Combined and differential effects of alpha‐thalassemia and HbF‐quantitative trait loci in Senegalese hydroxyurea‐free children with sickle cell anemia

Background Our objective was to investigate the combined and differential effects of alpha‐thalassemia –3.7 kb deletion and HbF‐promoting quantitative trait loci (HbF‐QTL) in Senegalese hydroxyurea (HU)‐free children and young adults with sickle cell anemia (SCA). Procedure Steady‐state biological p...

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Veröffentlicht in:	Pediatric blood & cancer 2019-10, Vol.66 (10), p.e27934-n/a
Hauptverfasser:	Gueye Tall, Fatou, Martin, Cyril, Ndour, El Hadji Malick, Renoux, Céline, Ly, Indou Déme, Connes, Philippe, Gueye, Papa Madieye, Diallo, Rokhaya Ndiaye, Diagne, Ibrahima, Diop, Pape Amadou, Cissé, Aynina, Lopez Sall, Philomène, Joly, Philippe
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Thalassemia - genetics alpha‐thalassemia Anemia Anemia, Sickle Cell - genetics Child Children Clonal deletion Cognitive science Female Fetal Hemoglobin - genetics G6PD deficiency Gene deletion Gene loci Gene mapping genetic modifiers Genotype Genotypes HbF QTL Hematology Hemoglobin H - genetics Humans Hydroxyurea Leukocytes Male Oncology Pediatrics Quantitative Trait Loci Senegal Senegal haplotype Sickle cell anemia Sickle cell disease Thalassemia VOCs Volatile organic compounds Young adults
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