Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient
Nontuberculous mycobacteria (NTM) infection is a challenging diagnosis for clinicians in solid organ transplantation. Immune reconstitution inflammatory syndrome (IRIS) is so far unreported in this context. We report here the case of a renal transplant recipient who developed Mycobacterium kansasii–...
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| Veröffentlicht in: | American journal of transplantation 2015-12, Vol.15 (12), p.3255-3258 |
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| container_issue | 12 |
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| container_title | American journal of transplantation |
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| creator | Lemoine, M. Laurent, C. Hanoy, M. Leporrier, J. François, A. Guerrot, D. Godin, M. Bertrand, D. |
| description | Nontuberculous mycobacteria (NTM) infection is a challenging diagnosis for clinicians in solid organ transplantation. Immune reconstitution inflammatory syndrome (IRIS) is so far unreported in this context. We report here the case of a renal transplant recipient who developed Mycobacterium kansasii–associated lymphadenitis complicated by IRIS while undergoing reduction of his immunosuppressive therapy. For IRIS, the patient required low‐dose steroids and an increase in global immunosuppression, in association with NTM antibiotherapy.
The authors report an original case of immune reconstitution inflammatory syndrome secondary to Mycobacterium kansasii lymphadenitis in a kidney transplant patient, highlighting the importance of its recognition to manage an immunosuppression regimen. |
| doi_str_mv | 10.1111/ajt.13433 |
| format | Article |
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The authors report an original case of immune reconstitution inflammatory syndrome secondary to Mycobacterium kansasii lymphadenitis in a kidney transplant patient, highlighting the importance of its recognition to manage an immunosuppression regimen.</description><identifier>ISSN: 1600-6135</identifier><identifier>EISSN: 1600-6143</identifier><identifier>DOI: 10.1111/ajt.13433</identifier><identifier>PMID: 26372924</identifier><language>eng</language><publisher>United States: Elsevier Limited</publisher><subject>Adult ; antibiotic: antibacterial ; clinical research / practice ; complication: infectious ; Glomerular Filtration Rate ; Graft Survival ; Human health and pathology ; Humans ; Immune Reconstitution Inflammatory Syndrome - diagnosis ; Immune Reconstitution Inflammatory Syndrome - etiology ; immunosuppressive regimens ; infection ; infectious disease ; kidney (allograft) function / dysfunction ; Kidney Failure, Chronic - microbiology ; Kidney Failure, Chronic - surgery ; Kidney Function Tests ; Kidney Transplantation - adverse effects ; kidney transplantation / nephrology ; Life Sciences ; Male ; mycobacterial: nontuberculous ; Mycobacterium Infections, Nontuberculous - complications ; Mycobacterium Infections, Nontuberculous - microbiology ; Mycobacterium kansasii - pathogenicity ; Postoperative Complications ; Prognosis ; Risk Factors ; Transplant Recipients ; Transplants & implants ; Xenotransplantation</subject><ispartof>American journal of transplantation, 2015-12, Vol.15 (12), p.3255-3258</ispartof><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons</rights><rights>Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5583-442ee4e1c28ac9b5ca8584589603809f4eb7a83c8bad63ca6192bc9706e3ba2d3</citedby><cites>FETCH-LOGICAL-c5583-442ee4e1c28ac9b5ca8584589603809f4eb7a83c8bad63ca6192bc9706e3ba2d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajt.13433$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajt.13433$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26372924$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://normandie-univ.hal.science/hal-02317914$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lemoine, M.</creatorcontrib><creatorcontrib>Laurent, C.</creatorcontrib><creatorcontrib>Hanoy, M.</creatorcontrib><creatorcontrib>Leporrier, J.</creatorcontrib><creatorcontrib>François, A.</creatorcontrib><creatorcontrib>Guerrot, D.</creatorcontrib><creatorcontrib>Godin, M.</creatorcontrib><creatorcontrib>Bertrand, D.</creatorcontrib><title>Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient</title><title>American journal of transplantation</title><addtitle>Am J Transplant</addtitle><description>Nontuberculous mycobacteria (NTM) infection is a challenging diagnosis for clinicians in solid organ transplantation. Immune reconstitution inflammatory syndrome (IRIS) is so far unreported in this context. We report here the case of a renal transplant recipient who developed Mycobacterium kansasii–associated lymphadenitis complicated by IRIS while undergoing reduction of his immunosuppressive therapy. For IRIS, the patient required low‐dose steroids and an increase in global immunosuppression, in association with NTM antibiotherapy.
