Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom

The glycopeptide CcTx, isolated from the venom of the piscivorous cone snail Conus consors, belongs to the κA‐family of conopeptides. These toxins elicit excitotoxic responses in the prey by acting on voltage‐gated sodium channels. The structure of CcTx, a first in the κA‐family, has been determined...

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Veröffentlicht in:	Chemistry : a European journal 2013-01, Vol.19 (3), p.870-879
Hauptverfasser:	Hocking, Henry G., Gerwig, Gerrit J., Dutertre, Sébastien, Violette, Aude, Favreau, Philipe, Stöcklin, Reto, Kamerling, Johannis P., Boelens, Rolf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry, Molecular Biology Channels Chemical Sciences Chemistry conformation analysis Conus Snail - chemistry Glycopeptides Glycopeptides - chemistry Glycosylation Life Sciences Magnetic Resonance Spectroscopy Medicinal Chemistry Molecular Structure Mollusk Venoms - chemistry NMR spectroscopy Poisons Snails Sodium Structural Biology structure elucidation Terminals Toxicology Toxins venom
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