Adverse effects of perinatal nicotine exposure on reproductive outcomes
Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using thes...
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| Veröffentlicht in: | Reproduction (Cambridge, England) England), 2015-12, Vol.150 (6), p.R185-R193 |
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| container_title | Reproduction (Cambridge, England) |
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| creator | Wong, Michael K Barra, Nicole G Alfaidy, Nadia Hardy, Daniel B Holloway, Alison C |
| description | Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotine in utero and influence informed clinical guidelines for pregnant women. |
| doi_str_mv | 10.1530/REP-15-0295 |
| format | Article |
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Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotine in utero and influence informed clinical guidelines for pregnant women.</description><identifier>ISSN: 1470-1626</identifier><identifier>EISSN: 1741-7899</identifier><identifier>DOI: 10.1530/REP-15-0295</identifier><identifier>PMID: 26432348</identifier><language>eng</language><publisher>England: Bioscientifica Ltd</publisher><subject>Animals ; Electronic Nicotine Delivery Systems - adverse effects ; Endoplasmic Reticulum Stress - drug effects ; Female ; Fetus - drug effects ; Fetus - metabolism ; Fetus - pathology ; Humans ; Inflammation Mediators - metabolism ; Journal-based learning ; Life Sciences ; Maternal Behavior ; Nicotine - adverse effects ; Nicotinic Agonists - adverse effects ; Oxidative Stress - drug effects ; Pregnancy ; Pregnancy Complications - chemically induced ; Pregnancy Complications - metabolism ; Pregnancy Complications - pathology ; Prenatal Exposure Delayed Effects ; Reproductive Biology ; Review ; Risk Assessment ; Risk Factors ; Smoking - adverse effects ; Smoking - psychology ; Smoking Prevention ; Tobacco Use Cessation Products - adverse effects ; Unfolded Protein Response - drug effects</subject><ispartof>Reproduction (Cambridge, England), 2015-12, Vol.150 (6), p.R185-R193</ispartof><rights>2015 Society for Reproduction and Fertility</rights><rights>2015 Society for Reproduction and Fertility.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b444t-3736c0af4ef262c2cc43be3e1005111e1b1c4e11f9d75225d65be3c318f833db3</citedby><cites>FETCH-LOGICAL-b444t-3736c0af4ef262c2cc43be3e1005111e1b1c4e11f9d75225d65be3c318f833db3</cites><orcidid>0000-0002-0718-2447 ; 0000-0003-2804-5086</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26432348$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02385043$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Michael K</creatorcontrib><creatorcontrib>Barra, Nicole G</creatorcontrib><creatorcontrib>Alfaidy, Nadia</creatorcontrib><creatorcontrib>Hardy, Daniel B</creatorcontrib><creatorcontrib>Holloway, Alison C</creatorcontrib><title>Adverse effects of perinatal nicotine exposure on reproductive outcomes</title><title>Reproduction (Cambridge, England)</title><addtitle>Reproduction</addtitle><description>Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotine in utero and influence informed clinical guidelines for pregnant women.</description><subject>Animals</subject><subject>Electronic Nicotine Delivery Systems - adverse effects</subject><subject>Endoplasmic Reticulum Stress - drug effects</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Fetus - metabolism</subject><subject>Fetus - pathology</subject><subject>Humans</subject><subject>Inflammation Mediators - metabolism</subject><subject>Journal-based learning</subject><subject>Life Sciences</subject><subject>Maternal Behavior</subject><subject>Nicotine - adverse effects</subject><subject>Nicotinic Agonists - adverse effects</subject><subject>Oxidative Stress - drug effects</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - chemically induced</subject><subject>Pregnancy Complications - metabolism</subject><subject>Pregnancy Complications - pathology</subject><subject>Prenatal Exposure Delayed Effects</subject><subject>Reproductive Biology</subject><subject>Review</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking - psychology</subject><subject>Smoking Prevention</subject><subject>Tobacco Use Cessation Products - adverse effects</subject><subject>Unfolded Protein Response - drug effects</subject><issn>1470-1626</issn><issn>1741-7899</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LAzEQxYMo1q-Td9mjIquZfOzHsRRthYIieg7Z7AQj201Ndov-96ZUPXqaN_N-PIZHyDnQG5Cc3j7fPeUgc8pquUeOoBSQl1Vd7yctSppDwYoJOY7xnVKQVVkckgkrBGdcVEdkPm03GCJmaC2aIWbeZmsMrteD7rLeGT-4Prmfax_HgJnvs4Dr4NvRDG6T9nEwfoXxlBxY3UU8-5kn5PX-7mW2yJeP84fZdJk3Qogh5yUvDNVWoGUFM8wYwRvkCJRKAEBowAgEsHVbSsZkW8hkGw6VrThvG35Crna5b7pT6-BWOnwpr51aTJdqe6OMV5IKvoHEXu7Y9O_HiHFQKxcNdp3u0Y9RQckpZaJmdUKvd6gJPsaA9i8bqNq2rFLLSahty4m--AkemxW2f-xvrQmAHdA4H43DfnDWGf1v6Dd5Z4bw</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Wong, Michael K</creator><creator>Barra, Nicole G</creator><creator>Alfaidy, Nadia</creator><creator>Hardy, Daniel B</creator><creator>Holloway, Alison C</creator><general>Bioscientifica Ltd</general><general>BioScientifica [2001-....]