N,N-bis-heteroaryl methylamines: Potent anti-mitotic and highly cytotoxic agents

The synthesis and evaluation of a series of N,N-bis-heterocyclic-methylamines 1 as isoazaerianin analogues are described. It was demonstrated that the replacement of the 3,4,5-trimethoxyphenyl A-ring present in CA-4, isoCA-4 and isoazaerianin by a quinoline or a quinazoline ring is possible and ofte...

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Veröffentlicht in:	European journal of medicinal chemistry 2019-04, Vol.168, p.176-188
Hauptverfasser:	Khelifi, Ilhem, Naret, Timothée, Hamze, Abdallah, Bignon, Jérome, Levaique, Hélène, Garcia Alvarez, Maria Concepcion, Dubois, Joëlle, Provot, Olivier, Alami, Mouad
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Carbazole Chemical Sciences Cytotoxicity Indole isoCA-4 Medicinal Chemistry Organic chemistry Quinazoline Quinoline Tubulin
Online-Zugang:	Volltext
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