Primary cilia control telencephalic patterning and morphogenesis via Gli3 proteolytic processing

Primary cilia have essential functions in vertebrate development and signaling. However, little is known about cilia function in brain morphogenesis, a process that is severely affected in human ciliopathies. Here, we study telencephalic morphogenesis in a mouse mutant for the ciliopathy gene Ftm (R...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Development (Cambridge) 2011-05, Vol.138 (10), p.2079-2088
Hauptverfasser:	Besse, Laurianne, Neti, Mariame, Anselme, Isabelle, Gerhardt, Christoph, Rüther, Ulrich, Laclef, Christine, Schneider-Maunoury, Sylvie
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animal genetics Animals Base Sequence Body Patterning Brain Cell Behavior Cell Differentiation Cellular Biology Cilia Cilia - physiology Development Development Biology DNA Primers - genetics Embryology and Organogenesis Female Fetuses Genetics Gestation Gli3 protein Humans Kruppel-Like Transcription Factors - genetics Kruppel-Like Transcription Factors - metabolism Life Sciences Mice Mice, Inbred C57BL Mice, Knockout Mice, Mutant Strains Microscopy, Electron, Scanning Morphogenesis Mutant Proteins - genetics Mutant Proteins - metabolism Mutation Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Olfactory bulb Olfactory Bulb - cytology Olfactory Bulb - embryology Olfactory Bulb - metabolism Pallium Pattern formation Pregnancy Protein Processing, Post-Translational Proteolysis Repressors Sensory Receptor Cells - cytology Telencephalon Telencephalon - cytology Telencephalon - embryology Telencephalon - metabolism Zinc Finger Protein Gli3
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!