N,O-Dialkyl deoxynojirimycin derivatives as CERT START domain ligands

[Display omitted] Dysregulation of the ceramide transport protein CERT is associated to diseases such as cancer. In search for new CERT START domain ligands, N-dodecyl-deoxynojirimycin (N-dodecyl-DNJ) iminosugar was found to display, as a ceramide mimic, significant protein recognition. To reinforce...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2020-01, Vol.30 (2), p.126796-126796, Article 126796
Hauptverfasser:	Castellan, Tessa, Santos, Cécile, Rodriguez, Frédéric, Lepage, Mathieu L., Liang, Yan, Bodlenner, Anne, Compain, Philippe, Génisson, Yves, Dehoux, Cécile, Ballereau, Stéphanie
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Deoxynojirimycin - chemistry 1-Deoxynojirimycin - metabolism Binding Sites Ceramide Ceramides - metabolism CERT Chemical Sciences Deoxynojirimycin Glucosamine - analogs & derivatives Glucosamine - chemistry Glucosamine - metabolism Glycoside Hydrolases - antagonists & inhibitors Glycoside Hydrolases - metabolism Humans Iminosugar Ligands Molecular Docking Simulation Protein Binding Protein Domains Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - metabolism Sphingolipid Stereoisomerism Thermodynamics
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