Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa : Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive

Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. H...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2017-09, Vol.93, p.62-69
Hauptverfasser:	Hakkou, Zineb, Maciuk, Alexandre, Leblais, Veronique, Bouanani, Nour Elhouda, Mekhfi, Hassane, Bnouham, Mohammed, Aziz, Mohammed, Ziyyat, Abderrahime, Rauf, Abdur, Hadda, Taibi Ben, Shaheen, Usama, Patel, Seema, Fischmeister, Rodolphe, Legssyer, Abdelkhaleq
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - pharmacology Blood Pressure - drug effects Cardiology and cardiovascular system Chlorogenic acid Chlorogenic Acid - pharmacology Cinnamates - pharmacology Cynarin Human health and pathology Hypertension Hypertension - drug therapy Internal Medicine Inula - chemistry Inula viscosa Life Sciences Medical Education Medicine, Traditional - methods Methanol - chemistry Methanolic extract NG-Nitroarginine Methyl Ester - pharmacology Petra/Osiris/Molinspiration (POM) analysis Pharmaceutical sciences Pharmacology Phytochemicals - pharmacology Phytotherapy - methods Plant Extracts - pharmacology Plants, Medicinal - chemistry Rats Rats, Wistar Vasodilatator Vasodilator Agents - pharmacology
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Zusammenfassung:	Graphical abstract The tested methanolic extract of Inula viscosa decreased hypertension induced in rats by L-NAME treatment. This antihypertensive effect may be partly due to the vasorelaxant effect of MeOH-extract, through the actions of two of its phenolic compounds, cynarin and chlogenic acid. However other compounds would certainly be involved in this effect. POM analysis is affirmative in chlorogenic and cynarin acids as potential models for cardiovascular drug design.
ISSN:	0753-3322 1950-6007
DOI:	10.1016/j.biopha.2017.06.015