The authors report an original case of immune reconstitution inflammatory syndrome secondary to Mycobacterium kansasii lymphadenitis in a kidney transplant patient, highlighting the importance of its recognition to manage an immunosuppression regimen.</description><subject>Adult</subject><subject>antibiotic: antibacterial</subject><subject>clinical research / practice</subject><subject>complication: infectious</subject><subject>Glomerular Filtration Rate</subject><subject>Graft Survival</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Immune Reconstitution Inflammatory Syndrome - diagnosis</subject><subject>Immune Reconstitution Inflammatory Syndrome - etiology</subject><subject>immunosuppressive regimens</subject><subject>infection</subject><subject>infectious disease</subject><subject>kidney (allograft) function / dysfunction</subject><subject>Kidney Failure, Chronic - microbiology</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Function Tests</subject><subject>Kidney Transplantation - adverse effects</subject><subject>kidney transplantation / nephrology</subject><subject>Life Sciences</subject><subject>Male</subject><subject>mycobacterial: nontuberculous</subject><subject>Mycobacterium Infections, Nontuberculous - complications</subject><subject>Mycobacterium Infections, Nontuberculous - microbiology</subject><subject>Mycobacterium kansasii - pathogenicity</subject><subject>Postoperative Complications</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Transplant Recipients</subject><subject>Transplants & implants</subject><subject>Xenotransplantation</subject><issn>1600-6135</issn><issn>1600-6143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctuEzEUhi0EoiWw4AWQJTawSOvbzHiWUUVpIAiJhrXl8ZwIh7EdbA9o-vR4mhIkJLyxdfyd_1x-hF5SckHLudT7fEG54PwROqc1IcuaCv749ObVGXqW0p4Q2jDJnqIzVvOGtUyco7u1c6MH_AVM8CnbPGYbPF773aCd0znECd9Ovo_BAb6doV6XUA7402RCp02GaEeHv2ufdLJ2zgRzr2E91vij7T1MeBvL_2HQPs-V7MGCz8_Rk50eErx4uBfo6_W77dXNcvP5_fpqtVmaqpJ8KQQDEEANk9q0XWW0rKSoZFsTLkm7E9A1WnIjO93X3OiatqwzbUNq4J1mPV-gt0fdb3pQh2hdGUAFbdXNaqPmGGGcNi0VP2lh3xzZQww_RkhZOZsMDKVzCGNStOEVZw0tC1yg1_-g-zBGXyaZKSErUdXsb3ETQ0oRdqcOKFGzeaqYp-7NK-yrB8Wxc9CfyD9uFeDyCPyyA0z_V1KrD9uj5G-P_aPc</recordid><startdate>201512</startdate><enddate>201512</enddate><creator>Lemoine, M.</creator><creator>Laurent, C.</creator><creator>Hanoy, M.</creator><creator>Leporrier, J.</creator><creator>François, A.</creator><creator>Guerrot, D.</creator><creator>Godin, M.</creator><creator>Bertrand, D.</creator><general>Elsevier Limited</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>201512</creationdate><title>Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient</title><author>Lemoine, M. ; Laurent, C. ; Hanoy, M. ; Leporrier, J. ; François, A. ; Guerrot, D. ; Godin, M. ; Bertrand, D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5583-442ee4e1c28ac9b5ca8584589603809f4eb7a83c8bad63ca6192bc9706e3ba2d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>antibiotic: antibacterial</topic><topic>clinical research / practice</topic><topic>complication: infectious</topic><topic>Glomerular Filtration Rate</topic><topic>Graft Survival</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Immune Reconstitution Inflammatory Syndrome - diagnosis</topic><topic>Immune Reconstitution Inflammatory Syndrome - etiology</topic><topic>immunosuppressive regimens</topic><topic>infection</topic><topic>infectious disease</topic><topic>kidney (allograft) function / dysfunction</topic><topic>Kidney Failure, Chronic - microbiology</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Function Tests</topic><topic>Kidney Transplantation - adverse effects</topic><topic>kidney transplantation / nephrology</topic><topic>Life Sciences</topic><topic>Male</topic><topic>mycobacterial: nontuberculous</topic><topic>Mycobacterium Infections, Nontuberculous - complications</topic><topic>Mycobacterium Infections, Nontuberculous - microbiology</topic><topic>Mycobacterium kansasii - pathogenicity</topic><topic>Postoperative Complications</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Transplant Recipients</topic><topic>Transplants & implants</topic><topic>Xenotransplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lemoine, M.</creatorcontrib><creatorcontrib>Laurent, C.</creatorcontrib><creatorcontrib>Hanoy, M.</creatorcontrib><creatorcontrib>Leporrier, J.</creatorcontrib><creatorcontrib>François, A.</creatorcontrib><creatorcontrib>Guerrot, D.</creatorcontrib><creatorcontrib>Godin, M.</creatorcontrib><creatorcontrib>Bertrand, D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>American journal of transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lemoine, M.</au><au>Laurent, C.</au><au>Hanoy, M.</au><au>Leporrier, J.</au><au>François, A.</au><au>Guerrot, D.</au><au>Godin, M.</au><au>Bertrand, D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient</atitle><jtitle>American journal of transplantation</jtitle><addtitle>Am J Transplant</addtitle><date>2015-12</date><risdate>2015</risdate><volume>15</volume><issue>12</issue><spage>3255</spage><epage>3258</epage><pages>3255-3258</pages><issn>1600-6135</issn><eissn>1600-6143</eissn><abstract>Nontuberculous mycobacteria (NTM) infection is a challenging diagnosis for clinicians in solid organ transplantation. 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| subjects | Adult antibiotic: antibacterial clinical research / practice complication: infectious Glomerular Filtration Rate Graft Survival Human health and pathology Humans Immune Reconstitution Inflammatory Syndrome - diagnosis Immune Reconstitution Inflammatory Syndrome - etiology immunosuppressive regimens infection infectious disease kidney (allograft) function / dysfunction Kidney Failure, Chronic - microbiology Kidney Failure, Chronic - surgery Kidney Function Tests Kidney Transplantation - adverse effects kidney transplantation / nephrology Life Sciences Male mycobacterial: nontuberculous Mycobacterium Infections, Nontuberculous - complications Mycobacterium Infections, Nontuberculous - microbiology Mycobacterium kansasii - pathogenicity Postoperative Complications Prognosis Risk Factors Transplant Recipients Transplants & implants Xenotransplantation |
| title | Immune Reconstitution Inflammatory Syndrome Secondary to Mycobacterium kansasii Infection in a Kidney Transplant Recipient |
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