The opioid system and the social brain: implications for depression and suicide
In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has mor...
Gespeichert in:
| Veröffentlicht in: | Journal of neuroscience research 2020-04, Vol.98 (4), p.588-600 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 600 |
|---|---|
| container_issue | 4 |
| container_start_page | 588 |
| container_title | Journal of neuroscience research |
| container_volume | 98 |
| creator | Lutz, Pierre‐Eric Courtet, Philippe Calati, Raffaella |
| description | In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid‐dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities. |
| doi_str_mv | 10.1002/jnr.24269 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02317670v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2352950691</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4229-fd269cf4fc40e163ac0a768c13bfc64f4f812282ce006e8882b02f40a90ed4c23</originalsourceid><addsrcrecordid>eNp1kU1LxDAQhoMouq4e_ANS8KKHupM0bRNvi_jJ4oLoOaRpilnapiatsv_e7K6uIHgaZuaZd2Z4ETrBcIkByGTRuktCScZ30AgDz2Oa0nwXjSDJIKaAyQE69H4BAJynyT46SABSTBkbofnLm45sZ6wpI7_0vW4i2ZZRH6reKiPrqHDStFeRabraKNkb2_qosi4qdee09yFfT_jBKFPqI7RXydrr4-84Rq-3Ny_X9_FsfvdwPZ3FihLC46oM16qKVoqCxlkiFcg8YwonRaUyGhoME8KI0gCZZoyRAkhFQXLQJVUkGaOLje6brEXnTCPdUlhpxP10JlY1IAnOsxw-cGDPN2zn7PugfS8a45Wua9lqO3hBIGdpWMFZQM_-oAs7uDZ8IkiSEp5CxvHvcuWs905X2wswiJUjIjgi1o4E9vRbcSgaXW7JHwsCMNkAn6bWy_-VxOPT80byCzUEkxA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2352950691</pqid></control><display><type>article</type><title>The opioid system and the social brain: implications for depression and suicide</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Lutz, Pierre‐Eric ; Courtet, Philippe ; Calati, Raffaella</creator><creatorcontrib>Lutz, Pierre‐Eric ; Courtet, Philippe ; Calati, Raffaella</creatorcontrib><description>In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid‐dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.</description><identifier>ISSN: 0360-4012</identifier><identifier>EISSN: 1097-4547</identifier><identifier>DOI: 10.1002/jnr.24269</identifier><identifier>PMID: 30051488</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>depression ; Human health and pathology ; Life Sciences ; Medical innovations ; Narcotics ; Neurons and Cognition ; Opioid system ; Opioids ; Pain ; Psychiatrics and mental health ; Reinforcement ; Social behavior ; Social factors ; Social interactions ; social pain ; social reward ; Suicide</subject><ispartof>Journal of neuroscience research, 2020-04, Vol.98 (4), p.588-600</ispartof><rights>2018 Wiley Periodicals, Inc.</rights><rights>2020 Wiley Periodicals, Inc.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4229-fd269cf4fc40e163ac0a768c13bfc64f4f812282ce006e8882b02f40a90ed4c23</citedby><cites>FETCH-LOGICAL-c4229-fd269cf4fc40e163ac0a768c13bfc64f4f812282ce006e8882b02f40a90ed4c23</cites><orcidid>0000-0001-8130-437X ; 0000-0003-3383-1604 ; 0000-0002-6519-8586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjnr.24269$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjnr.24269$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30051488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.umontpellier.fr/hal-02317670$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Lutz, Pierre‐Eric</creatorcontrib><creatorcontrib>Courtet, Philippe</creatorcontrib><creatorcontrib>Calati, Raffaella</creatorcontrib><title>The opioid system and the social brain: implications for depression and suicide</title><title>Journal of neuroscience research</title><addtitle>J Neurosci Res</addtitle><description>In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid‐dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.</description><subject>depression</subject><subject>Human health and pathology</subject><subject>Life Sciences</subject><subject>Medical innovations</subject><subject>Narcotics</subject><subject>Neurons and Cognition</subject><subject>Opioid system</subject><subject>Opioids</subject><subject>Pain</subject><subject>Psychiatrics and mental health</subject><subject>Reinforcement</subject><subject>Social behavior</subject><subject>Social factors</subject><subject>Social interactions</subject><subject>social pain</subject><subject>social