Recombinant human IL-15 trans-presentation by B leukemic cells from chronic lymphocytic leukemia induces autologous NK cell proliferation leading to improved anti-CD20 immunotherapy

Recombinant human IL-15 (rhIL-15) is one of the most promising cytokines for antitumor immunotherapy. In physiology IL-15 trans-presentation by accessory cells leads to pleiotropic activities, including activation of immune cells, such as NK cells. NK cells are largely involved in Ab-dependent cellu...

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Veröffentlicht in:	The Journal of immunology (1950) 2013-10, Vol.191 (7), p.3634-3640
Hauptverfasser:	Laprevotte, Emilie, Voisin, Gregory, Ysebaert, Loïc, Klein, Christian, Daugrois, Camille, Laurent, Guy, Fournie, Jean-Jacques, Quillet-Mary, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived - pharmacology Antibodies, Monoclonal, Murine-Derived - therapeutic use Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Cancer Cell Proliferation - drug effects Female Humans Immunology Immunotherapy Interleukin-15 - pharmacology Interleukin-15 - therapeutic use Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy Leukemia, Lymphocytic, Chronic, B-Cell - immunology Life Sciences Lymphocyte Activation - drug effects Lymphocyte Activation - immunology Lymphocyte Depletion Male Middle Aged Receptors, IgG - metabolism Recombinant Proteins - pharmacology Rituximab
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