Welding and the risk of head and neck cancer: the ICARE study
ObjectiveTo investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study.MethodsAnalyses were restricted to men...
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| Veröffentlicht in: | Occupational and environmental medicine (London, England) England), 2020-05, Vol.77 (5), p.293-300 |
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| creator | Barul, Christine Matrat, Mireille Auguste, Aviane Dugas, Julien Radoï, Loredana Menvielle, Gwenn Févotte, Joëlle Guizard, Anne-Valérie Stücker, Isabelle Luce, Danièle |
| description | ObjectiveTo investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study.MethodsAnalyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.ResultsWelding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend |
| doi_str_mv | 10.1136/oemed-2019-106080 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02453456v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2390058548</sourcerecordid><originalsourceid>FETCH-LOGICAL-b443t-74e285dec0ce02435612c879f2cf94b368da385d11d7fb1313d71e39a6684f753</originalsourceid><addsrcrecordid>eNqNkF1LwzAUQIMobk5_gC9S8EmwmpvPRvBhjOmEgSCKjyFtUvfZzqYV9u9N181nnxJuzj2Eg9Al4DsAKu5Lt3Y2JhhUDFjgBB-hPjCJY6mIOA53yiHGEqCHzrxfYAxUUnKKehQUV4ImffT46VZ2XnxFprBRPXNRNffLqMyjmTN2NyxctowyU2SuetgRL6Ph2zjydWO35-gkNyvvLvbnAH08jd9Hk3j6-hywaZwyRutYMkcSbl2GM4cJo1wAyRKpcpLliqVUJNbQAABYmadAgVoJjiojRMJyyekA3XTemVnpTTVfm2qrSzPXk-FUt7Ng5ZRx8QOBve7YTVV-N87XelE2VRG-pwlVGPOEsyRQ0FFZVXpfufxPC1i3cfUurm7j6i5u2Lnam5u0fTtsHGoG4LYD0vXiH75fUQt_YA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2390058548</pqid></control><display><type>article</type><title>Welding and the risk of head and neck cancer: the ICARE study</title><source>JSTOR Archive Collection A-Z Listing</source><creator>Barul, Christine ; Matrat, Mireille ; Auguste, Aviane ; Dugas, Julien ; Radoï, Loredana ; Menvielle, Gwenn ; Févotte, Joëlle ; Guizard, Anne-Valérie ; Stücker, Isabelle ; Luce, Danièle</creator><creatorcontrib>Barul, Christine ; Matrat, Mireille ; Auguste, Aviane ; Dugas, Julien ; Radoï, Loredana ; Menvielle, Gwenn ; Févotte, Joëlle ; Guizard, Anne-Valérie ; Stücker, Isabelle ; Luce, Danièle ; ICARE study group</creatorcontrib><description>ObjectiveTo investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study.MethodsAnalyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.ResultsWelding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer.ConclusionOur findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.</description><identifier>ISSN: 1351-0711</identifier><identifier>EISSN: 1470-7926</identifier><identifier>DOI: 10.1136/oemed-2019-106080</identifier><identifier>PMID: 31959638</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Acids ; Alcohol ; Arc welding ; Asbestos ; Cancer ; Ecology, environment ; Head & neck cancer ; Health ; Hypopharynx ; Interviews ; Job titles ; Laryngeal cancer ; Larynx ; Life Sciences ; Metal workers ; Occupational exposure ; Occupational health ; Occupations ; Oral cancer ; Oral cavity ; Oropharynx ; Population studies ; Questionnaires ; Regression analysis ; Risk ; Santé publique et épidémiologie ; Smoking ; Spot welding ; Stainless steel ; Studies ; Tobacco ; Tobacco smoking ; Welding ; Working hours</subject><ispartof>Occupational and environmental medicine (London, England), 2020-05, Vol.77 (5), p.293-300</ispartof><rights>Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2020 Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b443t-74e285dec0ce02435612c879f2cf94b368da385d11d7fb1313d71e39a6684f753</citedby><cites>FETCH-LOGICAL-b443t-74e285dec0ce02435612c879f2cf94b368da385d11d7fb1313d71e39a6684f753</cites><orcidid>0000-0001-9252-2612 ; 0000-0002-1708-4584 ; 0000-0002-3195-8348 ; 0000-0002-3261-6366</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31959638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://univ-rennes.hal.science/hal-02453456$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Barul, Christine</creatorcontrib><creatorcontrib>Matrat, Mireille</creatorcontrib><creatorcontrib>Auguste, Aviane</creatorcontrib><creatorcontrib>Dugas, Julien</creatorcontrib><creatorcontrib>Radoï, Loredana</creatorcontrib><creatorcontrib>Menvielle, Gwenn</creatorcontrib><creatorcontrib>Févotte, Joëlle</creatorcontrib><creatorcontrib>Guizard, Anne-Valérie</creatorcontrib><creatorcontrib>Stücker, Isabelle</creatorcontrib><creatorcontrib>Luce, Danièle</creatorcontrib><creatorcontrib>ICARE study group</creatorcontrib><title>Welding and the risk of head and neck cancer: the ICARE study</title><title>Occupational and environmental medicine (London, England)</title><addtitle>Occup Environ Med</addtitle><description>ObjectiveTo investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study.MethodsAnalyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.ResultsWelding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer.ConclusionOur findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.