Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study
Summary Background IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce. Aim To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60. Methods Using EPIMA...
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| Veröffentlicht in: | Alimentary Pharmacology & Therapeutics (Suppl) 2018-06, Vol.47 (12), p.1652-1660 |
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| creator | Sacleux, S.‐C. Guillon‐Dellac, N. Gower‐Rousseau, C. Aroichane, I Assi, F Baudet, A Bebahani, A Becqwort, JP Ben Soussan, E Berkelmans, I Bernou, K Bismuth, B Boualit, M Bourgeois, M Branche, J Bray, G Bulois, P Butel, J Canva, JY Carpentier, P Cartier, E Cassar, JF Cassagnou, M Catteau, S Caujolle, B Chandelier, C Charles, J Charneau, T Chavance‐Thelu, M Claerbout, JF Clergue, PY Debas, J Delcenserie, R Desmet, P Desreumaux, P Devienne, A Dharancy, S Ducatillon, P Ducrot, F Dufilho, A Duriez, A Elie‐Legrand, MC Fatome, A Filoche, B Flahaut, M Flamme, C Frere, T Gallet, P Gamblin, C Gillet, B Godchaux, R Goegebeur, G Goria, O Gottrand, F Guillard, JF Hecquet, G Houssin‐Bailly, L Joly, JP Kerleveo, A Laffineur, G Lagarde, M Lapchin, J Leblanc, R Legrand, C Lelong, P Leroi, H Lesage, J Lisambert, B Maillard, D Mancheron, H Marks‐Brunel, AB Marti, R Metayer, P Mirmaran, X Modaine, P Morel, L Moulin, E N'Guyen Khac, E Ouvry, D Paillot, B Paupart, L Plane, C Plouvier, B Pollet, E Prevost, JC Richez, C Roger, J Shekh, N Spyckerelle, C Thiebault, H Tode, M Touchais, JY Turck, D Valmage, C Vandevenne, P Vermelle, P Vezilier‐Cocq, P Weber, J Willocquet, JL Zaouri, B |
| description | Summary
Background
IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce.
Aim
To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60.
Methods
Using EPIMAD Cohort (1988‐2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC).
Results
After a median post‐operative follow‐up of 6 years (2‐10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post‐operative days, the mortality rate was 4%. Thirty‐two early complications (grade 2) without significant difference between CD and UC (P = 0.28). Thirty‐seven long‐term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15‐28.52]) and emergency surgery (OR = 4.46 [1.75‐11.36]) were associated with early post‐operative complications, and (2) Female gender (HR = 2.10 [1.01‐4.37]) and delay before surgery >3 months (HR = 2.09 [1.01‐4.31]) with long‐term adverse effects of surgical therapy.
Conclusions
One‐third of elderly IBD patients experienced at least 1 post‐operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post‐operative complication.
Linked ContentThis article is linked to Myrelid and Savoye et al papers. To view these articles visit https://doi.org/10.1111/apt.14833 and https://doi.org/10.1111/apt.14854. |
| doi_str_mv | 10.1111/apt.14790 |
| format | Article |
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Background
IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce.
Aim
To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60.
Methods
Using EPIMAD Cohort (1988‐2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC).
Results
After a median post‐operative follow‐up of 6 years (2‐10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post‐operative days, the mortality rate was 4%. Thirty‐two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post‐operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty‐seven long‐term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15‐28.52]) and emergency surgery (OR = 4.46 [1.75‐11.36]) were associated with early post‐operative complications, and (2) Female gender (HR = 2.10 [1.01‐4.37]) and delay before surgery >3 months (HR = 2.09 [1.01‐4.31]) with long‐term adverse effects of surgical therapy.
Conclusions
One‐third of elderly IBD patients experienced at least 1 post‐operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post‐operative complication.
