The Long Noncoding RNA DNM3OS Is a Reservoir of FibromiRs with Major Functions in Lung Fibroblast Response to TGF-β and Pulmonary Fibrosis

Given the paucity of effective treatments for idiopathic pulmonary fibrosis (IPF), new insights into the deleterious mechanisms controlling lung fibroblast activation, the key cell type driving the fibrogenic process, are essential to develop new therapeutic strategies. TGF-β (transforming growth fa...

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Veröffentlicht in:	American journal of respiratory and critical care medicine 2019-07, Vol.200 (2), p.184-198
Hauptverfasser:	Savary, Grégoire, Dewaeles, Edmone, Diazzi, Serena, Buscot, Matthieu, Nottet, Nicolas, Fassy, Julien, Courcot, Elisabeth, Henaoui, Imène-Sarah, Lemaire, Julie, Martis, Nihal, Van der Hauwaert, Cynthia, Pons, Nicolas, Magnone, Virginie, Leroy, Sylvie, Hofman, Véronique, Plantier, Laurent, Lebrigand, Kevin, Paquet, Agnès, Lino Cardenas, Christian L, Vassaux, Georges, Hofman, Paul, Günther, Andreas, Crestani, Bruno, Wallaert, Benoit, Rezzonico, Roger, Brousseau, Thierry, Glowacki, François, Bellusci, Saverio, Perrais, Michael, Broly, Franck, Barbry, Pascal, Marquette, Charles-Hugo, Cauffiez, Christelle, Mari, Bernard, Pottier, Nicolas
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caveolin 1 - metabolism Disease Drugs Experiments Fibroblasts Fibroblasts - metabolism Gene expression Genomes Growth factors Idiopathic Pulmonary Fibrosis - genetics Idiopathic Pulmonary Fibrosis - metabolism Life Sciences Mice MicroRNAs MicroRNAs - metabolism Myofibroblasts - metabolism Pulmonary fibrosis RNA, Long Noncoding - genetics Signal Transduction Smad Proteins - metabolism Statistical analysis Transforming Growth Factor beta - metabolism Wnt Signaling Pathway
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