Role of RNA structures m c- myc and c- fos gene regulations
Proto-oncogenes c- myc and c- fos are subjected to a complex set of controls operating both at the transcriptional and post-transcriptional levels. We report here that: (i) antisense transcription occurs at the murine c- myc locus. However, its biological significance remains to be established; (ii)...
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| Veröffentlicht in: | Gene 1988-12, Vol.72 (1), p.287-295 |
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| container_issue | 1 |
| container_start_page | 287 |
| container_title | Gene |
| container_volume | 72 |
| creator | Piechaczyk, Marc Blanchard, Jean-Marie Bonnieu, Anne Fort, Philippe Mechti, Nadir Rech, Jocelyne Cuny, Marguerite Marty, Louise Ferré, François Lebleu, Bernard Jeanteur, Philippe |
| description | Proto-oncogenes c-
myc and c-
fos are subjected to a complex set of controls operating both at the transcriptional and post-transcriptional levels. We report here that: (i) antisense transcription occurs at the murine c-
myc locus. However, its biological significance remains to be established; (ii) transcription of both genes is regulated in various situations by a block to elongation of nascent RNA chains. In the case of c-
myc, the blockade involves a RNA structure whose nature remains unknown; (iii) elements responsible for the high degree of instability of c-
myc and c-
fos mRNAs reside in their 3' non-coding regions. A U-rich region, reminiscent of that present in the granulocyte-monocyte colony-stimulating factor mRNA destabilizer, is likely to be involved in the rapid degradation of c-
fos mRNA; (iv) exon 1 substitution by intron 1-derived sequences lessens or negates the effect of the 3' destabilizer in abnormal c-
myc RNAs from Burkitt's lymphomas and mouse plasmacytomas. |
| doi_str_mv | 10.1016/0378-1119(88)90154-0 |
| format | Article |
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myc and c-
fos are subjected to a complex set of controls operating both at the transcriptional and post-transcriptional levels. We report here that: (i) antisense transcription occurs at the murine c-
myc locus. However, its biological significance remains to be established; (ii) transcription of both genes is regulated in various situations by a block to elongation of nascent RNA chains. In the case of c-
myc, the blockade involves a RNA structure whose nature remains unknown; (iii) elements responsible for the high degree of instability of c-
myc and c-
fos mRNAs reside in their 3' non-coding regions. A U-rich region, reminiscent of that present in the granulocyte-monocyte colony-stimulating factor mRNA destabilizer, is likely to be involved in the rapid degradation of c-
fos mRNA; (iv) exon 1 substitution by intron 1-derived sequences lessens or negates the effect of the 3' destabilizer in abnormal c-
myc RNAs from Burkitt's lymphomas and mouse plasmacytomas.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/0378-1119(88)90154-0</identifier><language>eng</language><publisher>Elsevier B.V</publisher><subject>antisense RNA ; Biochemistry, Molecular Biology ; Biodiversity ; Cancer ; Cellular Biology ; Development Biology ; elongation block ; Embryology and Organogenesis ; exon ; intron ; Life Sciences ; Molecular biology ; mRNA instability ; oncogenes ; Recombinant DNA ; retrovirus ; Subcellular Processes ; Systematics, Phylogenetics and taxonomy ; transcription</subject><ispartof>Gene, 1988-12, Vol.72 (1), p.287-295</ispartof><rights>1988</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-c19fb4d8acb80114e07fee0a5cf63c804e7ed617c058869fac500484d8bfad3e3</citedby><cites>FETCH-LOGICAL-c253t-c19fb4d8acb80114e07fee0a5cf63c804e7ed617c058869fac500484d8bfad3e3</cites><orcidid>0000-0001-5997-8722 ; 