PDK1 decreases TACE-mediated α-secretase activity and promotes disease progression in prion and Alzheimer's diseases

α-secretase–mediated processing of cellular prion protein and amyloid precursor protein is decreased in prion and Alzheimer's diseases. Mathéa Pietri et al . now show that activity of a kinase, PDK1, is increased in the brain following prion infection and with amyloid pathology. This results in...

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Veröffentlicht in:	Nature Medicine 2013-09, Vol.19 (9), p.1124-1131
Hauptverfasser:	Pietri, Mathéa, Dakowski, Caroline, Hannaoui, Samia, Alleaume-Butaux, Aurélie, Hernandez-Rapp, Julia, Ragagnin, Audrey, Mouillet-Richard, Sophie, Haik, Stéphane, Bailly, Yannick, Peyrin, Jean-Michel, Launay, Jean-Marie, Kellermann, Odile, Schneider, Benoit
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/1689/1283 631/80/304 631/80/86 692/308/575 ADAM Proteins - metabolism ADAM17 Protein Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Biochemistry Biochemistry, Molecular Biology Biomedicine Brain - metabolism Brain - pathology Cancer Research Caveolin 1 - metabolism Cell Survival Cells, Cultured Development and progression Disease Progression Health aspects Humans Infectious Diseases Life Sciences Metabolic Diseases Mice Mice, Inbred C57BL Mice, Transgenic Molecular Medicine Neurons and Cognition Neurosciences Phosphorylation Phosphotransferases Prion Diseases - metabolism Prions Prions - metabolism Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism Receptors, Tumor Necrosis Factor, Type I - metabolism RNA Interference RNA, Small Interfering Tumor necrosis factor Tumor Necrosis Factor-alpha - metabolism
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