Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade
Since the outcomes of patients with candidemia is poor and Candida spp. with increased resistance to antifungal therapy may be associated with these results, the emergence of these blood infections caused by non-C. albicans Candida spp. was explored prospectively over a two-year period (2009-2010)....
Gespeichert in:
| Veröffentlicht in: | Medical mycology (Oxford) 2013-01, Vol.51 (1), p.33-37 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 37 |
|---|---|
| container_issue | 1 |
| container_start_page | 33 |
| container_title | Medical mycology (Oxford) |
| container_volume | 51 |
| creator | Parmeland, Laurence Gazon, Mathieu Guerin, Claude Argaud, Laurent Lehot, Jean-Jacques Bastien, Olivier Allaouchiche, Bernard Michallet, Mauricette Picot, Stephane Bienvenu, Anne-Lise |
| description | Since the outcomes of patients with candidemia is poor and Candida spp. with increased resistance to antifungal therapy may be associated with these results, the emergence of these blood infections caused by non-C. albicans Candida spp. was explored prospectively over a two-year period (2009-2010). Candidemia was defined as the recovery of Candida spp. in culture from a patient's blood sample. The in vitro susceptibility of each isolate to amphotericin B, caspofungin, fluconazole and voriconazole was determined. In addition, characteristics of patients and outcomes were investigated in real-time. The Candida distribution was compared to that observed in a similar study 10 years earlier in the same hospital. A total of 182 patients with candidemia were included in the study. While C. albicans was the most frequently isolated species (n = 102), non-C. albicans Candida spp. included; C. glabrata (n = 32), C. parapsilosis (n = 21), C. tropicalis (n = 13), C. krusei (n = 8), C. kefyr (n = 3), C. lusitaniae (n = 2), C. lipolytica (n = 2), C. famata (n = 1), C. guilliermondii (n = 1), C. inconspicua (n = 1), C. dubliniensis (n = 1), C. sake (n = 1) and C. nivariensis (n = 1). In seven patients, C. albicans was associated with another Candida spp. Surprisingly, this prospective study demonstrated that regardless of the department (intensive care unit or hematological department), Candida spp. distribution was no different from that found in the 1998-2001 survey, except for C. krusei. A reduction in the proportion of C. krusei isolates was observed from 2000-2010 (P = 0.028) as a result of its decreased recovery in the hematological department. |
| doi_str_mv | 10.3109/13693786.2012.686673 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02334577v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.3109/13693786.2012.686673</oup_id><sourcerecordid>1237507855</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-a3073210358c11af9e367740757047877c5f1da01b550e31c31808c7f059bdd23</originalsourceid><addsrcrecordid>eNqNkU9r3DAQxUVpaNK036AUH5uDNyPJ-uNLISxpU1jIpT2LWUnOKtjSVrIL_fbV4iSXQullNKP5vSfQI-QDhQ2n0F9TLnuutNwwoGwjtZSKvyIXtJPQMgX969pXpD0x5-RtKY8AVPWMvyHnjEkNvdIXxGwxuuCwwXEfLMbS1LmJKbZ_LYYlPvgpYBNihWotc5iXOaSIY3NI5Rjm2rglh_jQYOO8ReffkbMBx-LfP52X5MeX2-_bu3Z3__Xb9mbX2o7LuUUOijMKXGhLKQ6951KpDpRQ0CmtlBUDdQh0LwR4Ti2nGrRVA4h-7xzjl-Rq9T3gaI45TJh_m4TB3N3szOkOGOedUOoXreynlT3m9HPxZTZTKNaPI0aflmIo40qA0kJUtFtRm1Mp2Q8v3hTMKQbzHIM5xWDWGKrs49MLy37y7kX0_O8VuF6BtBz_1_LzqghxSHnCg8dxPljM3jymJdcMyr8N_gA4n6Gc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1237507855</pqid></control><display><type>article</type><title>Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade</title><source>MEDLINE</source><source>Oxford University Press Journals All Titles (1996-Current)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Parmeland, Laurence ; Gazon, Mathieu ; Guerin, Claude ; Argaud, Laurent ; Lehot, Jean-Jacques ; Bastien, Olivier ; Allaouchiche, Bernard ; Michallet, Mauricette ; Picot, Stephane ; Bienvenu, Anne-Lise</creator><creatorcontrib>Parmeland, Laurence ; Gazon, Mathieu ; Guerin, Claude ; Argaud, Laurent ; Lehot, Jean-Jacques ; Bastien, Olivier ; Allaouchiche, Bernard ; Michallet, Mauricette ; Picot, Stephane ; Bienvenu, Anne-Lise ; Study Group</creatorcontrib><description>Since the outcomes of patients with candidemia is poor and Candida spp. with increased resistance to antifungal therapy may be associated with these results, the emergence of these blood infections caused by non-C. albicans Candida spp. was explored prospectively over a two-year period (2009-2010). Candidemia was defined as the recovery of Candida spp. in culture from a patient's blood sample. The in vitro susceptibility of each isolate to amphotericin B, caspofungin, fluconazole and voriconazole was determined. In addition, characteristics of patients and outcomes were investigated in real-time. The Candida distribution was compared to that observed in a similar study 10 years earlier in the same hospital. A total of 182 patients with candidemia were included in the study. While C. albicans was the most frequently isolated species (n = 102), non-C. albicans Candida spp. included; C. glabrata (n = 32), C. parapsilosis (n = 21), C. tropicalis (n = 13), C. krusei (n = 8), C. kefyr (n = 3), C. lusitaniae (n = 2), C. lipolytica (n = 2), C. famata (n = 1), C. guilliermondii (n = 1), C. inconspicua (n = 1), C. dubliniensis (n = 1), C. sake (n = 1) and C. nivariensis (n = 1). In seven patients, C. albicans was associated with another Candida spp. Surprisingly, this prospective study demonstrated that regardless of the department (intensive care unit or hematological department), Candida spp. distribution was no different from that found in the 1998-2001 survey, except for C. krusei. A reduction in the proportion of C. krusei isolates was observed from 2000-2010 (P = 0.028) as a result of its decreased recovery in the hematological department.</description><identifier>ISSN: 1369-3786</identifier><identifier>EISSN: 1460-2709</identifier><identifier>EISSN: 1365-280X</identifier><identifier>DOI: 10.3109/13693786.2012.686673</identifier><identifier>PMID: 22680978</identifier><language>eng</language><publisher>UK: Informa Healthcare</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Antifungal Agents - pharmacology ; Bacteriology ; Biodiversity ; Candida - classification ; Candida - drug effects ; Candida - isolation & purification ; Candida albicans - classification ; Candida albicans - drug effects ; Candida albicans - isolation & purification ; Candidemia - diagnosis ; Candidemia - microbiology ; Candidemia - mortality ; Child ; Child, Preschool ; Demography ; Drug Resistance, Fungal ; Ecology, environment ; Ecosystems ; Epidemiological Monitoring ; Female ; Hospitals ; Humans ; Infant ; Life Sciences ; Male ; Microbial Sensitivity Tests ; Microbiology and Parasitology ; Middle Aged ; Populations and Evolution ; Prospective Studies ; Quantitative Methods ; Risk Factors ; Systematics, Phylogenetics and taxonomy ; Young Adult</subject><ispartof>Medical mycology (Oxford), 2013-01, Vol.51 (1), p.33-37</ispartof><rights>2013 ISHAM 2013</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-a3073210358c11af9e367740757047877c5f1da01b550e31c31808c7f059bdd23</citedby><cites>FETCH-LOGICAL-c436t-a3073210358c11af9e367740757047877c5f1da01b550e31c31808c7f059bdd23</cites><orcidid>0000-0003-1962-0464 ; 0000-0002-5735-6759 ; 0000-0002-4953-9125 ; 0000-0003-4700-6672 ; 0000-0003-0988-1716</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22680978$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02334577$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Parmeland, Laurence</creatorcontrib><creatorcontrib>Gazon, Mathieu</creatorcontrib><creatorcontrib>Guerin, Claude</creatorcontrib><creatorcontrib>Argaud, Laurent</creatorcontrib><creatorcontrib>Lehot, Jean-Jacques</creatorcontrib><creatorcontrib>Bastien, Olivier</creatorcontrib><creatorcontrib>Allaouchiche, Bernard</creatorcontrib><creatorcontrib>Michallet, Mauricette</creatorcontrib><creatorcontrib>Picot, Stephane</creatorcontrib><creatorcontrib>Bienvenu, Anne-Lise</creatorcontrib><creatorcontrib>Study