Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2

Prostate cancer (PCa) is one of the major public health problems in Western countries. Recently, the TMPRSS2:ERG gene fusion, which results in the aberrant expression of the transcription factor ERG, has been shown to be the most common gene rearrangement in PCa. Previous studies have determined the...

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Veröffentlicht in:	Oncogene 2014-04, Vol.33 (17), p.2204-2214
Hauptverfasser:	Tian, T V, Tomavo, N, Huot, L, Flourens, A, Bonnelye, E, Flajollet, S, Hot, D, Leroy, X, de Launoit, Y, Duterque-Coquillaud, M
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67/68 692/420/755 692/699/67/322 692/699/67/589/466 Androgen receptors Apoptosis Biochemistry, Molecular Biology Cancer Cell adhesion & migration Cell Biology Cell fusion Cell Line, Tumor Cell migration Cell Movement Cell Proliferation DNA microarrays Ectopic expression ERG gene Gelatinase B Gene Expression Regulation Gene fusion Gene rearrangement Genetic aspects Genomics Human Genetics Human health and pathology Humans Identification and classification Internal Medicine Invasiveness Life Sciences Lymphatic Metastasis Male Matrix Metalloproteinase 9 - metabolism Medicine Medicine & Public Health Metalloproteinase Metastases Metastasis Nerve Tissue Proteins - metabolism Oncogene Proteins, Fusion - genetics Oncogene Proteins, Fusion - metabolism Oncogenes Oncology Oncology, Experimental original-article Phenotype Phenotypes Prostate cancer Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Public health Receptors, Cell Surface - metabolism Transcriptome Tumors Urology and Nephrology
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