HLA Class I Antibodies Provoke Graft Arteriosclerosis in Human Arteries Transplanted into SCID/Beige Mice

Antibodies toward HLA class I and/or MICA are commonly observed in transplanted patients suffering from allograft arteriosclerosis, also called chronic vascular rejection (CVR). The relative importance of cellular versus humoral alloreactivity for CVR is still disputed. We demonstrate that antibodie...

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Veröffentlicht in:	American journal of transplantation 2009-11, Vol.9 (11), p.2607-2614
Hauptverfasser:	Galvani, S., Augé, N., Calise, D., Thiers, J. C., Canivet, C., Kamar, N., Rostaing, L., Abbal, M., Sallusto, F., Salvayre, R., Böhler, T., Zou, Y., Stastny, P., Nègre‐Salvayre, A., Thomsen, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allograft arteriosclerosis animal models Animals Antibodies, Heterophile - blood Antibodies, Heterophile - immunology antibody‐mediated rejection anti‐HLA antibodies Arteriosclerosis - immunology Arteriosclerosis - pathology Atherosclerosis (general aspects, experimental research) Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cell Division - immunology chronic allograft rejection Graft Rejection - immunology Graft Rejection - pathology Histocompatibility Antigens Class I - immunology Human health and pathology Humans Life Sciences Medical sciences Mesenteric Arteries - immunology Mesenteric Arteries - pathology Mesenteric Arteries - transplantation Mice Mice, SCID Muscle, Smooth, Vascular - immunology Muscle, Smooth, Vascular - pathology smooth muscle cells Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Transplantation, Heterologous - immunology Tunica Intima - immunology Tunica Intima - pathology
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