A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated With High‐Dose Methotrexate: Data From the OS2006/Sarcoma‐09 Trial

Growing evidence suggests that polymorphisms of genes coding for transporters or enzymes may partially explain the large between subject variability reported for methotrexate (MTX) pharmacokinetics (PK). This prospective study aimed to develop a population PK‐pharmacogenetic model to evaluate the pa...

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Veröffentlicht in:	Journal of clinical pharmacology 2018-12, Vol.58 (12), p.1541-1549
Hauptverfasser:	Lui, Gabrielle, Treluyer, Jean‐Marc, Fresneau, Brice, Piperno‐Neumann, Sophie, Gaspar, Nathalie, Corradini, Nadège, Gentet, Jean‐Claude, Marec Berard, Perrine, Laurence, Valérie, Schneider, Pascale, Entz‐Werle, Natacha, Pacquement, Hélène, Millot, Frédéric, Taque, Sophie, Freycon, Claire, Lervat, Cyril, Deley, Marie Cécile, Mahier Ait Oukhatar, Céline, Brugieres, Laurence, Teuff, Gwénaël, Bouazza, Naïm
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCG2 gene Body weight Bone cancer Data processing Gene polymorphism Immunology Immunomodulators Life Sciences Likelihood ratio Methotrexate Osteosarcoma pharmacogenetics Pharmacokinetics population pharmacokinetics Sarcoma Single-nucleotide polymorphism Surface area Variability
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