Structure of the Mycobacterium tuberculosis OmpATb protein: A model of an oligomeric channel in the mycobacterial cell wall

The pore‐forming outer membrane protein OmpATb from Mycobacterium tuberculosis is a virulence factor required for acid resistance in host phagosomes. In this study, we determined the 3D structure of OmpATb by NMR in solution. We found that OmpATb is composed of two independent domains separated by a...

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Veröffentlicht in:	Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2011-02, Vol.79 (2), p.645-661
Hauptverfasser:	Yang, Yinshan, Auguin, Daniel, Delbecq, Stéphane, Dumas, Emilie, Molle, Gérard, Molle, Virginie, Roumestand, Christian, Saint, Nathalie
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - biosynthesis Bacterial Proteins - chemistry Bacteriology Cell Wall HADDOCK calculation Life Sciences Light membrane protein Microbiology and Parasitology Mycobacterium tuberculosis Mycobacterium tuberculosis - metabolism NMR structure Nuclear Magnetic Resonance, Biomolecular oligomeric assembly porin Porins - biosynthesis Porins - chemistry Protein Multimerization Protein Structure, Tertiary Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Scattering, Radiation Structural Homology, Protein Surface Properties
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