N6L pseudopeptide interferes with nucleophosmin protein-protein interactions and sensitizes leukemic cells to chemotherapy

NPM1 is a multifunctional nucleolar protein implicated in several processes such as ribosome maturation and export, DNA damage response and apoptotic response to stress stimuli. The NPM1 gene is involved in human tumorigenesis and is found mutated in one third of acute myeloid leukemia patients, lea...

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Veröffentlicht in:	Cancer letters 2018-01, Vol.412, p.272-282
Hauptverfasser:	De Cola, A., Franceschini, M., Di Matteo, A., Colotti, G., Celani, R., Clemente, E., Ippoliti, R., Cimini, A.M., Dhez, A.C., Vallée, B., Raineri, F., Cascone, I., Destouches, D., De Laurenzi, V., Courty, J., Federici, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myeloid leukemia Antitumor activity Apoptosis Brain cancer Breast cancer Cancer Cell Line, Tumor Cell surface Cells Chemotherapy Cytarabine Cytarabine - pharmacology Deoxyribonucleic acid DNA DNA damage DNA repair Doxorubicin Doxorubicin - pharmacology Humans Leukemia Leukemia, Myeloid, Acute - drug therapy Life Sciences Ligands Localization Mutation Myeloid leukemia NPM1 mutations Nuclear Proteins - analysis Nuclear Proteins - genetics Nuclear Proteins - physiology Nucleoli Nucleolin p53 Protein Peptides - pharmacology Prostate Protein interaction Proteins Targeted therapy Toxicity Treatment resistance Tumor cell lines Tumor Suppressor Protein p53 - physiology Tumorigenesis
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