Group</creatorcontrib><title>Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade</title><title>Medical mycology (Oxford)</title><addtitle>Med Mycol</addtitle><description>Since the outcomes of patients with candidemia is poor and Candida spp. with increased resistance to antifungal therapy may be associated with these results, the emergence of these blood infections caused by non-C. albicans Candida spp. was explored prospectively over a two-year period (2009-2010). Candidemia was defined as the recovery of Candida spp. in culture from a patient's blood sample. The in vitro susceptibility of each isolate to amphotericin B, caspofungin, fluconazole and voriconazole was determined. In addition, characteristics of patients and outcomes were investigated in real-time. The Candida distribution was compared to that observed in a similar study 10 years earlier in the same hospital. A total of 182 patients with candidemia were included in the study. While C. albicans was the most frequently isolated species (n = 102), non-C. albicans Candida spp. included; C. glabrata (n = 32), C. parapsilosis (n = 21), C. tropicalis (n = 13), C. krusei (n = 8), C. kefyr (n = 3), C. lusitaniae (n = 2), C. lipolytica (n = 2), C. famata (n = 1), C. guilliermondii (n = 1), C. inconspicua (n = 1), C. dubliniensis (n = 1), C. sake (n = 1) and C. nivariensis (n = 1). In seven patients, C. albicans was associated with another Candida spp. Surprisingly, this prospective study demonstrated that regardless of the department (intensive care unit or hematological department), Candida spp. distribution was no different from that found in the 1998-2001 survey, except for C. krusei. A reduction in the proportion of C. krusei isolates was observed from 2000-2010 (P = 0.028) as a result of its decreased recovery in the hematological department.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antifungal Agents - pharmacology</subject><subject>Bacteriology</subject><subject>Biodiversity</subject><subject>Candida - classification</subject><subject>Candida - drug effects</subject><subject>Candida - isolation & purification</subject><subject>Candida albicans - classification</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - isolation & purification</subject><subject>Candidemia - diagnosis</subject><subject>Candidemia - microbiology</subject><subject>Candidemia - mortality</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Demography</subject><subject>Drug Resistance, Fungal</subject><subject>Ecology, environment</subject><subject>Ecosystems</subject><subject>Epidemiological Monitoring</subject><subject>Female</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Infant</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Microbial Sensitivity Tests</subject><subject>Microbiology and Parasitology</subject><subject>Middle Aged</subject><subject>Populations and Evolution</subject><subject>Prospective Studies</subject><subject>Quantitative Methods</subject><subject>Risk Factors</subject><subject>Systematics, Phylogenetics and taxonomy</subject><subject>Young