Lipid oxidation induces structural changes in biomimetic membranes
Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, a natural metabolic outcome of life with oxygen under light, is also a salient oxidation reaction in photomedicine treatments. How...
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| Veröffentlicht in: | Soft matter 2014-06, Vol.10 (24), p.4241-4247 |
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| creator | Weber, Georges Charitat, Thierry Baptista, Maurício S Uchoa, Adjaci F Pavani, Christiane Junqueira, Helena C Guo, Yachong Baulin, Vladimir A Itri, Rosangela Marques, Carlos M Schroder, André P |
| description | Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, a natural metabolic outcome of life with oxygen under light, is also a salient oxidation reaction in photomedicine treatments. However, the effect of peroxidation on the fate of lipid membranes remains elusive. Here we use a new photosensitizer that anchors and disperses in the membrane to achieve spatial control of the oxidizing species. We find, surprisingly, that the integrity of unsaturated unilamellar vesicles is preserved even for fully oxidized membranes. Membrane survival allows for the quantification of the transformations of the peroxidized bilayers, providing key physical and chemical information to understand the effect of lipid oxidation on protein insertion and on other mechanisms of cell function. We anticipate that spatially controlled oxidation will emerge as a new powerful strategy for tuning and evaluating lipid membranes in biomimetic media under oxidative stress. |
| doi_str_mv | 10.1039/c3sm52740a |
| format | Article |
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Lipid peroxidation, a natural metabolic outcome of life with oxygen under light, is also a salient oxidation reaction in photomedicine treatments. However, the effect of peroxidation on the fate of lipid membranes remains elusive. Here we use a new photosensitizer that anchors and disperses in the membrane to achieve spatial control of the oxidizing species. We find, surprisingly, that the integrity of unsaturated unilamellar vesicles is preserved even for fully oxidized membranes. Membrane survival allows for the quantification of the transformations of the peroxidized bilayers, providing key physical and chemical information to understand the effect of lipid oxidation on protein insertion and on other mechanisms of cell function. We anticipate that spatially controlled oxidation will emerge as a new powerful strategy for tuning and evaluating lipid membranes in biomimetic media under oxidative stress.</description><identifier>ISSN: 1744-683X</identifier><identifier>EISSN: 1744-6848</identifier><identifier>DOI: 10.1039/c3sm52740a</identifier><identifier>PMID: 24871383</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Absorption, Radiation ; Anchors ; Condensed Matter ; Indoles - chemical synthesis ; Indoles - chemistry ; Insertion ; Lipid Peroxidation ; Lipids ; Membranes ; Oxidation ; Photosensitizing Agents - pharmacology ; Photosensitizing Agents - radiation effects ; Physics ; Porphyrins - chemical synthesis ; Porphyrins - chemistry ; Self assembly ; Soft Condensed Matter ; Transformations ; Tuning ; Ultraviolet Rays ; Unilamellar Liposomes - chemistry</subject><ispartof>Soft matter, 2014-06, Vol.10 (24), p.4241-4247</ispartof><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-8cb62ae5e7710d60a430bb1cf5e3bdca0456adbea3639ce8b274de665096878f3</citedby><cites>FETCH-LOGICAL-c354t-8cb62ae5e7710d60a430bb1cf5e3bdca0456adbea3639ce8b274de665096878f3</cites><orcidid>0000-0003-3167-6495 ; 0000-0002-3952-0498 ; 0000-0002-7962-4507</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24871383$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02333891$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Weber, Georges</creatorcontrib><creatorcontrib>Charitat, Thierry</creatorcontrib><creatorcontrib>Baptista, Maurício