0000-0003-3641-1939</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1119(88)90154-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,778,782,883,3539,27907,27908,45978</link.rule.ids><backlink>$$Uhttps://hal.science/hal-02267553$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Piechaczyk, Marc</creatorcontrib><creatorcontrib>Blanchard, Jean-Marie</creatorcontrib><creatorcontrib>Bonnieu, Anne</creatorcontrib><creatorcontrib>Fort, Philippe</creatorcontrib><creatorcontrib>Mechti, Nadir</creatorcontrib><creatorcontrib>Rech, Jocelyne</creatorcontrib><creatorcontrib>Cuny, Marguerite</creatorcontrib><creatorcontrib>Marty, Louise</creatorcontrib><creatorcontrib>Ferré, François</creatorcontrib><creatorcontrib>Lebleu, Bernard</creatorcontrib><creatorcontrib>Jeanteur, Philippe</creatorcontrib><title>Role of RNA structures m c- myc and c- fos gene regulations</title><title>Gene</title><description>Proto-oncogenes c-
myc and c-
fos are subjected to a complex set of controls operating both at the transcriptional and post-transcriptional levels. We report here that: (i) antisense transcription occurs at the murine c-
myc locus. However, its biological significance remains to be established; (ii) transcription of both genes is regulated in various situations by a block to elongation of nascent RNA chains. In the case of c-
myc, the blockade involves a RNA structure whose nature remains unknown; (iii) elements responsible for the high degree of instability of c-
myc and c-
fos mRNAs reside in their 3' non-coding regions. A U-rich region, reminiscent of that present in the granulocyte-monocyte colony-stimulating factor mRNA destabilizer, is likely to be involved in the rapid degradation of c-
fos mRNA; (iv) exon 1 substitution by intron 1-derived sequences lessens or negates the effect of the 3' destabilizer in abnormal c-
myc RNAs from Burkitt's lymphomas and mouse plasmacytomas.</description><subject>antisense RNA</subject><subject>Biochemistry, Molecular Biology</subject><subject>Biodiversity</subject><subject>Cancer</subject><subject>Cellular Biology</subject><subject>Development Biology</subject><subject>elongation block</subject><subject>Embryology and Organogenesis</subject><subject>exon</subject><subject>intron</subject><subject>Life Sciences</subject><subject>Molecular biology</subject><subject>mRNA instability</subject><subject>oncogenes</subject><subject>Recombinant DNA</subject><subject>retrovirus</subject><subject>Subcellular Processes</subject><subject>Systematics, Phylogenetics and taxonomy</subject><subject>transcription</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><recordid>eNp9kEFLAzEQhYMoWKv_wEOO9hCdbDa7WQShFLVCUSh6Dml2UiPbjSTbQv-9u1Z6dC4zPN57MB8h1xxuOfDiDkSpGOe8ulFqUgGXOYMTMuKqrBiAUKdkdLSck4uUvqAfKbMRuV-GBmlwdPk6pamLW9ttIya6oZbRzd5S09bD6UKia2yRRlxvG9P50KZLcuZMk_Dqb4_Jx9Pj-2zOFm_PL7PpgtlMio5ZXrlVXitjVwo4zxFKhwhGWlcIqyDHEuuClxakUkXljJUAueoTK2dqgWJMJofeT9Po7-g3Ju51MF7Ppws9aJBlRSml2PHemx-8NoaUIrpjgIMeYOmBhB5IaKX0L6xeGpOHQwz7P3Yeo07WY2ux9hFtp-vg_y_4AWApbpE</recordid><startdate>198812</startdate><enddate>198812</enddate><creator>Piechaczyk, Marc</creator><creator>Blanchard, Jean-Marie</creator><creator>Bonnieu, Anne</creator><creator>Fort, Philippe</creator><creator>Mechti, Nadir</creator><creator>Rech, Jocelyne</creator><creator>Cuny, Marguerite</creator><creator>Marty, Louise</creator><creator>Ferré, François</creator><creator>Lebleu, Bernard</creator><creator>Jeanteur, Philippe</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>AAYXX</scope><scope>CITATION</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5997-8722</orcidid><orcidid>https://orcid.org/0000-0003-3641-1939</orcidid></search><sort><creationdate>198812</creationdate><title>Role of RNA structures m c- myc and c- fos gene regulations</title><author>Piechaczyk, Marc ; Blanchard, Jean-Marie ; Bonnieu, Anne ; Fort, Philippe ; Mechti, Nadir ; Rech, Jocelyne ; Cuny, Marguerite ; Marty, Louise ; Ferré, François ; Lebleu, Bernard ; Jeanteur, Philippe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-c19fb4d8acb80114e07fee0a5cf63c804e7ed617c058869fac500484d8bfad3e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>antisense RNA</topic><topic>Biochemistry, Molecular Biology</topic><topic>Biodiversity</topic><topic>Cancer</topic><topic>Cellular Biology</topic><topic>Development Biology</topic><topic>elongation block</topic><topic>Embryology and Organogenesis</topic><topic>exon</topic><topic>intron</topic><topic>Life Sciences</topic><topic>Molecular biology</topic><topic>mRNA instability</topic><topic>oncogenes</topic><topic>Recombinant DNA</topic><topic>retrovirus</topic><topic>Subcellular Processes</topic><topic>Systematics, Phylogenetics and taxonomy</topic><topic>transcription</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Piechaczyk, Marc</creatorcontrib><creatorcontrib>Blanchard, Jean-Marie</creatorcontrib><creatorcontrib>Bonnieu, Anne</creatorcontrib><creatorcontrib>Fort, Philippe</creatorcontrib><creatorcontrib>Mechti, Nadir</creatorcontrib><creatorcontrib>Rech, Jocelyne</creatorcontrib><creatorcontrib>Cuny, Marguerite</creatorcontrib><creatorcontrib>Marty, Louise</creatorcontrib><creatorcontrib>Ferré, François</creatorcontrib><creatorcontrib>Lebleu, Bernard</creatorcontrib><creatorcontrib>Jeanteur, Philippe</creatorcontrib><collection>CrossRef</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Piechaczyk, Marc</au><au>Blanchard, Jean-Marie</au><au>Bonnieu, Anne</au><au>Fort, Philippe</au><au>Mechti, Nadir</au><au>Rech, Jocelyne</au><au>Cuny, Marguerite</au><au>Marty, Louise</au><au>Ferré, François</au><au>Lebleu, Bernard</au><au>Jeanteur, Philippe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of RNA structures m c- myc and c- fos gene regulations</atitle><jtitle>Gene</jtitle><date>1988-12</date><risdate>1988</risdate><volume>72</volume><issue>1</issue><spage>287</spage><epage>295</epage><pages>287-295</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Proto-oncogenes c-
myc and c-
fos are subjected to a complex set of controls operating both at the transcriptional and post-transcriptional levels. We report here that: (i) antisense transcription occurs at the murine c-
myc locus. However, its biological significance remains to be established; (ii) transcription of both genes is regulated in various situations by a block to elongation of nascent RNA chains. In the case of c-
myc, the blockade involves a RNA structure whose nature remains unknown; (iii) elements responsible for the high degree of instability of c-
myc and c-
fos mRNAs reside in their 3' non-coding regions. A U-rich region, reminiscent of that present in the granulocyte-monocyte colony-stimulating factor mRNA destabilizer, is likely to be involved in the rapid degradation of c-
fos mRNA; (iv) exon 1 substitution by intron 1-derived sequences lessens or negates the effect of the 3' destabilizer in abnormal c-
myc RNAs from Burkitt's lymphomas and mouse plasmacytomas.</abstract><pub>Elsevier B.V</pub><doi>10.1016/0378-1119(88)90154-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5997-8722</orcidid><orcidid>https://orcid.org/0000-0003-3641-1939</orcidid></addata></record> |
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| ispartof | Gene, 1988-12, Vol.72 (1), p.287-295 |
| issn | 0378-1119 1879-0038 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | antisense RNA Biochemistry, Molecular Biology Biodiversity Cancer Cellular Biology Development Biology elongation block Embryology and Organogenesis exon intron Life Sciences Molecular biology mRNA instability oncogenes Recombinant DNA retrovirus Subcellular Processes Systematics, Phylogenetics and taxonomy transcription |
| title | Role of RNA structures m c- myc and c- fos gene regulations |
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