The O-β-linked N-acetylglucosaminylation of the Lamin B receptor and its impact on DNA binding and phosphorylation

Lamin B Receptor (LBR) is an integral protein of the interphase inner nuclear membrane that is implicated in chromatin anchorage to the nuclear envelope. Phosphorylation of a stretch of arginine-serine (RS) dipeptides in the amino-terminal nucleoplasmic domain of LBR regulates the interactions of th...

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Veröffentlicht in:	Biochimica et biophysica acta. General subjects 2018-04, Vol.1862 (4), p.825-835
Hauptverfasser:	Smet-Nocca, Caroline, Page, Adeline, Cantrelle, François-Xavier, Nikolakaki, Eleni, Landrieu, Isabelle, Giannakouros, Thomas
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Amino Acid Sequence Animals Binding Sites - genetics Biochemistry, Molecular Biology CDC2 Protein Kinase - genetics CDC2 Protein Kinase - metabolism DNA - genetics DNA - metabolism Glycosylation Humans Lamin B Receptor Life Sciences Mass spectrometry N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism NMR spectroscopy O-β-linked N-acetyl-glucosaminylation (O-GlcNAc) Peptides - genetics Peptides - metabolism Phosphorylation Protein Binding Protein phosphorylation Proto-Oncogene Proteins c-akt - genetics Proto-Oncogene Proteins c-akt - metabolism Rats Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism RS domain Sequence Homology, Amino Acid Turkeys
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