Possible role of CYP2B6 genetic polymorphisms in ifosfamide‐induced encephalopathy: report of three cases

Ifosfamide (IFA) is a potent alkylating antitumoral agent, but its use is limited by neurological side effects. IFA is a racemic mixture of two enantiomeric forms, R‐IFA and S‐IFA with a stereoselective metabolism by CYP3A4 and CYP2B6, leading either to bioactive or to toxic pathways. In three conse...

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Veröffentlicht in:	Fundamental & clinical pharmacology 2018-06, Vol.32 (3), p.337-342
Hauptverfasser:	Duflot, Thomas, Marie‐Cardine, Aude, Verstuyft, Céline, Filhon, Bruno, Pereira, Tony, Massy‐Guillemant, Nathalie, Joannidès, Robinson, Bellien, Jérémy, Lamoureux, Fabien
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Anticancer properties Biocompatibility CYP2B6 Encephalopathy Genotyping Ifosfamide ifosfamide metabolism Immunology Life Sciences Metabolism Metabolites methylene blue Neurotoxicity Patients pharmacogenetics Pharmacology Side effects
Online-Zugang:	Volltext
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