology and cardiovascular system ; Chlorogenic acid ; Chlorogenic Acid - pharmacology ; Cinnamates - pharmacology ; Cynarin ; Human health and pathology ; Hypertension ; Hypertension - drug therapy ; Internal Medicine ; Inula - chemistry ; Inula viscosa ; Life Sciences ; Medical Education ; Medicine, Traditional - methods ; Methanol - chemistry ; Methanolic extract ; NG-Nitroarginine Methyl Ester - pharmacology ; Petra/Osiris/Molinspiration (POM) analysis ; Pharmaceutical sciences ; Pharmacology ; Phytochemicals - pharmacology ; Phytotherapy - methods ; Plant Extracts - pharmacology ; Plants, Medicinal - chemistry ; Rats ; Rats, Wistar ; Vasodilatator ; Vasodilator Agents - pharmacology</subject><ispartof>Biomedicine & pharmacotherapy, 2017-09, Vol.93, p.62-69</ispartof><rights>Elsevier Masson SAS</rights><rights>2017 Elsevier Masson SAS</rights><rights>Copyright © 2017 Elsevier Masson SAS. 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This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design.</description><subject>Animals</subject><subject>Antihypertensive Agents - pharmacology</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiology and cardiovascular system</subject><subject>Chlorogenic acid</subject><subject>Chlorogenic Acid - pharmacology</subject><subject>Cinnamates - pharmacology</subject><subject>Cynarin</subject><subject>Human health and pathology</subject><subject>Hypertension</subject><subject>Hypertension - drug therapy</subject><subject>Internal Medicine</subject><subject>Inula - chemistry</subject><subject>Inula viscosa</subject><subject>Life Sciences</subject><subject>Medical Education</subject><subject>Medicine, Traditional - methods</subject><subject>Methanol - chemistry</subject><subject>Methanolic extract</subject><subject>NG-Nitroarginine Methyl Ester - pharmacology</subject><subject>Petra/Osiris/Molinspiration (POM) analysis</subject><subject>Pharmaceutical sciences</subject><subject>Pharmacology</subject><subject>Phytochemicals - pharmacology</subject><subject>Phytotherapy - methods</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal - chemistry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Vasodilatator</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks9uEzEQxlcIREPhDRDyESQS_GftzXJAChWllYKKBJytWe9s4-DYqb27Ik_FK9bblApxwZeRRt98M57fFMVLRheMMvVuu2hs2G9gwSmrFlQtKJOPihmrJZ0rSqvHxYxWUsyF4PykeJbSllIqlVg-LU74UnFRLctZ8Xvle7s57DH26JMdkYBvyQgptNZBHyLBrkPTJxI6ssN-Az44awj-6iOYfspe-sEBGW0yIQF5Tz7a4MK1NeAIjuAG6G3wd7Zfr77kCO6Q7J2fOXiI1r8lZuNCDNfoszMY2xJIZB_yRL3NLn-P97x40oFL-OI-nhY_zj99P7uYr68-X56t1nNT1lU_V7JRHQOUaFR-iHUF0pimrUGqTlCkbds2rVQlqKphlMucEY3oStGJuqzFafHm6LsBp_fR7iAedACrL1ZrPeUoLytWMjmyrH191O5juBkw9XqXl4HOgccwJM1qxjjlQkzS8ig1MaQUsXvwZlRPWPVWH7HqCaumSmesuezVfYeh2WH7UPSHYxZ8OAow72S0GHUyFr3B1sZMT7fB_q_DvwbGWT9B_IkHTNswxAwu_0Unrqn-Np3WdFmsEoxWvBK3hojOJQ</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Hakkou, Zineb</creator><creator>Maciuk, Alexandre</creator><creator>Leblais, Veronique</creator><creator>Bouanani, Nour Elhouda</creator><creator>Mekhfi, Hassane</creator><creator>Bnouham, Mohammed</creator><creator>Aziz, Mohammed</creator><creator>Ziyyat, Abderrahime</creator><creator>Rauf, Abdur</creator><creator>Hadda, Taibi Ben</creator><creator>Shaheen, Usama</creator><creator>Patel, Seema</creator><creator>Fischmeister, Rodolphe</creator><creator>Legssyer, Abdelkhaleq</creator><general>Elsevier Masson SAS</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><orcidid>https://orcid.org/0000-0003-2429-5491</orcidid><orcidid>https://orcid.org/0000-0003-2086-9865</orcidid></search><sort><creationdate>20170901</creationdate><title>Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive</title><author>Hakkou, Zineb ; Maciuk, Alexandre ; Leblais, Veronique ; Bouanani, Nour Elhouda ; Mekhfi, Hassane ; Bnouham, Mohammed ; Aziz, Mohammed ; Ziyyat, Abderrahime ; Rauf, Abdur ; Hadda, Taibi Ben ; Shaheen, Usama ; Patel, Seema ; Fischmeister, Rodolphe ; Legssyer, Abdelkhaleq</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-65b6f1ae5ec6666ee97a5ccbd9a56f30e0dddbd564a67b1025e0d3b3f43f39493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antihypertensive Agents - pharmacology</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiology and cardiovascular system</topic><topic>Chlorogenic acid</topic><topic>Chlorogenic Acid - pharmacology</topic><topic>Cinnamates - pharmacology</topic><topic>Cynarin</topic><topic>Human health and pathology</topic><topic>Hypertension</topic><topic>Hypertension - drug therapy</topic><topic>Internal Medicine</topic><topic>Inula - chemistry</topic><topic>Inula viscosa</topic><topic>Life Sciences</topic><topic>Medical Education</topic><topic>Medicine, Traditional - methods</topic><topic>Methanol - chemistry</topic><topic>Methanolic extract</topic><topic>NG-Nitroarginine Methyl Ester - pharmacology</topic><topic>Petra/Osiris/Molinspiration (POM) analysis</topic><topic>Pharmaceutical sciences</topic><topic>Pharmacology</topic><topic>Phytochemicals - pharmacology</topic><topic>Phytotherapy - methods</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal - chemistry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Vasodilatator</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hakkou, Zineb</creatorcontrib><creatorcontrib>Maciuk, Alexandre</creatorcontrib><creatorcontrib>Leblais, Veronique</creatorcontrib><creatorcontrib>Bouanani, Nour Elhouda</creatorcontrib><creatorcontrib>Mekhfi, Hassane</creatorcontrib><creatorcontrib>Bnouham, Mohammed</creatorcontrib><creatorcontrib>Aziz, Mohammed</creatorcontrib><creatorcontrib>Ziyyat, Abderrahime</creatorcontrib><creatorcontrib>Rauf, Abdur</creatorcontrib><creatorcontrib>Hadda, Taibi Ben</creatorcontrib><creatorcontrib>Shaheen, Usama</creatorcontrib><creatorcontrib>Patel, Seema</creatorcontrib><creatorcontrib>Fischmeister, Rodolphe</creatorcontrib><creatorcontrib>Legssyer, Abdelkhaleq</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hakkou, Zineb</au><au>Maciuk, Alexandre</au><au>Leblais, Veronique</au><au>Bouanani, Nour Elhouda</au><au>Mekhfi, Hassane</au><au>Bnouham, Mohammed</au><au>Aziz, Mohammed</au><au>Ziyyat, Abderrahime</au><au>Rauf, Abdur</au><au>Hadda, Taibi Ben</au><au>Shaheen, Usama</au><au>Patel, Seema</au><au>Fischmeister, Rodolphe</au><au>Legssyer, Abdelkhaleq</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2017-09-01</date><risdate>2017</risdate><volume>93</volume><spage>62</spage><epage>69</epage><pages>62-69</pages><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>28623784</pmid><doi>10.1016/j.biopha.2017.06.015</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-2429-5491</orcidid><orcidid>https://orcid.org/0000-0003-2086-9865</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Biomedicine & pharmacotherapy, 2017-09, Vol.93, p.62-69 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Antihypertensive Agents - pharmacology Blood Pressure - drug effects Cardiology and cardiovascular system Chlorogenic acid Chlorogenic Acid - pharmacology Cinnamates - pharmacology Cynarin Human health and pathology Hypertension Hypertension - drug therapy Internal Medicine Inula - chemistry Inula viscosa Life Sciences Medical Education Medicine, Traditional - methods Methanol - chemistry Methanolic extract NG-Nitroarginine Methyl Ester - pharmacology Petra/Osiris/Molinspiration (POM) analysis Pharmaceutical sciences Pharmacology Phytochemicals - pharmacology Phytotherapy - methods Plant Extracts - pharmacology Plants, Medicinal - chemistry Rats Rats, Wistar Vasodilatator Vasodilator Agents - pharmacology |
| title | Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive |
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