Overall Structures of Mycobacterium tuberculosis DNA Gyrase Reveal the Role of a Corynebacteriales GyrB-Specific Insert in ATPase Activity

Despite sharing common features, previous studies have shown that gyrases from different species have been modified throughout evolution to modulate their properties. Here, we report two crystal structures of Mycobacterium tuberculosis DNA gyrase, an apo and AMPPNP-bound form at 2.6-Å and 3.3-Å reso...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Structure (London) 2019-04, Vol.27 (4), p.579-589.e5
Hauptverfasser:	Petrella, Stéphanie, Capton, Estelle, Raynal, Bertrand, Giffard, Clément, Thureau, Aurélien, Bonneté, Françoise, Alzari, Pedro M., Aubry, Alexandra, Mayer, Claudine
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases - chemistry Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Adenosine Triphosphate - chemistry Adenosine Triphosphate - metabolism Adenylyl Imidodiphosphate - chemistry Adenylyl Imidodiphosphate - metabolism Amino Acid Sequence Apoproteins - chemistry Apoproteins - genetics Apoproteins - metabolism ATPase activity Binding Sites Chemical Physics Cloning, Molecular Corynebacteriales Corynebacterium - chemistry Corynebacterium - enzymology Crystallography, X-Ray DNA - chemistry DNA - metabolism DNA gyrase DNA Gyrase - chemistry DNA Gyrase - genetics DNA Gyrase - metabolism DNA-binding protein Escherichia coli - genetics Escherichia coli - metabolism fluoroquinolone Gene Expression Genetic Vectors - chemistry Genetic Vectors - metabolism Kinetics Models, Molecular molecular machine Mycobacterium tuberculosis Mycobacterium tuberculosis - chemistry Mycobacterium tuberculosis - enzymology Physics Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Protein Structure, Quaternary Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism SAXS experiments Sequence Alignment Sequence Homology, Amino Acid type IIA topoisomerases X-ray structure
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!