Alteration of NMDA receptor-mediated synaptic responses in CA1 area of the aged rat hippocampus: Contribution of GABAergic and cholinergic deficits

Synaptic responses mediated by the N‐methyl‐D‐aspartate receptor (NMDAr) and non‐NMDAr activation were compared in CA1 hippocampal region of young (3–4 months old) and aged (25–33 months old) Sprague‐Dawley rats with the use of ex vivo extracellular recordings techniques. In aged rats, the amplitude...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Hippocampus 1998, Vol.8 (6), p.627-637
Hauptverfasser:	Jouvenceau, A., Dutar, P., Billard, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - physiology aging Aging - physiology Animals Antibodies, Monoclonal - toxicity CA1 pyramidal cells CGP 55845 Cholinergic Agents - toxicity cholinergic deafferentation compensatory mechanisms Denervation Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology GABA-B Receptor Antagonists GABAB receptor gamma-Aminobutyric Acid - physiology glutamate receptors hippocampus Hippocampus - drug effects Hippocampus - growth & development Hippocampus - physiology Immunotoxins - toxicity Life Sciences Male N-Glycosyl Hydrolases Nerve Fibers - drug effects Nerve Fibers - physiology Neurons and Cognition NMDA receptor Phosphinic Acids - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Propanolamines - pharmacology rat Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - physiology Ribosome Inactivating Proteins, Type 1 saporin Saporins Synapses - drug effects Synapses - physiology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!