Uridylation Earmarks mRNAs for Degradation… and More
Groundbreaking discoveries have uncovered the widespread post-transcriptional modifications of all classes of RNA. These studies have led to the emerging notion of an ‘epitranscriptome’ as a new layer of gene regulation. Diverse modifications control RNA fate, including the 3′ addition of untemplate...
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Veröffentlicht in: | Trends in genetics 2016-10, Vol.32 (10), p.607-619 |
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description | Groundbreaking discoveries have uncovered the widespread post-transcriptional modifications of all classes of RNA. These studies have led to the emerging notion of an ‘epitranscriptome’ as a new layer of gene regulation. Diverse modifications control RNA fate, including the 3′ addition of untemplated nucleotides or 3′ tailing. The most exciting recent discoveries in 3′ tailing are related to uridylation. Uridylation targets various noncoding RNAs, from small RNAs and their precursors to rRNAs, and U tails mostly regulate processing or degradation. Interestingly, uridylation is also a pervasive modification of mRNAs. In this review, we discuss how the addition of few uridines to the 3′ end of mRNAs influences mRNA decay. We also consider recent findings that reveal other consequences of uridylation on mRNA fate. |
doi_str_mv | 10.1016/j.tig.2016.08.003 |
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We also consider recent findings that reveal other consequences of uridylation on mRNA fate.</description><subject>3' Untranslated Regions - genetics</subject><subject>deadenylation</subject><subject>degradation</subject><subject>Gene Expression Regulation - genetics</subject><subject>Humans</subject><subject>Life Sciences</subject><subject>Medical Education</subject><subject>mRNA</subject><subject>RNA Stability - genetics</subject><subject>RNA, Messenger - genetics</subject><subject>translation</subject><subject>Uridine - genetics</subject><subject>Uridine - metabolism</subject><subject>uridylation</subject><subject>Vegetal Biology</subject><issn>0168-9525</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkk1uFDEQhb0AJSFwADaol7CYTvmv7RYS0igEEmkACYjEzvK4y8GTnnZi90SaHafhYDlJ3JmQBQvEymXX955Kz0XISwo1BdocreoxXNSslDXoGoA_IQflometZHKfPMt5BQBScblH9pmSLRNUHpDmPIVu29sxxKE6sWlt02Wu1l8_z3PlY6re40Wy3X379tfvyg5d9SkmfE6eettnfPFwHpLzDyffj09niy8fz47ni5kTSo4zVEyLlnW8sQ1IyoTmmnvbLn3jG9dS4RmyljnmlpxxoJR5uRRUC69AKIv8kLzZ-f60vblKoYy3NdEGczpfmOkNioxpzW9oYV_v2KsUrzeYR7MO2WHf2wHjJhuqmWpZQ0H8DzrZKq4KSneoSzHnhP5xDApmSt6sTEneTMkb0KYkXzSvHuw3yzV2j4o_sRfg7Q7Akt1NwGSyCzg47EJCN5ouhn_av_tL7fowBGf7S9xiXsVNGsqnGGoyM2C-TWswbQFtOIDmP_gdi5ynjQ</recordid><startdate>20161001</startdate><enddate>20161001</enddate><creator>Scheer, Hélène</creator><creator>Zuber, Hélène</creator><creator>De Almeida, Caroline</creator><creator>Gagliardi, Dominique</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0002-2132-4536</orcidid><orcidid>https://orcid.org/0000-0002-5871-7544</orcidid></search><sort><creationdate>20161001</creationdate><title>Uridylation Earmarks mRNAs for Degradation… and More</title><author>Scheer, Hélène ; Zuber, Hélène ; De Almeida, Caroline ; Gagliardi, Dominique</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-e728492d36a6051248383fa9bf6f6c914f2e292c2cb3230112f5b4184f7047ae3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>3' Untranslated Regions - genetics</topic><topic>deadenylation</topic><topic>degradation</topic><topic>Gene Expression Regulation - genetics</topic><topic>Humans</topic><topic>Life Sciences</topic><topic>Medical Education</topic><topic>mRNA</topic><topic>RNA Stability - genetics</topic><topic>RNA, Messenger - genetics</topic><topic>translation</topic><topic>Uridine - genetics</topic><topic>Uridine - metabolism</topic><topic>uridylation</topic><topic>Vegetal Biology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scheer, Hélène</creatorcontrib><creatorcontrib>Zuber, Hélène</creatorcontrib><creatorcontrib>De Almeida, Caroline</creatorcontrib><creatorcontrib>Gagliardi, Dominique</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Trends in genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scheer, Hélène</au><au>Zuber, Hélène</au><au>De Almeida, Caroline</au><au>Gagliardi, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Uridylation Earmarks mRNAs for Degradation… and More</atitle><jtitle>Trends in genetics</jtitle><addtitle>Trends Genet</addtitle><date>2016-10-01</date><risdate>2016</risdate><volume>32</volume><issue>10</issue><spage>607</spage><epage>619</epage><pages>607-619</pages><issn>0168-9525</issn><abstract>Groundbreaking discoveries have uncovered the widespread post-transcriptional modifications of all classes of RNA. 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subjects | 3' Untranslated Regions - genetics deadenylation degradation Gene Expression Regulation - genetics Humans Life Sciences Medical Education mRNA RNA Stability - genetics RNA, Messenger - genetics translation Uridine - genetics Uridine - metabolism uridylation Vegetal Biology |
title | Uridylation Earmarks mRNAs for Degradation… and More |
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