Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study
Background Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pa...
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| Veröffentlicht in: | Neurogastroenterology and motility 2018-06, Vol.30 (6), p.e13290-n/a |
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| creator | Melchior, C. Bril, L. Leroi, A‐M. Gourcerol, G. Ducrotté, P. |
| description | Background
Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity.
Methods
This prospective study included consecutive IBS patients selected by Rome III criteria. Validated scores (IBS‐SSS, Bristol stool scale, HADS) were used to phenotype patients who were also asked to describe the main location of their abdominal pain on a simple image (abdomen divided into 6 zones). Progressive isobaric rectal distensions were performed to demonstrate, with the ascending method of limits, allodynia (pain threshold lower than 24 mmHg).
Key Results
Fifty patients (women: 72%), 42.6 ± 15.7 years old, were included. Sub‐types were IBS‐D, IBS‐C and IBS‐M in 58%, 22% and 20% of cases, respectively. Allodynia was present in 18% of cases. Neither IBS‐SSS nor intensity of pain was predictive of hypersensitivity. In hypersensitive patients, pain was more often located in one of the two iliac fossa (P = 0.02) and located outside these areas in only 11% of cases. The sensitivity and the specificity of this pain location to differentiate hyper from normosensitive patients were 0.89 and 0.59, respectively.
Conclusions & Inferences
The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.
The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity. The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive. |
| doi_str_mv | 10.1111/nmo.13290 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02332153v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2047446600</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3870-841e0347b14b8d7d9685935c5610c7e12a81263c782f82f2dcd993a2f02fcca93</originalsourceid><addsrcrecordid>eNp1kd-K1TAQxoso7rp64QtIwBu96G7-NW2u5LCoKxxdEL0OaTqlWdKmJuk59GF8V3PsuoJgCGRIfvPNTL6ieEnwJcnrahr9JWFU4kfFOWGiKqls6ONTXOGSSFqdFc9ivMMYC8rF0-KMSsYrjsl58XMXAJlBB20SBBuTNRH5Hum286OdtEOzthMawM394lDyyHYwJduv-SHZHEZ0tGlABxsNhMwP6wwhwhRtsgebVpTTbQg26dYBav0RHIrr1AU_wjv0FeLi0lYSzcHHGUzOAxTT0q3Piye9dhFe3J8XxfcP779d35T724-frnf70rCmxmXDCWDG65bwtunqToqmkqwylSDY1ECobggVzNQN7fOmnemkZJr2mPbGaMkuireb7qCdmoMddViV11bd7PbqdIcpY5RU7EAy-2Zjc7c_FohJjafRndMT-CUqIhtZSS44zujrf9A7v4T8qVFRzGvOhcD4b3GTx48B-ocOCFYnf1X2V_32N7Ov7hWXdoTugfxjaAauNuBoHaz_V1JfPt9ukr8A-DGxCg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2047446600</pqid></control><display><type>article</type><title>Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study</title><source>Access via Wiley Online Library</source><source>Wiley Online Library (Open Access Collection)</source><creator>Melchior, C. ; Bril, L. ; Leroi, A‐M. ; Gourcerol, G. ; Ducrotté, P.</creator><creatorcontrib>Melchior, C. ; Bril, L. ; Leroi, A‐M. ; Gourcerol, G. ; Ducrotté, P.</creatorcontrib><description>Background
Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity.
Methods
This prospective study included consecutive IBS patients selected by Rome III criteria. Validated scores (IBS‐SSS, Bristol stool scale, HADS) were used to phenotype patients who were also asked to describe the main location of their abdominal pain on a simple image (abdomen divided into 6 zones). Progressive isobaric rectal distensions were performed to demonstrate, with the ascending method of limits, allodynia (pain threshold lower than 24 mmHg).
Key Results
Fifty patients (women: 72%), 42.6 ± 15.7 years old, were included. Sub‐types were IBS‐D, IBS‐C and IBS‐M in 58%, 22% and 20% of cases, respectively. Allodynia was present in 18% of cases. Neither IBS‐SSS nor intensity of pain was predictive of hypersensitivity. In hypersensitive patients, pain was more often located in one of the two iliac fossa (P = 0.02) and located outside these areas in only 11% of cases. The sensitivity and the specificity of this pain location to differentiate hyper from normosensitive patients were 0.89 and 0.59, respectively.
Conclusions & Inferences
The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.
