BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers
Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients...
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| Veröffentlicht in: | The European respiratory journal 2015-05, Vol.45 (5), p.1403-1414 |
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| creator | Couraud, Sébastien Souquet, Pierre-Jean Paris, Christophe Dô, Pascal Doubre, Hélène Pichon, Eric Dixmier, Adrien Monnet, Isabelle Etienne-Mastroianni, Bénédicte Vincent, Michel Trédaniel, Jean Perrichon, Marielle Foucher, Pascal Coudert, Bruno Moro-Sibilot, Denis Dansin, Eric Labonne, Stéphanie Missy, Pascale Morin, Franck Blanché, Hélène Zalcman, Gérard |
| description | Lung cancer in never-smokers (LCINS) (fewer than 100 cigarettes in lifetime) is considered as a distinct entity and harbours an original molecular profile. However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%). |
| doi_str_mv | 10.1183/09031936.00097214 |
| format | Article |
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However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. 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However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. 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However, the epidemiological and molecular features of LCINS in Europe remain poorly understood. All consecutive newly diagnosed LCINS patients were included in this prospective observational study by 75 participating centres during a 14-month period. Each patient completed a detailed questionnaire about risk factor exposure. Biomarker and pathological analyses were also collected. We report the main descriptive overall results with a focus on sex differences. 384 patients were included: 65 men and 319 women. 66% had been exposed to passive smoking (significantly higher among women). Definite exposure to main occupational carcinogens was significantly higher in men (35% versus 8% in women). A targetable molecular alteration was found in 73% of patients (without any significant sex difference): EGFR in 51%, ALK in 8%, KRAS in 6%, HER2 in 3%, BRAF in 3%, PI3KCA in less than 1%, and multiple in 2%. We present the largest and most comprehensive LCINS analysis in a European population. Physicians should track occupational exposure in men (35%), and a somatic molecular alteration in both sexes (73%).</abstract><cop>England</cop><pub>European Respiratory Society</pub><pmid>25657019</pmid><doi>10.1183/09031936.00097214</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6417-4980</orcidid><orcidid>https://orcid.org/0000-0003-2115-575X</orcidid><orcidid>https://orcid.org/0000-0002-7025-4343</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0903-1936 |
| ispartof | The European respiratory journal, 2015-05, Vol.45 (5), p.1403-1414 |
| issn | 0903-1936 1399-3003 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02456986v1 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Biomarkers - metabolism Carcinogens Cohort Studies Female France Genetic Predisposition to Disease Humans Life Sciences Lung Neoplasms - epidemiology Lung Neoplasms - genetics Male Middle Aged Nuclear Proteins - genetics Occupational Diseases - epidemiology Occupational Diseases - genetics Occupational Exposure Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Receptor Protein-Tyrosine Kinases - genetics Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - genetics Risk Factors Santé publique et épidémiologie Sex Factors Smoking Statistics Surveys and Questionnaires Tobacco Smoke Pollution Transcription Factors - genetics |
| title | BioCAST/IFCT-1002: epidemiological and molecular features of lung cancer in never-smokers |
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