Linked ContentThis article is linked to Myrelid and Savoye et al papers. To view these articles visit https://doi.org/10.1111/apt.14833 and https://doi.org/10.1111/apt.14854.</description><identifier>ISSN: 0269-2813</identifier><identifier>ISSN: 0953-0673</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/apt.14790</identifier><identifier>PMID: 29737553</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Aged ; Cohort Studies ; Colitis, Ulcerative/epidemiology ; Colitis, Ulcerative/surgery ; Complications ; Crohn Disease/epidemiology ; Crohn Disease/surgery ; Crohn's disease ; Digestive System Surgical Procedures/methods ; Female ; Geriatrics ; Human health and pathology ; Humans ; Hépatology and Gastroenterology ; Incidence ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases/epidemiology ; Inflammatory Bowel Diseases/surgery ; Intestine ; Life Sciences ; Male ; Middle Aged ; Multivariate analysis ; Older people ; Population studies ; Population-based studies ; Postoperative Complications/epidemiology ; Retrospective Studies ; Risk Factors ; Side effects ; Surgery ; Ulcerative colitis</subject><ispartof>Alimentary Pharmacology & Therapeutics (Suppl), 2018-06, Vol.47 (12), p.1652-1660</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4880-af0801dfbe527998c406de0d58f2954c7ab9a457e3fe737f3e75b58cc40fab0c3</citedby><cites>FETCH-LOGICAL-c4880-af0801dfbe527998c406de0d58f2954c7ab9a457e3fe737f3e75b58cc40fab0c3</cites><orcidid>0000-0002-7251-1542 ; 0000-0003-1442-0244 ; 0000-0003-2536-6618 ; 0000-0002-2337-2902</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fapt.14790$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fapt.14790$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,315,782,786,887,1419,1435,27933,27934,45583,45584,46418,46842</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29737553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-02333082$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Sacleux, S.‐C.</creatorcontrib><creatorcontrib>Guillon‐Dellac, N.</creatorcontrib><creatorcontrib>Gower‐Rousseau, C.</creatorcontrib><creatorcontrib>Aroichane, I</creatorcontrib><creatorcontrib>Assi, F</creatorcontrib><creatorcontrib>Baudet, A</creatorcontrib><creatorcontrib>Bebahani, A</creatorcontrib><creatorcontrib>Becqwort, JP</creatorcontrib><creatorcontrib>Ben Soussan, E</creatorcontrib><creatorcontrib>Berkelmans, I</creatorcontrib><creatorcontrib>Bernou, K</creatorcontrib><creatorcontrib>Bismuth, B</creatorcontrib><creatorcontrib>Boualit, M</creatorcontrib><creatorcontrib>Bourgeois, M</creatorcontrib><creatorcontrib>Branche, J</creatorcontrib><creatorcontrib>Bray, G</creatorcontrib><creatorcontrib>Bulois, P</creatorcontrib><creatorcontrib>Butel, J</creatorcontrib><creatorcontrib>Canva, JY</creatorcontrib><creatorcontrib>Carpentier, P</creatorcontrib><creatorcontrib>Cartier, E</creatorcontrib><creatorcontrib>Cassar, JF</creatorcontrib><creatorcontrib>Cassagnou, M</creatorcontrib><creatorcontrib>Catteau, S</creatorcontrib><creatorcontrib>Caujolle, B</creatorcontrib><creatorcontrib>Chandelier, C</creatorcontrib><creatorcontrib>Charles, J</creatorcontrib><creatorcontrib>Charneau, T</creatorcontrib><creatorcontrib>Chavance‐Thelu, M</creatorcontrib><creatorcontrib>Claerbout, JF</creatorcontrib><creatorcontrib>Clergue, PY</creatorcontrib><creatorcontrib>Debas, J</creatorcontrib><creatorcontrib>Delcenserie, R</creatorcontrib><creatorcontrib>Desmet, P</creatorcontrib><creatorcontrib>Desreumaux, P</creatorcontrib><creatorcontrib>Devienne, A</creatorcontrib><creatorcontrib>Dharancy, S</creatorcontrib><creatorcontrib>Ducatillon, P</creatorcontrib><creatorcontrib>Ducrot, F</creatorcontrib><creatorcontrib>Dufilho, A</creatorcontrib><creatorcontrib>Duriez, A</creatorcontrib><creatorcontrib>Elie‐Legrand, MC</creatorcontrib><creatorcontrib>Fatome, A</creatorcontrib><creatorcontrib>Filoche, B</creatorcontrib><creatorcontrib>Flahaut, M</creatorcontrib><creatorcontrib>Flamme, C</creatorcontrib><creatorcontrib>Frere, T</creatorcontrib><creatorcontrib>Gallet, P</creatorcontrib><creatorcontrib>Gamblin, C</creatorcontrib><creatorcontrib>Gillet, B</creatorcontrib><creatorcontrib>Godchaux, R</creatorcontrib><creatorcontrib>Goegebeur, G</creatorcontrib><creatorcontrib>Goria, O</creatorcontrib><creatorcontrib>Gottrand, F</creatorcontrib><creatorcontrib>Guillard, JF</creatorcontrib><creatorcontrib>Hecquet, G</creatorcontrib><creatorcontrib>Houssin‐Bailly, L</creatorcontrib><creatorcontrib>Joly, JP</creatorcontrib><creatorcontrib>Kerleveo, A</creatorcontrib><creatorcontrib>Laffineur, G</creatorcontrib><creatorcontrib>Lagarde, M</creatorcontrib><creatorcontrib>Lapchin, J</creatorcontrib><creatorcontrib>Leblanc, R</creatorcontrib><creatorcontrib>Legrand, C</creatorcontrib><creatorcontrib>Lelong, P</creatorcontrib><creatorcontrib>Leroi, H</creatorcontrib><creatorcontrib>Lesage, J</creatorcontrib><creatorcontrib>Lisambert, B</creatorcontrib><creatorcontrib>Maillard, D</creatorcontrib><creatorcontrib>Mancheron, H</creatorcontrib><creatorcontrib>Marks‐Brunel, AB</creatorcontrib><creatorcontrib>Marti, R</creatorcontrib><creatorcontrib>Metayer, P</creatorcontrib><creatorcontrib>Mirmaran, X</creatorcontrib><creatorcontrib>Modaine, P</creatorcontrib><creatorcontrib>Morel, L</creatorcontrib><creatorcontrib>Moulin, E</creatorcontrib><creatorcontrib>N'Guyen Khac, E</creatorcontrib><creatorcontrib>Ouvry, D</creatorcontrib><creatorcontrib>Paillot, B</creatorcontrib><creatorcontrib>Paupart, L</creatorcontrib><creatorcontrib>Plane, C</creatorcontrib><creatorcontrib>Plouvier, B</creatorcontrib><creatorcontrib>Pollet, E</creatorcontrib><creatorcontrib>Prevost, JC</creatorcontrib><creatorcontrib>Richez, C</creatorcontrib><creatorcontrib>Roger, J</creatorcontrib><creatorcontrib>Shekh, N</creatorcontrib><creatorcontrib>Spyckerelle, C</creatorcontrib><creatorcontrib>Thiebault, H</creatorcontrib><creatorcontrib>Tode, M</creatorcontrib><creatorcontrib>Touchais, JY</creatorcontrib><creatorcontrib>Turck, D</creatorcontrib><creatorcontrib>Valmage, C</creatorcontrib><creatorcontrib>Vandevenne, P</creatorcontrib><creatorcontrib>Vermelle, P</creatorcontrib><creatorcontrib>Vezilier‐Cocq, P</creatorcontrib><creatorcontrib>Weber, J</creatorcontrib><creatorcontrib>Willocquet, JL</creatorcontrib><creatorcontrib>Zaouri, B</creatorcontrib><creatorcontrib>EPIMAD Group</creatorcontrib><creatorcontrib>the EPIMAD Group</creatorcontrib><title>Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study</title><title>Alimentary Pharmacology & Therapeutics (Suppl)</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background
IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce.
Aim
To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60.
Methods
Using EPIMAD Cohort (1988‐2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC).
Results
After a median post‐operative follow‐up of 6 years (2‐10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post‐operative days, the mortality rate was 4%. Thirty‐two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post‐operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty‐seven long‐term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15‐28.52]) and emergency surgery (OR = 4.46 [1.75‐11.36]) were associated with early post‐operative complications, and (2) Female gender (HR = 2.10 [1.01‐4.37]) and delay before surgery >3 months (HR = 2.09 [1.01‐4.31]) with long‐term adverse effects of surgical therapy.