The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity. The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.</description><identifier>ISSN: 1350-1925</identifier><identifier>EISSN: 1365-2982</identifier><identifier>DOI: 10.1111/nmo.13290</identifier><identifier>PMID: 29345401</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Abdomen ; abdominal pain ; clinical practice ; Human health and pathology ; Hypersensitivity ; Hépatology and Gastroenterology ; Intestine ; Irritable bowel syndrome ; Life Sciences ; Pain ; Pain perception ; pathophysiology ; Phenotypes ; Rectum ; Threshold limits ; visceral hypersensitivity</subject><ispartof>Neurogastroenterology and motility, 2018-06, Vol.30 (6), p.e13290-n/a</ispartof><rights>2018 John Wiley & Sons Ltd</rights><rights>2018 John Wiley & Sons Ltd.</rights><rights>Copyright © 2018 John Wiley & Sons Ltd</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3870-841e0347b14b8d7d9685935c5610c7e12a81263c782f82f2dcd993a2f02fcca93</citedby><cites>FETCH-LOGICAL-c3870-841e0347b14b8d7d9685935c5610c7e12a81263c782f82f2dcd993a2f02fcca93</cites><orcidid>0000-0001-8220-9155 ; 0000-0002-8146-1540 ; 0000-0002-6266-4203</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnmo.13290$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnmo.13290$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,780,784,885,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29345401$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-02332153$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Melchior, C.</creatorcontrib><creatorcontrib>Bril, L.</creatorcontrib><creatorcontrib>Leroi, A‐M.</creatorcontrib><creatorcontrib>Gourcerol, G.</creatorcontrib><creatorcontrib>Ducrotté, P.</creatorcontrib><title>Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study</title><title>Neurogastroenterology and motility</title><addtitle>Neurogastroenterol Motil</addtitle><description>Background
Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity.
Methods
This prospective study included consecutive IBS patients selected by Rome III criteria. Validated scores (IBS‐SSS, Bristol stool scale, HADS) were used to phenotype patients who were also asked to describe the main location of their abdominal pain on a simple image (abdomen divided into 6 zones). Progressive isobaric rectal distensions were performed to demonstrate, with the ascending method of limits, allodynia (pain threshold lower than 24 mmHg).
Key Results
Fifty patients (women: 72%), 42.6 ± 15.7 years old, were included. Sub‐types were IBS‐D, IBS‐C and IBS‐M in 58%, 22% and 20% of cases, respectively. Allodynia was present in 18% of cases. Neither IBS‐SSS nor intensity of pain was predictive of hypersensitivity. In hypersensitive patients, pain was more often located in one of the two iliac fossa (P = 0.02) and located outside these areas in only 11% of cases. The sensitivity and the specificity of this pain location to differentiate hyper from normosensitive patients were 0.89 and 0.59, respectively.
Conclusions & Inferences
The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.
The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity. The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.</description><subject>Abdomen</subject><subject>abdominal pain</subject><subject>clinical practice</subject><subject>Human health and pathology</subject><subject>Hypersensitivity</subject><subject>Hépatology and Gastroenterology</subject><subject>Intestine</subject><subject>Irritable bowel syndrome</subject><subject>Life Sciences</subject><subject>Pain</subject><subject>Pain perception</subject><subject>pathophysiology</subject><subject>Phenotypes</subject><subject>Rectum</subject><subject>Threshold limits</subject><subject>visceral hypersensitivity</subject><issn>1350-1925</issn><issn>1365-2982</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp1kd-K1TAQxoso7rp64QtIwBu96G7-NW2u5LCoKxxdEL0OaTqlWdKmJuk59GF8V3PsuoJgCGRIfvPNTL6ieEnwJcnrahr9JWFU4kfFOWGiKqls6ONTXOGSSFqdFc9ivMMYC8rF0-KMSsYrjsl58XMXAJlBB20SBBuTNRH5Hum286OdtEOzthMawM394lDyyHYwJduv-SHZHEZ0tGlABxsNhMwP6wwhwhRtsgebVpTTbQg26dYBav0RHIrr1AU_wjv0FeLi0lYSzcHHGUzOAxTT0q3Piye9dhFe3J8XxfcP779d35T724-frnf70rCmxmXDCWDG65bwtunqToqmkqwylSDY1ECobggVzNQN7fOmnemkZJr2mPbGaMkuireb7qCdmoMddViV11bd7PbqdIcpY5RU7EAy-2Zjc7c_FohJjafRndMT-CUqIhtZSS44zujrf9A7v4T8qVFRzGvOhcD4b3GTx48B-ocOCFYnf1X2V_32N7Ov7hWXdoTugfxjaAauNuBoHaz_V1JfPt9ukr8A-DGxCg</recordid><startdate>201806</startdate><enddate>201806</enddate><creator>Melchior, C.</creator><creator>Bril, L.