Crystal Structure of OxyB, a Cytochrome P450 Implicated in an Oxidative Phenol Coupling Reaction during Vancomycin Biosynthesis

Gene-inactivation studies point to the involvement of OxyB in catalyzing the first oxidative phenol coupling reaction during glycopeptide antibiotic biosynthesis. TheoxyB gene has been cloned and sequenced from the vancomycin producer Amycolatopsis orientalis, and the hemoprotein has been produced i...

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Veröffentlicht in:	The Journal of biological chemistry 2002-12, Vol.277 (49), p.47476-47485
Hauptverfasser:	Zerbe, Katja, Pylypenko, Olena, Vitali, Francesca, Zhang, Weiwen, Rouset, Severine, Heck, Markus, Vrijbloed, Jan W., Bischoff, Daniel, Bister, Bojan, Süssmuth, Roderich D., Pelzer, Stefan, Wohlleben, Wolfgang, Robinson, John A., Schlichting, Ilme
Format:	Artikel
Sprache:	eng
Schlagworte:	Actinomycetales - metabolism Amino Acid Sequence Asparagine - chemistry Binding Sites Cloning, Molecular Crystallography, X-Ray Electrons Escherichia coli - metabolism Ferredoxin-NADP Reductase - metabolism Ferredoxins - metabolism Gene Library Genetic Vectors Hydrogen-Ion Concentration Life Sciences Models, Chemical Models, Genetic Models, Molecular Molecular Sequence Data Oxygen - metabolism Peptides - chemistry Peptides - metabolism Phenol - metabolism Protein Binding Receptors, Steroid - chemistry Sequence Analysis, DNA Spectrophotometry Ultraviolet Rays Vancomycin - biosynthesis X-Rays
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