S</creatorcontrib><creatorcontrib>Uchoa, Adjaci F</creatorcontrib><creatorcontrib>Pavani, Christiane</creatorcontrib><creatorcontrib>Junqueira, Helena C</creatorcontrib><creatorcontrib>Guo, Yachong</creatorcontrib><creatorcontrib>Baulin, Vladimir A</creatorcontrib><creatorcontrib>Itri, Rosangela</creatorcontrib><creatorcontrib>Marques, Carlos M</creatorcontrib><creatorcontrib>Schroder, André P</creatorcontrib><title>Lipid oxidation induces structural changes in biomimetic membranes</title><title>Soft matter</title><addtitle>Soft Matter</addtitle><description>Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, a natural metabolic outcome of life with oxygen under light, is also a salient oxidation reaction in photomedicine treatments. However, the effect of peroxidation on the fate of lipid membranes remains elusive. Here we use a new photosensitizer that anchors and disperses in the membrane to achieve spatial control of the oxidizing species. We find, surprisingly, that the integrity of unsaturated unilamellar vesicles is preserved even for fully oxidized membranes. Membrane survival allows for the quantification of the transformations of the peroxidized bilayers, providing key physical and chemical information to understand the effect of lipid oxidation on protein insertion and on other mechanisms of cell function. We anticipate that spatially controlled oxidation will emerge as a new powerful strategy for tuning and evaluating lipid membranes in biomimetic media under oxidative stress.</description><subject>Absorption, Radiation</subject><subject>Anchors</subject><subject>Condensed Matter</subject><subject>Indoles - chemical synthesis</subject><subject>Indoles - chemistry</subject><subject>Insertion</subject><subject>Lipid Peroxidation</subject><subject>Lipids</subject><subject>Membranes</subject><subject>Oxidation</subject><subject>Photosensitizing Agents - pharmacology</subject><subject>Photosensitizing Agents - radiation effects</subject><subject>Physics</subject><subject>Porphyrins - chemical synthesis</subject><subject>Porphyrins - chemistry</subject><subject>Self assembly</subject><subject>Soft Condensed Matter</subject><subject>Transformations</subject><subject>Tuning</subject><subject>Ultraviolet Rays</subject><subject>Unilamellar Liposomes - chemistry</subject><issn>1744-683X</issn><issn>1744-6848</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9LxDAQxYMo7vrn4geQHlWoJp0kTY_roq5Q8KLgLSRp6kaadk1a0W9vl13Xo6cZht883sxD6Izga4KhuDEQPctyitUempKc0pQLKvZ3PbxO0FGM7xiDoIQfoklGRU5AwBTdlm7lqqT7cpXqXdcmrq0GY2MS-zCYfgiqScxStW_jyLWJdp133vbOJN56HVRr4wk6qFUT7em2HqOX-7vn-SItnx4e57MyNcBonwqjeaYss3lOcMWxooC1JqZmFnRlFKaMq0pbBRwKY4UeL6os5wwXXOSihmN0udFdqkaugvMqfMtOObmYlXI9wxkAiIJ8kpG92LCr0H0MNvbSu2hs04yGuyFKwhjBBS3Gjf9RwAUjFLIRvdqgJnQxBlvvbBAs11HIvyhG-HyrO2hvqx36-3v4Aerfg5c</recordid><startdate>20140628</startdate><enddate>20140628</enddate><creator>Weber, Georges</creator><creator>Charitat, Thierry</creator><creator>Baptista, Maurício S</creator><creator>Uchoa, Adjaci F</creator><creator>Pavani, Christiane</creator><creator>Junqueira, Helena C</creator><creator>Guo, Yachong</creator><creator>Baulin, Vladimir A</creator><creator>Itri, Rosangela</creator><creator>Marques, Carlos M</creator><creator>Schroder, André P</creator><general>Royal Society of Chemistry</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0003-3167-6495</orcidid><orcidid>https://orcid.org/0000-0002-3952-0498</orcidid><orcidid>https://orcid.org/0000-0002-7962-4507</orcidid></search><sort><creationdate>20140628</creationdate><title>Lipid oxidation induces structural changes in biomimetic membranes</title><author>Weber, Georges ; Charitat, Thierry ; Baptista, Maurício S ; Uchoa, Adjaci F ; Pavani, Christiane ; Junqueira, Helena