</description><subject>Acids</subject><subject>Alcohol</subject><subject>Arc welding</subject><subject>Asbestos</subject><subject>Cancer</subject><subject>Ecology, environment</subject><subject>Head & neck cancer</subject><subject>Health</subject><subject>Hypopharynx</subject><subject>Interviews</subject><subject>Job titles</subject><subject>Laryngeal cancer</subject><subject>Larynx</subject><subject>Life Sciences</subject><subject>Metal workers</subject><subject>Occupational exposure</subject><subject>Occupational health</subject><subject>Occupations</subject><subject>Oral cancer</subject><subject>Oral cavity</subject><subject>Oropharynx</subject><subject>Population studies</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk</subject><subject>Santé publique et épidémiologie</subject><subject>Smoking</subject><subject>Spot welding</subject><subject>Stainless steel</subject><subject>Studies</subject><subject>Tobacco</subject><subject>Tobacco smoking</subject><subject>Welding</subject><subject>Working 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and the risk of head and neck cancer: the ICARE study</title><author>Barul, Christine ; Matrat, Mireille ; Auguste, Aviane ; Dugas, Julien ; Radoï, Loredana ; Menvielle, Gwenn ; Févotte, Joëlle ; Guizard, Anne-Valérie ; Stücker, Isabelle ; Luce, Danièle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b443t-74e285dec0ce02435612c879f2cf94b368da385d11d7fb1313d71e39a6684f753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Acids</topic><topic>Alcohol</topic><topic>Arc welding</topic><topic>Asbestos</topic><topic>Cancer</topic><topic>Ecology, environment</topic><topic>Head & neck cancer</topic><topic>Health</topic><topic>Hypopharynx</topic><topic>Interviews</topic><topic>Job titles</topic><topic>Laryngeal cancer</topic><topic>Larynx</topic><topic>Life Sciences</topic><topic>Metal workers</topic><topic>Occupational exposure</topic><topic>Occupational 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group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Welding and the risk of head and neck cancer: the ICARE study</atitle><jtitle>Occupational and environmental medicine (London, England)</jtitle><addtitle>Occup Environ Med</addtitle><date>2020-05-01</date><risdate>2020</risdate><volume>77</volume><issue>5</issue><spage>293</spage><epage>300</epage><pages>293-300</pages><issn>1351-0711</issn><eissn>1470-7926</eissn><abstract>ObjectiveTo investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the Investigation of occupational and environmental CAuses of REspiratory cancers study.MethodsAnalyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95% CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.ResultsWelding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95% CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95% CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend <0.01) and the weighted duration (p-trend <0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95% CI 1.09 to 3.04; OR=2.10, 95% CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer.ConclusionOur findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>31959638</pmid><doi>10.1136/oemed-2019-106080</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-9252-2612</orcidid><orcidid>https://orcid.org/0000-0002-1708-4584</orcidid><orcidid>https://orcid.org/0000-0002-3195-8348</orcidid><orcidid>https://orcid.org/0000-0002-3261-6366</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Occupational and environmental medicine (London, England), 2020-05, Vol.77 (5), p.293-300 |
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| source | JSTOR Archive Collection A-Z Listing |
| subjects | Acids Alcohol Arc welding Asbestos Cancer Ecology, environment Head & neck cancer Health Hypopharynx Interviews Job titles Laryngeal cancer Larynx Life Sciences Metal workers Occupational exposure Occupational health Occupations Oral cancer Oral cavity Oropharynx Population studies Questionnaires Regression analysis Risk Santé publique et épidémiologie Smoking Spot welding Stainless steel Studies Tobacco Tobacco smoking Welding Working hours |
| title | Welding and the risk of head and neck cancer: the ICARE study |
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