reward</subject><subject>Suicide</subject><issn>0360-4012</issn><issn>1097-4547</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kU1LxDAQhoMouq4e_ANS8KKHupM0bRNvi_jJ4oLoOaRpilnapiatsv_e7K6uIHgaZuaZd2Z4ETrBcIkByGTRuktCScZ30AgDz2Oa0nwXjSDJIKaAyQE69H4BAJynyT46SABSTBkbofnLm45sZ6wpI7_0vW4i2ZZRH6reKiPrqHDStFeRabraKNkb2_qosi4qdee09yFfT_jBKFPqI7RXydrr4-84Rq-3Ny_X9_FsfvdwPZ3FihLC46oM16qKVoqCxlkiFcg8YwonRaUyGhoME8KI0gCZZoyRAkhFQXLQJVUkGaOLje6brEXnTCPdUlhpxP10JlY1IAnOsxw-cGDPN2zn7PugfS8a45Wua9lqO3hBIGdpWMFZQM_-oAs7uDZ8IkiSEp5CxvHvcuWs905X2wswiJUjIjgi1o4E9vRbcSgaXW7JHwsCMNkAn6bWy_-VxOPT80byCzUEkxA</recordid><startdate>202004</startdate><enddate>202004</enddate><creator>Lutz, Pierre‐Eric</creator><creator>Courtet, Philippe</creator><creator>Calati, Raffaella</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-8130-437X</orcidid><orcidid>https://orcid.org/0000-0003-3383-1604</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid></search><sort><creationdate>202004</creationdate><title>The opioid system and the social brain: implications for depression and suicide</title><author>Lutz, Pierre‐Eric ; Courtet, Philippe ; Calati, Raffaella</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4229-fd269cf4fc40e163ac0a768c13bfc64f4f812282ce006e8882b02f40a90ed4c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>depression</topic><topic>Human health and pathology</topic><topic>Life Sciences</topic><topic>Medical innovations</topic><topic>Narcotics</topic><topic>Neurons and Cognition</topic><topic>Opioid system</topic><topic>Opioids</topic><topic>Pain</topic><topic>Psychiatrics and mental health</topic><topic>Reinforcement</topic><topic>Social behavior</topic><topic>Social factors</topic><topic>Social interactions</topic><topic>social pain</topic><topic>social reward</topic><topic>Suicide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lutz, Pierre‐Eric</creatorcontrib><creatorcontrib>Courtet, Philippe</creatorcontrib><creatorcontrib>Calati, Raffaella</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Journal of neuroscience research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lutz, Pierre‐Eric</au><au>Courtet, Philippe</au><au>Calati, Raffaella</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The opioid system and the social brain: implications for depression and suicide</atitle><jtitle>Journal of neuroscience research</jtitle><addtitle>J Neurosci Res</addtitle><date>2020-04</date><risdate>2020</risdate><volume>98</volume><issue>4</issue><spage>588</spage><epage>600</epage><pages>588-600</pages><issn>0360-4012</issn><eissn>1097-4547</eissn><abstract>In the past decade, considerable attention has been drawn to social interactions and behaviors as sources of pleasurable (social reward) and painful (social pain) emotional states. While the role of the opioid system in the regulation of reward and pain processes has long been recognized, it has more recently been investigated and characterized in the specific context of social experiences across several mammalian species. Accordingly, the present narrative review provides a comprehensive summary of studies detailing how the opioid system controls social reward and social pain. From a translational and pathophysiological perspective, we further discuss how opioid‐dependent regulation of social behaviors may contribute to depressive illness and suicidal behaviors, and ultimately provide innovative therapeutic opportunities.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30051488</pmid><doi>10.1002/jnr.24269</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0001-8130-437X</orcidid><orcidid>https://orcid.org/0000-0003-3383-1604</orcidid><orcidid>https://orcid.org/0000-0002-6519-8586</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0360-4012 |
| ispartof | Journal of neuroscience research, 2020-04, Vol.98 (4), p.588-600 |
| issn | 0360-4012 1097-4547 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02317670v1 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | depression Human health and pathology Life Sciences Medical innovations Narcotics Neurons and Cognition Opioid system Opioids Pain Psychiatrics and mental health Reinforcement Social behavior Social factors Social interactions social pain social reward Suicide |
| title | The opioid system and the social brain: implications for depression and suicide |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T04%3A14%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20opioid%20system%20and%20the%20social%20brain:%20implications%20for%20depression%20and%20suicide&rft.jtitle=Journal%20of%20neuroscience%20research&rft.au=Lutz,%20Pierre%E2%80%90Eric&rft.date=2020-04&rft.volume=98&rft.issue=4&rft.spage=588&rft.epage=600&rft.pages=588-600&rft.issn=0360-4012&rft.eissn=1097-4547&rft_id=info:doi/10.1002/jnr.24269&rft_dat=%3Cproquest_hal_p%3E2352950691%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2352950691&rft_id=info:pmid/30051488&rfr_iscdi=true |