Adult</subject><issn>1369-3786</issn><issn>1460-2709</issn><issn>1365-280X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU9r3DAQxUVpaNK036AUH5uDNyPJ-uNLISxpU1jIpT2LWUnOKtjSVrIL_fbV4iSXQullNKP5vSfQI-QDhQ2n0F9TLnuutNwwoGwjtZSKvyIXtJPQMgX969pXpD0x5-RtKY8AVPWMvyHnjEkNvdIXxGwxuuCwwXEfLMbS1LmJKbZ_LYYlPvgpYBNihWotc5iXOaSIY3NI5Rjm2rglh_jQYOO8ReffkbMBx-LfP52X5MeX2-_bu3Z3__Xb9mbX2o7LuUUOijMKXGhLKQ6951KpDpRQ0CmtlBUDdQh0LwR4Ti2nGrRVA4h-7xzjl-Rq9T3gaI45TJh_m4TB3N3szOkOGOedUOoXreynlT3m9HPxZTZTKNaPI0aflmIo40qA0kJUtFtRm1Mp2Q8v3hTMKQbzHIM5xWDWGKrs49MLy37y7kX0_O8VuF6BtBz_1_LzqghxSHnCg8dxPljM3jymJdcMyr8N_gA4n6Gc</recordid><startdate>201301</startdate><enddate>201301</enddate><creator>Parmeland, Laurence</creator><creator>Gazon, Mathieu</creator><creator>Guerin, Claude</creator><creator>Argaud, Laurent</creator><creator>Lehot, Jean-Jacques</creator><creator>Bastien, Olivier</creator><creator>Allaouchiche, Bernard</creator><creator>Michallet, Mauricette</creator><creator>Picot, Stephane</creator><creator>Bienvenu, Anne-Lise</creator><general>Informa Healthcare</general><general>Informa UK Ltd</general><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-1962-0464</orcidid><orcidid>https://orcid.org/0000-0002-5735-6759</orcidid><orcidid>https://orcid.org/0000-0002-4953-9125</orcidid><orcidid>https://orcid.org/0000-0003-4700-6672</orcidid><orcidid>https://orcid.org/0000-0003-0988-1716</orcidid></search><sort><creationdate>201301</creationdate><title>Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade</title><author>Parmeland, Laurence ; Gazon, Mathieu ; Guerin, Claude ; Argaud, Laurent ; Lehot, Jean-Jacques ; Bastien, Olivier ; Allaouchiche, Bernard ; Michallet, Mauricette ; Picot, Stephane ; Bienvenu, Anne-Lise</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-a3073210358c11af9e367740757047877c5f1da01b550e31c31808c7f059bdd23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antifungal Agents - pharmacology</topic><topic>Bacteriology</topic><topic>Biodiversity</topic><topic>Candida - classification</topic><topic>Candida - drug effects</topic><topic>Candida - isolation & purification</topic><topic>Candida albicans - classification</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - isolation & purification</topic><topic>Candidemia - diagnosis</topic><topic>Candidemia - microbiology</topic><topic>Candidemia - mortality</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Demography</topic><topic>Drug Resistance, Fungal</topic><topic>Ecology, environment</topic><topic>Ecosystems</topic><topic>Epidemiological Monitoring</topic><topic>Female</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Infant</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Microbial Sensitivity Tests</topic><topic>Microbiology and Parasitology</topic><topic>Middle Aged</topic><topic>Populations and Evolution</topic><topic>Prospective Studies</topic><topic>Quantitative Methods</topic><topic>Risk Factors</topic><topic>Systematics, Phylogenetics and taxonomy</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parmeland, Laurence</creatorcontrib><creatorcontrib>Gazon, Mathieu</creatorcontrib><creatorcontrib>Guerin, Claude</creatorcontrib><creatorcontrib>Argaud, Laurent</creatorcontrib><creatorcontrib>Lehot, Jean-Jacques</creatorcontrib><creatorcontrib>Bastien, Olivier</creatorcontrib><creatorcontrib>Allaouchiche, Bernard</creatorcontrib><creatorcontrib>Michallet, Mauricette</creatorcontrib><creatorcontrib>Picot, Stephane</creatorcontrib><creatorcontrib>Bienvenu, Anne-Lise</creatorcontrib><creatorcontrib>Study Group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Medical mycology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parmeland, Laurence</au><au>Gazon, Mathieu</au><au>Guerin, Claude</au><au>Argaud, Laurent</au><au>Lehot, Jean-Jacques</au><au>Bastien, Olivier</au><au>Allaouchiche, Bernard</au><au>Michallet, Mauricette</au><au>Picot, Stephane</au><au>Bienvenu, Anne-Lise</au><aucorp>Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade</atitle><jtitle>Medical mycology (Oxford)</jtitle><addtitle>Med Mycol</addtitle><date>2013-01</date><risdate>2013</risdate><volume>51</volume><issue>1</issue><spage>33</spage><epage>37</epage><pages>33-37</pages><issn>1369-3786</issn><eissn>1460-2709</eissn><eissn>1365-280X</eissn><abstract>Since the outcomes