The gene expression profile of inflammatory, hypoxic and metabolic genes predicts the metastatic spread of human head and neck squamous cell carcinoma

Summary Objectives To assess the prognostic value of the expression profile of the main genes implicated in hypoxia, glucose and lactate metabolism, inflammation, angiogenesis and extracellular matrix interactions for the metastatic spread of head and neck squamous cell carcinoma. Patients and metho...

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Veröffentlicht in:	Oral oncology 2014-03, Vol.50 (3), p.200-207
Hauptverfasser:	Clatot, Florian, Gouérant, Sophie, Mareschal, Sylvain, Cornic, Marie, Berghian, Anca, Choussy, Olivier, El Ouakif, Faissal, François, Arnaud, Bénard, Magalie, Ruminy, Philippe, Picquenot, Jean-Michel, Jardin, Fabrice
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biochemistry, Molecular Biology Biological and medical sciences Blood Glucose - genetics Blood Glucose - metabolism Cancer Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - secondary Clustering analysis CXCL12 CXCR4 Extracellular Matrix - genetics Female Gene Expression Profiling Genomics Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and neck squamous cell carcinoma Hematology, Oncology and Palliative Medicine Humans Hypoxia - genetics Lactic Acid - metabolism Life Sciences Lymphatic Metastasis - genetics Male Medical sciences Metastasis Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Neoplasm Recurrence, Local - genetics Oral cancer Otolaryngology Otorhinolaryngology (head neck, general aspects and miscellaneous) Otorhinolaryngology. Stomatology Polymerase Chain Reaction Prognosis RNA - genetics Survival Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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