Macrophage-Derived IL1β and TNFα Regulate Arginine Metabolism in Neuroblastoma

Neuroblastoma is the most common childhood solid tumor, yet the prognosis for high-risk disease remains poor. We demonstrate here that arginase 2 (ARG2) drives neuroblastoma cell proliferation via regulation of arginine metabolism. Targeting arginine metabolism, either by blocking cationic amino aci...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2019-02, Vol.79 (3), p.611-624
Hauptverfasser:	Fultang, Livingstone, Gamble, Laura D, Gneo, Luciana, Berry, Andrea M, Egan, Sharon A, De Bie, Fenna, Yogev, Orli, Eden, Georgina L, Booth, Sarah, Brownhill, Samantha, Vardon, Ashley, McConville, Carmel M, Cheng, Paul N, Norris, Murray D, Etchevers, Heather C, Murray, Jayne, Ziegler, David S, Chesler, Louis, Schmidt, Ronny, Burchill, Susan A, Haber, Michelle, De Santo, Carmela, Mussai, Francis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arginase - metabolism Arginine - metabolism Cell Line, Tumor Genetics Humans Interleukin-1beta - immunology Interleukin-1beta - metabolism Life Sciences Macrophages - immunology Macrophages - metabolism Macrophages - pathology MAP Kinase Signaling System Mice Mice, Transgenic Myeloid Cells - immunology Myeloid Cells - metabolism Myeloid Cells - pathology Neuroblastoma - immunology Neuroblastoma - metabolism Neuroblastoma - pathology Sarcoma, Ewing - immunology Sarcoma, Ewing - metabolism Sarcoma, Ewing - pathology Tumor Microenvironment Tumor Necrosis Factor-alpha - immunology Tumor Necrosis Factor-alpha - metabolism
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