C ; Guo, Yachong ; Baulin, Vladimir A ; Itri, Rosangela ; Marques, Carlos M ; Schroder, André P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-8cb62ae5e7710d60a430bb1cf5e3bdca0456adbea3639ce8b274de665096878f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Absorption, Radiation</topic><topic>Anchors</topic><topic>Condensed Matter</topic><topic>Indoles - chemical synthesis</topic><topic>Indoles - chemistry</topic><topic>Insertion</topic><topic>Lipid Peroxidation</topic><topic>Lipids</topic><topic>Membranes</topic><topic>Oxidation</topic><topic>Photosensitizing Agents - pharmacology</topic><topic>Photosensitizing Agents - radiation effects</topic><topic>Physics</topic><topic>Porphyrins - chemical synthesis</topic><topic>Porphyrins - chemistry</topic><topic>Self assembly</topic><topic>Soft Condensed Matter</topic><topic>Transformations</topic><topic>Tuning</topic><topic>Ultraviolet Rays</topic><topic>Unilamellar Liposomes - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Weber, Georges</creatorcontrib><creatorcontrib>Charitat, Thierry</creatorcontrib><creatorcontrib>Baptista, Maurício S</creatorcontrib><creatorcontrib>Uchoa, Adjaci F</creatorcontrib><creatorcontrib>Pavani, Christiane</creatorcontrib><creatorcontrib>Junqueira, Helena C</creatorcontrib><creatorcontrib>Guo, Yachong</creatorcontrib><creatorcontrib>Baulin, Vladimir A</creatorcontrib><creatorcontrib>Itri, Rosangela</creatorcontrib><creatorcontrib>Marques, Carlos M</creatorcontrib><creatorcontrib>Schroder, André P</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Soft matter</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Weber, Georges</au><au>Charitat, Thierry</au><au>Baptista, Maurício S</au><au>Uchoa, Adjaci F</au><au>Pavani, Christiane</au><au>Junqueira, Helena C</au><au>Guo, Yachong</au><au>Baulin, Vladimir A</au><au>Itri, Rosangela</au><au>Marques, Carlos M</au><au>Schroder, André P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid oxidation induces structural changes in biomimetic membranes</atitle><jtitle>Soft matter</jtitle><addtitle>Soft Matter</addtitle><date>2014-06-28</date><risdate>2014</risdate><volume>10</volume><issue>24</issue><spage>4241</spage><epage>4247</epage><pages>4241-4247</pages><issn>1744-683X</issn><eissn>1744-6848</eissn><abstract>Oxidation can intimately influence and structurally compromise the levels of biological self-assembly embodied by intracellular and plasma membranes. Lipid peroxidation, a natural metabolic outcome of life with oxygen under light, is also a salient oxidation reaction in photomedicine treatments. However, the effect of peroxidation on the fate of lipid membranes remains elusive. Here we use a new photosensitizer that anchors and disperses in the membrane to achieve spatial control of the oxidizing species. We find, surprisingly, that the integrity of unsaturated unilamellar vesicles is preserved even for fully oxidized membranes. Membrane survival allows for the quantification of the transformations of the peroxidized bilayers, providing key physical and chemical information to understand the effect of lipid oxidation on protein insertion and on other mechanisms of cell function. 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| source | MEDLINE; Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection |
| subjects | Absorption, Radiation Anchors Condensed Matter Indoles - chemical synthesis Indoles - chemistry Insertion Lipid Peroxidation Lipids Membranes Oxidation Photosensitizing Agents - pharmacology Photosensitizing Agents - radiation effects Physics Porphyrins - chemical synthesis Porphyrins - chemistry Self assembly Soft Condensed Matter Transformations Tuning Ultraviolet Rays Unilamellar Liposomes - chemistry |
| title | Lipid oxidation induces structural changes in biomimetic membranes |
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