Conclusions
One‐third of elderly IBD patients experienced at least 1 post‐operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post‐operative complication.
Linked ContentThis article is linked to Myrelid and Savoye et al papers. To view these articles visit https://doi.org/10.1111/apt.14833 and https://doi.org/10.1111/apt.14854.</description><subject>Aged</subject><subject>Cohort Studies</subject><subject>Colitis, Ulcerative/epidemiology</subject><subject>Colitis, Ulcerative/surgery</subject><subject>Complications</subject><subject>Crohn Disease/epidemiology</subject><subject>Crohn Disease/surgery</subject><subject>Crohn's disease</subject><subject>Digestive System Surgical Procedures/methods</subject><subject>Female</subject><subject>Geriatrics</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hépatology and Gastroenterology</subject><subject>Incidence</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases/epidemiology</subject><subject>Inflammatory Bowel Diseases/surgery</subject><subject>Intestine</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Older people</subject><subject>Population studies</subject><subject>Population-based studies</subject><subject>Postoperative Complications/epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Side effects</subject><subject>Surgery</subject><subject>Ulcerative colitis</subject><issn>0269-2813</issn><issn>0953-0673</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kc1O3DAUha2KCgbaRV-gssSmLAI3dhwn7EaolEojwQLWluNcq0HOONgJKDseoc_YJ8HD8CMh1ZJl3aPP5_r6EPIth-M8rRM9jMd5IWv4RBY5L0XGgJc7ZAGsrDNW5XyP7Md4CwClBLZL9lgtuRSCL4i98nH89_jXDxj02N0jNb4fXGdS4deRdmuKrsXgZppKHJNgne57Pfow08Y_oKNtF1FHPKWaDn6Y3PPV5NkksaVxnNr5C_lstYv49eU8IDfnP6_PLrLV5a_fZ8tVZoqqgkxbqCBvbYOCybquTAFli9CKyrJaFEbqptaFkMgtpgksRykaUZnEWd2A4QfkaOv7Rzs1hK7XYVZed-piuVIbDRjnHCp2nyf2x5Ydgr-bMI6q76JB5_Qa_RTV5hPT5qxI6OEH9NZPYZ0mSVQheSmLsnxvboKPMaB9e0EOahOUSkGp56AS-_3FcWp6bN_I12QScLIFHjqH8_-d1PLqemv5BNA4nxw</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Sacleux, S.‐C.</creator><creator>Guillon‐Dellac, N.</creator><creator>Gower‐Rousseau, C.</creator><creator>Aroichane, I</creator><creator>Assi, F</creator><creator>Baudet, A</creator><creator>Bebahani, 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Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-7251-1542</orcidid><orcidid>https://orcid.org/0000-0003-1442-0244</orcidid><orcidid>https://orcid.org/0000-0003-2536-6618</orcidid><orcidid>https://orcid.org/0000-0002-2337-2902</orcidid></search><sort><creationdate>201806</creationdate><title>Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study</title><author>Sacleux, S.‐C. ; Guillon‐Dellac, N. ; Gower‐Rousseau, C. ; Aroichane, I ; Assi, F ; Baudet, A ; Bebahani, A ; Becqwort, JP ; Ben Soussan, E ; Berkelmans, I ; Bernou, K ; Bismuth, B ; Boualit, M ; Bourgeois, M ; Branche, J ; Bray, G ; Bulois, P ; Butel, J ; Canva, JY ; Carpentier, P ; Cartier, E ; Cassar, JF ; Cassagnou, M ; Catteau, S ; Caujolle, B ; Chandelier, C ; Charles, J ; Charneau, T ; Chavance‐Thelu, M ; Claerbout, JF ; Clergue, PY ; Debas, J ; Delcenserie, R ; Desmet, P ; Desreumaux, P ; Devienne, A ; Dharancy, S ; Ducatillon, P ; Ducrot, F ; Dufilho, A ; Duriez, A ; Elie‐Legrand, MC ; Fatome, A ; Filoche, B ; Flahaut, M ; Flamme, C ; Frere, T ; Gallet, P ; Gamblin, C ; Gillet, B ; Godchaux, R ; Goegebeur, G ; Goria, O ; Gottrand, F ; Guillard, JF ; Hecquet, G ; Houssin‐Bailly, L ; Joly, JP ; Kerleveo, A ; Laffineur, G ; Lagarde, M ; Lapchin, J ; Leblanc, R ; Legrand, C ; Lelong, P ; Leroi, H ; Lesage, J ; Lisambert, B ; Maillard, D ; Mancheron, H ; Marks‐Brunel, AB ; Marti, R ; Metayer, P ; Mirmaran, X ; Modaine, P ; Morel, L ; Moulin, E ; N'Guyen Khac, E ; Ouvry, D ; Paillot, B ; Paupart, L ; Plane, C ; Plouvier, B ; Pollet, E ; Prevost, JC ; Richez, C ; Roger, J ; Shekh, N ; Spyckerelle, C ; Thiebault, H ; Tode, M ; Touchais, JY ; Turck, D ; Valmage, C ; Vandevenne, P ; Vermelle, P ; Vezilier‐Cocq, P ; Weber, J ; Willocquet, JL ; Zaouri, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4880-af0801dfbe527998c406de0d58f2954c7ab9a457e3fe737f3e75b58cc40fab0c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aged</topic><topic>Cohort Studies</topic><topic>Colitis, Ulcerative/epidemiology</topic><topic>Colitis, Ulcerative/surgery</topic><topic>Complications</topic><topic>Crohn Disease/epidemiology</topic><topic>Crohn Disease/surgery</topic><topic>Crohn's disease</topic><topic>Digestive System Surgical Procedures/methods</topic><topic>Female</topic><topic>Geriatrics</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Hépatology and Gastroenterology</topic><topic>Incidence</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases/epidemiology</topic><topic>Inflammatory Bowel 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Group</creatorcontrib><creatorcontrib>the EPIMAD Group</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Alimentary Pharmacology & Therapeutics (Suppl)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sacleux, S.‐C.</au><au>Guillon‐Dellac, N.</au><au>Gower‐Rousseau, C.</au><au>Aroichane, I</au><au>Assi, F</au><au>Baudet, A</au><au>Bebahani, A</au><au>Becqwort, JP</au><au>Ben Soussan, E</au><au>Berkelmans, I</au><au>Bernou, K</au><au>Bismuth, B</au><au>Boualit, M</au><au>Bourgeois, M</au><au>Branche, J</au><au>Bray, G</au><au>Bulois, P</au><au>Butel, J</au><au>Canva, JY</au><au>Carpentier, P</au><au>Cartier, E</au><au>Cassar, JF</au><au>Cassagnou, M</au><au>Catteau, S</au><au>Caujolle, B</au><au>Chandelier, C</au><au>Charles, J</au><au>Charneau, T</au><au>Chavance‐Thelu, M</au><au>Claerbout, JF</au><au>Clergue, PY</au><au>Debas, J</au><au>Delcenserie, R</au><au>Desmet, P</au><au>Desreumaux, P</au><au>Devienne, A</au><au>Dharancy, S</au><au>Ducatillon, P</au><au>Ducrot, F</au><au>Dufilho, A</au><au>Duriez, A</au><au>Elie‐Legrand, MC</au><au>Fatome, A</au><au>Filoche, B</au><au>Flahaut, M</au><au>Flamme, C</au><au>Frere, T</au><au>Gallet, P</au><au>Gamblin, C</au><au>Gillet, B</au><au>Godchaux, R</au><au>Goegebeur, G</au><au>Goria, O</au><au>Gottrand, F</au><au>Guillard, JF</au><au>Hecquet, G</au><au>Houssin‐Bailly, L</au><au>Joly, JP</au><au>Kerleveo, A</au><au>Laffineur, G</au><au>Lagarde, M</au><au>Lapchin, J</au><au>Leblanc, R</au><au>Legrand, C</au><au>Lelong, P</au><au>Leroi, H</au><au>Lesage, J</au><au>Lisambert, B</au><au>Maillard, D</au><au>Mancheron, H</au><au>Marks‐Brunel, AB</au><au>Marti, R</au><au>Metayer, P</au><au>Mirmaran, X</au><au>Modaine, P</au><au>Morel, L</au><au>Moulin, E</au><au>N'Guyen Khac, E</au><au>Ouvry, D</au><au>Paillot, B</au><au>Paupart, L</au><au>Plane, C</au><au>Plouvier, B</au><au>Pollet, E</au><au>Prevost, JC</au><au>Richez, C</au><au>Roger, J</au><au>Shekh, N</au><au>Spyckerelle, C</au><au>Thiebault, H</au><au>Tode, M</au><au>Touchais, JY</au><au>Turck, D</au><au>Valmage, C</au><au>Vandevenne, P</au><au>Vermelle, P</au><au>Vezilier‐Cocq, P</au><au>Weber, J</au><au>Willocquet, JL</au><au>Zaouri, B</au><aucorp>EPIMAD Group</aucorp><aucorp>the EPIMAD Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study</atitle><jtitle>Alimentary Pharmacology & Therapeutics (Suppl)</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2018-06</date><risdate>2018</risdate><volume>47</volume><issue>12</issue><spage>1652</spage><epage>1660</epage><pages>1652-1660</pages><issn>0269-2813</issn><issn>0953-0673</issn><eissn>1365-2036</eissn><abstract>Summary