of patients with candidemia is poor and Candida spp. with increased resistance to antifungal therapy may be associated with these results, the emergence of these blood infections caused by non-C. albicans Candida spp. was explored prospectively over a two-year period (2009-2010). Candidemia was defined as the recovery of Candida spp. in culture from a patient's blood sample. The in vitro susceptibility of each isolate to amphotericin B, caspofungin, fluconazole and voriconazole was determined. In addition, characteristics of patients and outcomes were investigated in real-time. The Candida distribution was compared to that observed in a similar study 10 years earlier in the same hospital. A total of 182 patients with candidemia were included in the study. While C. albicans was the most frequently isolated species (n = 102), non-C. albicans Candida spp. included; C. glabrata (n = 32), C. parapsilosis (n = 21), C. tropicalis (n = 13), C. krusei (n = 8), C. kefyr (n = 3), C. lusitaniae (n = 2), C. lipolytica (n = 2), C. famata (n = 1), C. guilliermondii (n = 1), C. inconspicua (n = 1), C. dubliniensis (n = 1), C. sake (n = 1) and C. nivariensis (n = 1). In seven patients, C. albicans was associated with another Candida spp. Surprisingly, this prospective study demonstrated that regardless of the department (intensive care unit or hematological department), Candida spp. distribution was no different from that found in the 1998-2001 survey, except for C. krusei. A reduction in the proportion of C. krusei isolates was observed from 2000-2010 (P = 0.028) as a result of its decreased recovery in the hematological department.</abstract><cop>UK</cop><pub>Informa Healthcare</pub><pmid>22680978</pmid><doi>10.3109/13693786.2012.686673</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-1962-0464</orcidid><orcidid>https://orcid.org/0000-0002-5735-6759</orcidid><orcidid>https://orcid.org/0000-0002-4953-9125</orcidid><orcidid>https://orcid.org/0000-0003-4700-6672</orcidid><orcidid>https://orcid.org/0000-0003-0988-1716</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1369-3786 |
| ispartof | Medical mycology (Oxford), 2013-01, Vol.51 (1), p.33-37 |
| issn | 1369-3786 1460-2709 1365-280X |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02334577v1 |
| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adolescent Adult Aged Aged, 80 and over Antifungal Agents - pharmacology Bacteriology Biodiversity Candida - classification Candida - drug effects Candida - isolation & purification Candida albicans - classification Candida albicans - drug effects Candida albicans - isolation & purification Candidemia - diagnosis Candidemia - microbiology Candidemia - mortality Child Child, Preschool Demography Drug Resistance, Fungal Ecology, environment Ecosystems Epidemiological Monitoring Female Hospitals Humans Infant Life Sciences Male Microbial Sensitivity Tests Microbiology and Parasitology Middle Aged Populations and Evolution Prospective Studies Quantitative Methods Risk Factors Systematics, Phylogenetics and taxonomy Young Adult |
| title | Candida albicans and non-Candida albicans fungemia in an institutional hospital during a decade |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T07%3A15%3A50IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Candida%20albicans%20and%20non-Candida%20albicans%20fungemia%20in%20an%20institutional%20hospital%20during%20a%20decade&rft.jtitle=Medical%20mycology%20(Oxford)&rft.au=Parmeland,%20Laurence&rft.aucorp=Study%20Group&rft.date=2013-01&rft.volume=51&rft.issue=1&rft.spage=33&rft.epage=37&rft.pages=33-37&rft.issn=1369-3786&rft.eissn=1460-2709&rft_id=info:doi/10.3109/13693786.2012.686673&rft_dat=%3Cproquest_hal_p%3E1237507855%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1237507855&rft_id=info:pmid/22680978&rft_oup_id=10.3109/13693786.2012.686673&rfr_iscdi=true |