Artemisinin and its derivatives target mitochondrial c-type cytochromes in yeast and human cells

Artemisinin and its derivatives kill malaria parasites and inhibit the proliferation of cancer cells. In both processes, heme was shown to play a key role in artemisinin bioactivation. We found that artemisinin and clinical artemisinin derivatives are able to compensate for a mutation in the yeast B...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2020-05, Vol.1867 (5), p.118661-118661, Article 118661
Hauptverfasser:	Laleve, Anais, Panozzo, Cristina, Kühl, Inge, Bourand-Plantefol, Alexa, Ostojic, Jelena, Sissoko, Abdoulaye, Tribouillard-Tanvier, Déborah, Cornu, David, Burg, Angélique, Meunier, Brigitte, Blondel, Marc, Clain, Jerome, Bonnefoy, Nathalie, Duval, Romain, Dujardin, Geneviève
Format:	Artikel
Sprache:	eng
Schlagworte:	Artemisinins Bcs1 c-Type cytochromes Fluorescent probe Life Sciences Mitochondria
Online-Zugang:	Volltext
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