A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

[7-[3-(1,3-Benzodioxol-5-yl)propyl]-2-(2-furyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine] (LZ37) was identified as a selective inhibitor of in vitro bovine viral diarrhea virus (BVDV) replication. The EC 50 values for inhibition of BVDV-induced cytopathic effect (CPE) formation, vir...

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Veröffentlicht in:	Antiviral research 2009-06, Vol.82 (3), p.141-147
Hauptverfasser:	Paeshuyse, Jan, Letellier, Carine, Froeyen, Matheus, Dutartre, Hélène, Vrancken, Robert, Canard, Bruno, De Clercq, Erik, Gueiffier, Alain, Teulade, Jean-Claude, Herdewijn, Piet, Puerstinger, Gerhard, Koenen, Frank, Kerkhofs, Pierre, Baraldi, Pier Giovanni, Neyts, Johan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution - genetics Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Benzodioxoles - chemistry Benzodioxoles - pharmacology Biological and medical sciences Bovine viral diarrhea virus Cattle Cell Line Diarrhea Virus 1, Bovine Viral - drug effects Diarrhea Virus 1, Bovine Viral - physiology Diarrhea Virus 2, Bovine Viral - drug effects Diarrhea Virus 2, Bovine Viral - physiology Drug Resistance, Viral Flavivirus Hepacivirus - drug effects Hepatitis C virus Inhibitor Inhibitory Concentration 50 Life Sciences Medical sciences Microbiology and Parasitology Models, Molecular Mutation, Missense Pestivirus Pharmacology. Drug treatments Pyrazolotriazolopyrimidinamine RNA Replicase - chemistry RNA Replicase - genetics RNA-dependent RNA polymerase Triazoles - chemistry Triazoles - pharmacology Viral Proteins - genetics Virology Virus Replication - drug effects Yellow fever virus - drug effects
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