Methylerythritol Phosphate Pathway: Enzymatic Evidence for a Rotation in the LytB/IspH‐Catalyzed Reaction

IspH/LytB, an oxygen‐sensitive [4Fe‐4S] enzyme, catalyzes the last step of the methylerythritol phosphate (MEP) pathway, a target for the development of new antimicrobial agents. This metalloenzyme converts (E)‐4‐hydroxy‐3‐methylbut‐2‐en‐1‐yl diphosphate (HMBPP) into the two isoprenoid precursors: i...

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Veröffentlicht in:	Chemistry : a European journal 2020-01, Vol.26 (5), p.1032-1036
Hauptverfasser:	Chaignon, Philippe, Petit, Benoît Eric, Vincent, Bruno, Allouche, Lionel, Seemann, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	[4Fe-4S] cluster Antimicrobial agents Biocatalysis Catalysis Chemical Sciences Chemistry E coli enzyme catalysis Escherichia coli - enzymology Escherichia coli Proteins - metabolism Isopentenyl diphosphate IspH/LytB Life Sciences metalloenzymes methylerythritol phosphate pathway NMR Nuclear magnetic resonance Organic chemistry Organophosphates - chemistry Organophosphates - metabolism Oxidation-Reduction Oxidoreductases - metabolism Phosphates - chemistry Phosphates - metabolism Rotation Substrate Specificity Substrates Terpenes - chemistry Terpenes - metabolism
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