Rho GTPases in osteoclasts: Orchestrators of podosome arrangement

Cells from the myeloid lineage, namely macrophages, dendritic cells and osteoclasts, develop podosomes instead of stress fibers and focal adhesions to adhere and migrate. Podosomes share many components with focal adhesions but differ in their molecular organization, with a dense core of polymerized...

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Veröffentlicht in:	European journal of cell biology 2008-09, Vol.87 (8), p.469-477
Hauptverfasser:	Ory, Stéphane, Brazier, Hélène, Pawlak, Géraldine, Blangy, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - chemistry Actin Cytoskeleton - ultrastructure Animals Biochemistry, Molecular Biology Cell Adhesion Cellular Biology Humans Life Sciences Models, Biological Osteoclast Osteoclasts - metabolism Osteoclasts - ultrastructure Podosome rac1 GTP-Binding Protein - metabolism rho GTP-Binding Proteins - metabolism Rho GTPases rhoA GTP-Binding Protein - metabolism RhoU Sealing zone Signal Transduction WASP Wrch-1
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