Diversification of human plasmacytoid predendritic cells in response to a single stimulus

Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine...

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Veröffentlicht in:	Nature immunology 2018-01, Vol.19 (1), p.63-75
Hauptverfasser:	Alculumbre, Solana G., Saint-André, Violaine, Di Domizio, Jeremy, Vargas, Pablo, Sirven, Philemon, Bost, Pierre, Maurin, Mathieu, Maiuri, Paolo, Wery, Maxime, Roman, Mabel San, Savey, Léa, Touzot, Maxime, Terrier, Benjamin, Saadoun, David, Conrad, Curdin, Gilliet, Michel, Morillon, Antonin, Soumelis, Vassili
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - immunology Autocrine signalling B7-1 Antigen - immunology B7-1 Antigen - metabolism B7-H1 Antigen - immunology B7-H1 Antigen - metabolism Biodiversity Biological response modifiers Biomedical and Life Sciences Biomedicine CD80 antigen Cells, Cultured Cytokines - genetics Cytokines - immunology Cytokines - metabolism Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Dendritic Cells - ultrastructure Diversification Division of labor Gene Expression - immunology Gene Expression Profiling - methods Heterogeneity Humans Immunity, Innate - immunology Immunology Infectious Diseases Inflammation Innate immunity Interferon Interferon Type I - genetics Interferon Type I - immunology Interferon Type I - metabolism Life Sciences Lupus Lupus Erythematosus, Systemic - immunology Microscopy, Electron, Transmission Morphology Orthomyxoviridae - immunology Paracrine signalling PD-L1 protein Psoriasis Psoriasis - immunology Ribonucleic acid RNA Skin diseases Specialization Subpopulations Tumor necrosis factor
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