Two complementary bioassays for screening the estrogenic potency of xenobiotics: recombinant yeast for trout estrogen receptor and trout hepatocyte cultures

A relation between the chemical structure of a xenobiotic and its steroidal action has not yet been clearly established. Thus, it is not possible to define the estrogenic potency of different xenobiotics. An assessment may be accomplished by the use of different bioassays. We have previously develop...

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Veröffentlicht in:	Journal of molecular endocrinology 1997-12, Vol.19 (3), p.321-335
Hauptverfasser:	Petit, F, Le Goff, P, Cravedi, JP, Valotaire, Y, Pakdel, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Biological Assay Cells, Cultured DNA, Recombinant - genetics Drug Evaluation, Preclinical Estrogens, Non-Steroidal - analysis Estrogens, Non-Steroidal - metabolism Estrogens, Non-Steroidal - pharmacology Life Sciences Liver - cytology Liver - metabolism Oncorhynchus mykiss - genetics Protein Binding Receptors, Estrogen - drug effects Receptors, Estrogen - genetics Receptors, Estrogen - metabolism Recombinant Proteins - drug effects Recombinant Proteins - genetics Recombinant Proteins - metabolism RNA, Messenger - drug effects RNA, Messenger - genetics Transcription, Genetic - drug effects Transcription, Genetic - genetics Vitellogenins - drug effects Vitellogenins - genetics Xenobiotics - chemistry Xenobiotics - metabolism Xenobiotics - pharmacology Yeasts - drug effects Yeasts - genetics
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