Background
IBD diagnosed after the age of 60 is increasing. Data on post‐operative complications in elderly onset IBD are scarce.
Aim
To describe the incidence of and factors associated with post‐operative complications in elderly onset IBD, diagnosed after the age of 60.
Methods
Using EPIMAD Cohort (1988‐2006), among 841 incident IBD patients, 139 (17%) underwent intestinal surgery, including 100 Crohn's disease (CD) and 39 ulcerative colitis (UC).
Results
After a median post‐operative follow‐up of 6 years (2‐10), 50 (36%) patients experienced at least 1 complication with a total of 69. During the first 30 post‐operative days, the mortality rate was 4%. Thirty‐two early complications (<30 days) were observed in 23 patients (17%), with 15 infectious, without significant difference between CD and UC. More than half early post‐operative complications (n = 19, 59%) were severe (>grade 2) without significant difference between CD and UC (P = 0.28). Thirty‐seven long‐term adverse effects of surgical therapy (≥30 days) were observed in 33 patients (24%). Multivariate analysis found (1) acute severe colitis (OR = 7.84 [2.15‐28.52]) and emergency surgery (OR = 4.46 [1.75‐11.36]) were associated with early post‐operative complications, and (2) Female gender (HR = 2.10 [1.01‐4.37]) and delay before surgery >3 months (HR = 2.09 [1.01‐4.31]) with long‐term adverse effects of surgical therapy.
Conclusions
One‐third of elderly IBD patients experienced at least 1 post‐operative complication. Half of the early complications were severe, and infectious. Emergency surgery was the key driver for post‐operative complication.
Linked ContentThis article is linked to Myrelid and Savoye et al papers. To view these articles visit https://doi.org/10.1111/apt.14833 and https://doi.org/10.1111/apt.14854.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29737553</pmid><doi>10.1111/apt.14790</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-7251-1542</orcidid><orcidid>https://orcid.org/0000-0003-1442-0244</orcidid><orcidid>https://orcid.org/0000-0003-2536-6618</orcidid><orcidid>https://orcid.org/0000-0002-2337-2902</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary Pharmacology & Therapeutics (Suppl), 2018-06, Vol.47 (12), p.1652-1660 |
| issn | 0269-2813 0953-0673 1365-2036 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02333082v1 |
| source | Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Aged Cohort Studies Colitis, Ulcerative/epidemiology Colitis, Ulcerative/surgery Complications Crohn Disease/epidemiology Crohn Disease/surgery Crohn's disease Digestive System Surgical Procedures/methods Female Geriatrics Human health and pathology Humans Hépatology and Gastroenterology Incidence Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases/epidemiology Inflammatory Bowel Diseases/surgery Intestine Life Sciences Male Middle Aged Multivariate analysis Older people Population studies Population-based studies Postoperative Complications/epidemiology Retrospective Studies Risk Factors Side effects Surgery Ulcerative colitis |
| title | Post‐operative complications in elderly onset inflammatory bowel disease: a population‐based study |
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