</creator><creator>Leroi, A‐M.</creator><creator>Gourcerol, G.</creator><creator>Ducrotté, P.</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8220-9155</orcidid><orcidid>https://orcid.org/0000-0002-8146-1540</orcidid><orcidid>https://orcid.org/0000-0002-6266-4203</orcidid></search><sort><creationdate>201806</creationdate><title>Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study</title><author>Melchior, C. ; Bril, L. ; Leroi, A‐M. ; Gourcerol, G. ; Ducrotté, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3870-841e0347b14b8d7d9685935c5610c7e12a81263c782f82f2dcd993a2f02fcca93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abdomen</topic><topic>abdominal pain</topic><topic>clinical practice</topic><topic>Human health and pathology</topic><topic>Hypersensitivity</topic><topic>Hépatology and Gastroenterology</topic><topic>Intestine</topic><topic>Irritable bowel syndrome</topic><topic>Life Sciences</topic><topic>Pain</topic><topic>Pain perception</topic><topic>pathophysiology</topic><topic>Phenotypes</topic><topic>Rectum</topic><topic>Threshold limits</topic><topic>visceral hypersensitivity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Melchior, C.</creatorcontrib><creatorcontrib>Bril, L.</creatorcontrib><creatorcontrib>Leroi, A‐M.</creatorcontrib><creatorcontrib>Gourcerol, G.</creatorcontrib><creatorcontrib>Ducrotté, P.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neurogastroenterology and motility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Melchior, C.</au><au>Bril, L.</au><au>Leroi, A‐M.</au><au>Gourcerol, G.</au><au>Ducrotté, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study</atitle><jtitle>Neurogastroenterology and motility</jtitle><addtitle>Neurogastroenterol Motil</addtitle><date>2018-06</date><risdate>2018</risdate><volume>30</volume><issue>6</issue><spage>e13290</spage><epage>n/a</epage><pages>e13290-n/a</pages><issn>1350-1925</issn><eissn>1365-2982</eissn><abstract>Background
Some consider that patients with visceral hypersensitivity may represent a separate entity within the IBS population not only from a pathophysiological but also from a clinical perspective. The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity.
Methods
This prospective study included consecutive IBS patients selected by Rome III criteria. Validated scores (IBS‐SSS, Bristol stool scale, HADS) were used to phenotype patients who were also asked to describe the main location of their abdominal pain on a simple image (abdomen divided into 6 zones). Progressive isobaric rectal distensions were performed to demonstrate, with the ascending method of limits, allodynia (pain threshold lower than 24 mmHg).
Key Results
Fifty patients (women: 72%), 42.6 ± 15.7 years old, were included. Sub‐types were IBS‐D, IBS‐C and IBS‐M in 58%, 22% and 20% of cases, respectively. Allodynia was present in 18% of cases. Neither IBS‐SSS nor intensity of pain was predictive of hypersensitivity. In hypersensitive patients, pain was more often located in one of the two iliac fossa (P = 0.02) and located outside these areas in only 11% of cases. The sensitivity and the specificity of this pain location to differentiate hyper from normosensitive patients were 0.89 and 0.59, respectively.
Conclusions & Inferences
The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.
The aim of this prospective exploratory study was to assess whether characteristics of abdominal pain in IBS patients could be suggestive of hypersensitivity. The location of pain is different between hyper and normosensitive IBS patients. Pain located outside one of the two iliac fossa suggests that the patient is normosensitive.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>29345401</pmid><doi>10.1111/nmo.13290</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-8220-9155</orcidid><orcidid>https://orcid.org/0000-0002-8146-1540</orcidid><orcidid>https://orcid.org/0000-0002-6266-4203</orcidid></addata></record> |
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| subjects | Abdomen abdominal pain clinical practice Human health and pathology Hypersensitivity Hépatology and Gastroenterology Intestine Irritable bowel syndrome Life Sciences Pain Pain perception pathophysiology Phenotypes Rectum Threshold limits visceral hypersensitivity |
| title | Are characteristics of abdominal pain helpful to identify patients with visceral hypersensitivity in irritable bowel syndrome? Results of a prospective study |
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