Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors

Cinnabarinic acid is an endogenous metabolite of the kynurenine pathway that meets the structural requirements to interact with glutamate receptors. We found that cinnabarinic acid acts as a partial agonist of type 4 metabotropic glutamate (mGlu4) receptors, with no activity at other mGlu receptor s...

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Veröffentlicht in:	Molecular pharmacology 2012-05, Vol.81 (5), p.643-656
Hauptverfasser:	Fazio, F., Lionetto, L., Molinaro, G., Bertrand, H.O., Acher, F., Ngomba, R.T., Notartomaso, S., Curini, M., Rosati, O., Scarselli, P., Di Marco, R., Battaglia, G., Bruno, V., Simmaco, M., Pin, J.P., Nicoletti, F., Goudet, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cells, Cultured Cyclic AMP Cyclic AMP - biosynthesis Glutamic Acid Glutamic Acid - metabolism Humans Kynurenine Kynurenine - metabolism Life Sciences Male Mice Mice, Inbred C57BL Models, Molecular Neurons and Cognition Oxazines Oxazines - analysis Oxazines - pharmacology Rats Rats, Sprague-Dawley Receptors, Metabotropic Glutamate Receptors, Metabotropic Glutamate - agonists Receptors, Metabotropic Glutamate - physiology
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