Vaccine adjuvants CpG (oligodeoxynucleotides ODNs), MPL (3-O-deacylated monophosphoryl lipid A) and naloxone-enhanced Th1 immune response to the Plasmodium vivax recombinant thrombospondin-related adhesive protein (TRAP) in mice

Despite considerable efforts toward vaccine development over decades, there is no available effective vaccine against Plasmodium vivax . Thrombospondin-related adhesive protein of P. vivax (PvTRAP) is essential for sporozoite motility and invasions into mosquito’s salivary gland and vertebrate’s hep...

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Veröffentlicht in:	Medical microbiology and immunology 2018-11, Vol.207 (5-6), p.271-286
Hauptverfasser:	Nazeri, Saeed, Zakeri, Sedigheh, Mehrizi, Akram A., Djadid, Navid D., Snounou, Georges, Andolina, Chiara, Nosten, François
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - administration & dosage Animals Antibodies, Protozoan - blood Avidity Biomedical and Life Sciences Biomedicine CpG islands Female Formulations Immune response Immune response (cell-mediated) Immunogenicity Immunoglobulin G Immunoglobulin G - blood Immunoglobulins Immunology Interferon Interferon-gamma - metabolism Interleukin 10 Interleukin 4 Interleukin-10 - metabolism Interleukin-4 - metabolism Leukocytes, Mononuclear - immunology Life Sciences Lipid A Lipid A - administration & dosage Lipid A - analogs & derivatives Lymphocytes T Malaria Vaccines - administration & dosage Malaria Vaccines - genetics Malaria Vaccines - immunology Medical Microbiology Mice Mice, Inbred C57BL Microbiology and Parasitology Monophosphoryl lipid A Naloxone Naloxone - administration & dosage Oligodeoxyribonucleotides - administration & dosage Oligonucleotides Original Investigation Parasitology Plasmodium vivax Plasmodium vivax - immunology Protozoan Proteins - genetics Protozoan Proteins - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Salivary gland Th1 Cells - immunology Thrombospondin Thrombospondin-related adhesive protein Vaccine development Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vaccinology Virology γ-Interferon
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