N‑Terminal Liver-Expressed Antimicrobial Peptide 2 (LEAP2) Region Exhibits Inverse Agonist Activity toward the Ghrelin Receptor

The ghrelin receptor or growth hormone secretagogue receptor (GHSR) is a G-protein-coupled receptor that controls growth hormone and insulin secretion, food intake, and reward-seeking behaviors. Liver-expressed antimicrobial peptide 2 (LEAP2) was recently described as an endogenous antagonist of GHS...

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Veröffentlicht in:	Journal of medicinal chemistry 2019-01, Vol.62 (2), p.965-973
Hauptverfasser:	M’Kadmi, Céline, Cabral, Agustina, Barrile, Franco, Giribaldi, Julien, Cantel, Sonia, Damian, Marjorie, Mary, Sophie, Denoyelle, Séverine, Dutertre, Sébastien, Péraldi-Roux, Sylvie, Neasta, Jérémie, Oiry, Catherine, Banères, Jean-Louis, Marie, Jacky, Perello, Mario, Fehrentz, Jean-Alain
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemical Sciences Medicinal Chemistry
Online-Zugang:	Volltext
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