Two-Dimensional Liquid Chromatography Coupled to High-Resolution Mass Spectrometry for the Analysis of ADCs

From a structural point of view, the complete characterization of ADCs is a challenging task due to their high complexity. ADCs combine the heterogeneity of the initial antibody to the variability associated with the conjugation strategy, the manufacturing process, and the storage. Given the inheren...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Antibody-Drug Conjugates 2020-01, Vol.2078, p.163-185
Hauptverfasser:	Chapel, Soraya, Rouvière, Florent, Sarrut, Morgan, Heinisch, Sabine
Format:	Artikel
Sprache:	eng
Schlagworte:	ADC Amino Acids - chemistry Analytical chemistry Antibodies, Monoclonal - chemistry Antibody–drug conjugate Chemical Sciences Chromatography, High Pressure Liquid Chromatography, Liquid - methods Cysteine-linked ADC High-resolution mass spectrometry Hydrophobic and Hydrophilic Interactions Immunoconjugates - analysis Immunoconjugates - chemistry Immunoconjugates - isolation & purification Intact protein analysis Ion mobility LC × LC Lysine-linked ADC Mass Spectrometry - methods Online two-dimensional liquid chromatography Peptide mapping
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!