Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β

In this study, the authors show that neuronal activity, induced by natural exploration, exposure to visual stimuli or optogenetic probe–mediated stimulation, can induce double-stranded DNA breaks (DSBs) in neurons. The numbers of these DSBs were aggravated in the presence of amyloid precursor protei...

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Veröffentlicht in:	Nature neuroscience 2013-05, Vol.16 (5), p.613-621
Hauptverfasser:	Suberbielle, Elsa, Sanchez, Pascal E, Kravitz, Alexxai V, Wang, Xin, Ho, Kaitlyn, Eilertson, Kirsten, Devidze, Nino, Kreitzer, Anatol C, Mucke, Lennart
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1427/2122 631/378/1595/1554 631/378/1689/1283 631/378/1697 631/378/2571/1696 631/378/2584/2585 631/378/340 Amyloid beta-Peptides - metabolism Amyloid beta-protein Amyloid beta-Protein Precursor - genetics Animal Genetics and Genomics Animals Animals, Newborn Behavioral Sciences Biological Techniques Biomedicine Cells, Cultured Cerebral Cortex - cytology Cerebral Cortex - drug effects Channelrhodopsins Cognitive science Cognitive Sciences Corpus Striatum - drug effects Corpus Striatum - metabolism Corticosterone - blood Disease Models, Animal DNA Breaks, Double-Stranded DNA damage Excitatory Amino Acid Antagonists - pharmacology Exploratory Behavior - drug effects Exploratory Behavior - physiology Gene Expression Regulation - drug effects Genetic aspects Health aspects Hippocampus - cytology Hippocampus - drug effects Histones - metabolism Human health and pathology Humans Life Sciences Mice Mice, Inbred C57BL Mice, Transgenic Neural circuitry Neurobiology Neurons Neurons - drug effects Neurons - physiology Neurons and Cognition Neuroscience Neurosciences Photic Stimulation Physiological aspects Psychiatrics and mental health Quinoxalines - pharmacology Reactive Oxygen Species - metabolism Stress, Physiological - physiology tau Proteins - genetics Valine - analogs & derivatives Valine - pharmacology
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