</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-0718-2447</orcidid><orcidid>https://orcid.org/0000-0003-2804-5086</orcidid></search><sort><creationdate>201512</creationdate><title>Adverse effects of perinatal nicotine exposure on reproductive outcomes</title><author>Wong, Michael K ; Barra, Nicole G ; Alfaidy, Nadia ; Hardy, Daniel B ; Holloway, Alison C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b444t-3736c0af4ef262c2cc43be3e1005111e1b1c4e11f9d75225d65be3c318f833db3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Electronic Nicotine Delivery Systems - adverse effects</topic><topic>Endoplasmic Reticulum Stress - drug effects</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>Fetus - metabolism</topic><topic>Fetus - pathology</topic><topic>Humans</topic><topic>Inflammation Mediators - metabolism</topic><topic>Journal-based learning</topic><topic>Life Sciences</topic><topic>Maternal Behavior</topic><topic>Nicotine - adverse effects</topic><topic>Nicotinic Agonists - adverse effects</topic><topic>Oxidative Stress - drug effects</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - chemically induced</topic><topic>Pregnancy Complications - metabolism</topic><topic>Pregnancy Complications - pathology</topic><topic>Prenatal Exposure Delayed Effects</topic><topic>Reproductive Biology</topic><topic>Review</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><topic>Smoking - adverse effects</topic><topic>Smoking - psychology</topic><topic>Smoking Prevention</topic><topic>Tobacco Use Cessation Products - adverse effects</topic><topic>Unfolded Protein Response - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Michael K</creatorcontrib><creatorcontrib>Barra, Nicole G</creatorcontrib><creatorcontrib>Alfaidy, Nadia</creatorcontrib><creatorcontrib>Hardy, Daniel B</creatorcontrib><creatorcontrib>Holloway, Alison C</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Reproduction (Cambridge, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Michael K</au><au>Barra, Nicole G</au><au>Alfaidy, Nadia</au><au>Hardy, Daniel B</au><au>Holloway, Alison C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse effects of perinatal nicotine exposure on reproductive outcomes</atitle><jtitle>Reproduction (Cambridge, England)</jtitle><addtitle>Reproduction</addtitle><date>2015-12</date><risdate>2015</risdate><volume>150</volume><issue>6</issue><spage>R185</spage><epage>R193</epage><pages>R185-R193</pages><issn>1470-1626</issn><eissn>1741-7899</eissn><abstract>Nicotine exposure during pregnancy through cigarette smoking, nicotine replacement therapies or e-cigarette use continues to be a widespread public health problem, impacting both fetal and postnatal health. Yet, at this time, there remains limited data regarding the safety and efficacy in using these nicotine products during pregnancy. Notably, reports assessing the effect of nicotine exposure on postnatal health outcomes in humans, including reproductive health, are severely lacking. Our current understanding regarding the consequences of nicotine exposure during pregnancy is limited to a few animal studies, which do not comprehensively address the underlying cellular mechanisms involved. This paper aims to critically review the current knowledge from human and animal studies regarding the direct and indirect effects (e.g. obesity) of maternal nicotine exposure, regardless of its source, on reproductive outcomes in pregnancy and postnatal life. Furthermore, this review highlights several key cellular mechanisms involved in these adverse reproductive deficits including oxidative stress, inflammation, and endoplasmic reticulum (ER) stress. By understanding the interplay of the cellular mechanisms involved, further strategies could be developed to prevent the reproductive abnormalities resulting from exposure to nicotine in utero and influence informed clinical guidelines for pregnant women.</abstract><cop>England</cop><pub>Bioscientifica Ltd</pub><pmid>26432348</pmid><doi>10.1530/REP-15-0295</doi><orcidid>https://orcid.org/0000-0002-0718-2447</orcidid><orcidid>https://orcid.org/0000-0003-2804-5086</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Electronic Nicotine Delivery Systems - adverse effects Endoplasmic Reticulum Stress - drug effects Female Fetus - drug effects Fetus - metabolism Fetus - pathology Humans Inflammation Mediators - metabolism Journal-based learning Life Sciences Maternal Behavior Nicotine - adverse effects Nicotinic Agonists - adverse effects Oxidative Stress - drug effects Pregnancy Pregnancy Complications - chemically induced Pregnancy Complications - metabolism Pregnancy Complications - pathology Prenatal Exposure Delayed Effects Reproductive Biology Review Risk Assessment Risk Factors Smoking - adverse effects Smoking - psychology Smoking Prevention Tobacco Use Cessation Products - adverse effects Unfolded Protein Response - drug effects |
| title | Adverse effects of perinatal nicotine exposure on reproductive outcomes |
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