Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice
Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis...
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| Veröffentlicht in: | Behavior genetics 2020, Vol.50 (1), p.26-40 |
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| creator | Roubertoux, Pierre L. Tordjman, Sylvie Caubit, Xavier di Cristopharo, Julie Ghata, Adeline Fasano, Laurent Kerkerian-Le Goff, Lydia Gubellini, Paolo Carlier, Michèle |
| description | Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from .68 to .81. The factor analysis resulted in a three- factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. The empirical validation with mice sharing a haplo-insufficiency of the zinc-finger transcription factor TSHZ3/Tshz3 associated with ASD shows the discriminant power of the highly loaded items. |
| doi_str_mv | 10.1007/s10519-019-09970-x |
| format | Article |
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Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from .68 to .81. The factor analysis resulted in a three- factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. The empirical validation with mice sharing a haplo-insufficiency of the zinc-finger transcription factor TSHZ3/Tshz3 associated with ASD shows the discriminant power of the highly loaded items.</description><identifier>ISSN: 0001-8244</identifier><identifier>EISSN: 1573-3297</identifier><identifier>DOI: 10.1007/s10519-019-09970-x</identifier><identifier>PMID: 31542842</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Autism ; Behavioral Science and Psychology ; Clinical Psychology ; Construct validity ; Factor analysis ; Genotypes ; Health Psychology ; Life Sciences ; Original Research ; Power ; Psychology ; Public Health ; Reliability ; Social behavior ; Stereotyped behavior ; Validation studies ; Validity ; Zinc ; Zinc finger proteins</subject><ispartof>Behavior genetics, 2020, Vol.50 (1), p.26-40</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>Behavior Genetics is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-253de2d52717482462d31c46f876487bbd2ab2ccb1663f21f269eaf6d2a70b123</citedby><cites>FETCH-LOGICAL-c453t-253de2d52717482462d31c46f876487bbd2ab2ccb1663f21f269eaf6d2a70b123</cites><orcidid>0000-0002-4668-9136 ; 0000-0002-7951-3479 ; 0000-0001-9013-2725</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10519-019-09970-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10519-019-09970-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,777,781,882,12827,27905,27906,30980,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31542842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://amu.hal.science/hal-02440792$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Roubertoux, Pierre L.</creatorcontrib><creatorcontrib>Tordjman, Sylvie</creatorcontrib><creatorcontrib>Caubit, Xavier</creatorcontrib><creatorcontrib>di Cristopharo, Julie</creatorcontrib><creatorcontrib>Ghata, Adeline</creatorcontrib><creatorcontrib>Fasano, Laurent</creatorcontrib><creatorcontrib>Kerkerian-Le Goff, Lydia</creatorcontrib><creatorcontrib>Gubellini, Paolo</creatorcontrib><creatorcontrib>Carlier, Michèle</creatorcontrib><title>Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice</title><title>Behavior genetics</title><addtitle>Behav Genet</addtitle><addtitle>Behav Genet</addtitle><description>Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from .68 to .81. The factor analysis resulted in a three- factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. The empirical validation with mice sharing a haplo-insufficiency of the zinc-finger transcription factor TSHZ3/Tshz3 associated with ASD shows the discriminant power of the highly loaded items.</description><subject>Animals</subject><subject>Autism</subject><subject>Behavioral Science and Psychology</subject><subject>Clinical Psychology</subject><subject>Construct validity</subject><subject>Factor analysis</subject><subject>Genotypes</subject><subject>Health Psychology</subject><subject>Life Sciences</subject><subject>Original Research</subject><subject>Power</subject><subject>Psychology</subject><subject>Public Health</subject><subject>Reliability</subject><subject>Social behavior</subject><subject>Stereotyped behavior</subject><subject>Validation studies</subject><subject>Validity</subject><subject>Zinc</subject><subject>Zinc finger 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Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice</title><author>Roubertoux, Pierre L. ; Tordjman, Sylvie ; Caubit, Xavier ; di Cristopharo, Julie ; Ghata, Adeline ; Fasano, Laurent ; Kerkerian-Le Goff, Lydia ; Gubellini, Paolo ; Carlier, Michèle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-253de2d52717482462d31c46f876487bbd2ab2ccb1663f21f269eaf6d2a70b123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Animals</topic><topic>Autism</topic><topic>Behavioral Science and Psychology</topic><topic>Clinical Psychology</topic><topic>Construct validity</topic><topic>Factor analysis</topic><topic>Genotypes</topic><topic>Health Psychology</topic><topic>Life Sciences</topic><topic>Original Research</topic><topic>Power</topic><topic>Psychology</topic><topic>Public Health</topic><topic>Reliability</topic><topic>Social 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Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roubertoux, Pierre L.</au><au>Tordjman, Sylvie</au><au>Caubit, Xavier</au><au>di Cristopharo, Julie</au><au>Ghata, Adeline</au><au>Fasano, Laurent</au><au>Kerkerian-Le Goff, Lydia</au><au>Gubellini, Paolo</au><au>Carlier, Michèle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice</atitle><jtitle>Behavior genetics</jtitle><stitle>Behav Genet</stitle><addtitle>Behav Genet</addtitle><date>2020</date><risdate>2020</risdate><volume>50</volume><issue>1</issue><spage>26</spage><epage>40</epage><pages>26-40</pages><issn>0001-8244</issn><eissn>1573-3297</eissn><abstract>Modeling in other organism species is one of the crucial stages in ascertaining the association between gene and psychiatric disorder. Testing Autism Spectrum Disorder (ASD) in mice is very popular but construct validity of the batteries is not available. We presented here the first factor analysis of a behavioral model of ASD-like in mice coupled with empirical validation. We defined fourteen measures aligning mouse-behavior measures with the criteria defined by DSM-5 for the diagnostic of ASD. Sixty-five mice belonging to a heterogeneous pool of genotypes were tested. Reliability coefficients vary from .68 to .81. The factor analysis resulted in a three- factor solution in line with DSM criteria: social behavior, stereotypy and narrowness of the field of interest. 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| subjects | Animals Autism Behavioral Science and Psychology Clinical Psychology Construct validity Factor analysis Genotypes Health Psychology Life Sciences Original Research Power Psychology Public Health Reliability Social behavior Stereotyped behavior Validation studies Validity Zinc Zinc finger proteins |
| title | Construct Validity and Cross Validity of a Test Battery Modeling Autism Spectrum Disorder (ASD) in Mice |
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