Adrenocorticotropin/3′,5′-Cyclic AMP-Mediated Transcription of the Scavenger akr1-b7 Gene in Adrenocortical Cells Is Dependent on Three Functionally Distinct Steroidogenic Factor-1-Responsive Elements

The akr1-b7 gene encodes a scavenger enzyme expressed in steroidogenic glands under pituitary control. In the zona fasciculata of the adrenal cortex where its expression is controlled by ACTH, AKR1-B7 detoxifies isocaproaldehyde produced during the first step of steroidogenesis. Three steroidogenic...

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Veröffentlicht in:	Endocrinology (Philadelphia) 2004-02, Vol.145 (2), p.508-518
Hauptverfasser:	Val, Pierre, Aigueperse, Christelle, Ragazzon, Bruno, Veyssière, Georges, Lefrançois-Martinez, Anne-Marie, Martinez, Antoine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal cortex Adrenal Cortex - metabolism Adrenocorticotropic hormone Adrenocorticotropic Hormone - physiology Adrenocorticotropin (ACTH) Aldehyde Reductase Animals Base Sequence Binding Binding Sites - genetics Cell Line Cell Nucleus - chemistry Colforsin - pharmacology Cyclic AMP Cyclic AMP - physiology DNA - chemistry DNA - metabolism DNA-Binding Proteins - metabolism Fushi Tarazu Transcription Factors Gene expression Gene sequencing HeLa Cells Homeodomain Proteins Humans Leydig cells Life Sciences Mice Mutagenesis Pituitary Promoter Regions, Genetic - genetics Proteins - genetics Receptors, Cytoplasmic and Nuclear Response Elements - genetics Steroidogenesis Steroidogenic Factor 1 Transcription Factors - metabolism Transcription, Genetic Transcriptional Activation Transfection Transgenic mice
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