Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence
Background Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow‐up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis. Methods We conducted a telephone survey of 166...
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| Veröffentlicht in: | Pediatric allergy and immunology 2019-05, Vol.30 (3), p.341-347 |
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| creator | Pouessel, Guillaume Cerbelle, Valentine Lejeune, Stephanie Leteurtre, Stephane Ramdane, Nassima Deschildre, Antoine Tourneux, P Boussicault, G Thiriez, G Brissaud, O Garenne, A Jokic, M Petit, I Semama, D Bergounioux, J Debillon, T Wroblewski, I Dorkenoo Morgan, RA Mallet, E Javouhey, E Vanel, B Vialet, R Michel, F Cambonie, G Milesi, C Boussard, N Joram, N Dupont, D Tissières, P Dauger, S Renolleau, S Leger, PL Mansir, T Saulnier, JP Bednarek, N Tirel, O Blanc, T Patural, H Astruc, D Marcoux, MO Amadieu, R Chantreuil, J |
| description | Background
Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow‐up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.
Methods
We conducted a telephone survey of 166 children (≤18 years) hospitalized from 2003 to 2013.
Results
In all, 106 (64%) completed the survey (boys, 59%; mean age [SD]: 15.3 years [5.5]). The main index triggers were drugs (45%) and foods (37%). The mean duration follow‐up was of 7.7 years (SD: 2.4). Thirty‐eight (36%) children experienced 399 new allergic reactions during a follow‐up period of 282 patient‐years (incidence rate: 1.4/100 patients/y; 95% CI: 0.64‐2.04). Twelve children experienced 19 anaphylaxis reactions including five requiring PICU admission (anaphylaxis recurrence rate: 0.20/100 patients/y; 95% CI non‐calculable). Food was the trigger for 79% of recurrent reactions and drugs for 8%. The food trigger was previously known in 83%, the same as the index trigger in 69%. Overall, 1.5% of the recurrent reactions were treated with adrenaline injection and 8% an emergency hospital admission. Patients with recurrence had more likely a history of food allergy (P |
| doi_str_mv | 10.1111/pai.13015 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02266019v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2216213513</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3875-ea5ce8ceedbe779ad7cd71ad96409420bf54873c4092297cfb1f2ef2658755443</originalsourceid><addsrcrecordid>eNp1kc9uFDEMxiMEokvhwAugSFzgMG2cTJIJt1VF_0grwQFuSFE241FTZpMh2WnZG4_AM_IkTdlSJCR8sWz9_NnWR8hLYEdQ43hy4QgEA_mILEAY0wgmusdkwQyTjQKpD8izUq4YAy0UPCUHgsnOtIovyJdldNPlbnTfQ6Gu34RSQoqFhkgn7IPb5uBrscVYwjVS7zLSOYZteUdP0zimm18_fs4TdbGnOZSvNA00o59zxujxOXkyuLHgi_t8SD6fvv90ct6sPpxdnCxXjRedlg066bHziP0atTau177X4HqjWmZaztaDbDstfK04N9oPaxg4DlzJOi3bVhySt3vdSzfaKYeNyzubXLDny5W96zHOlWJgrqGyb_bslNO3GcvW1p89jqOLmOZiOShgSkhjKvr6H_QqzTnWTyyvGAchQfxd7nMqJePwcAEwe2ePrfbY3_ZU9tW94rzeYP9A_vGjAsd74CaMuPu_kv24vNhL3gKWrJkK</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2216213513</pqid></control><display><type>article</type><title>Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Pouessel, Guillaume ; Cerbelle, Valentine ; Lejeune, Stephanie ; Leteurtre, Stephane ; Ramdane, Nassima ; Deschildre, Antoine ; Tourneux, P ; Boussicault, G ; Thiriez, G ; Brissaud, O ; Garenne, A ; Jokic, M ; Petit, I ; Semama, D ; Bergounioux, J ; Debillon, T ; Wroblewski, I ; Dorkenoo Morgan, RA ; Mallet, E ; Javouhey, E ; Vanel, B ; Vialet, R ; Michel, F ; Cambonie, G ; Milesi, C ; Boussard, N ; Joram, N ; Dupont, D ; Tissières, P ; Dauger, S ; Renolleau, S ; Leger, PL ; Mansir, T ; Saulnier, JP ; Bednarek, N ; Tirel, O ; Blanc, T ; Patural, H ; Astruc, D ; Marcoux, MO ; Amadieu, R ; Chantreuil, J</creator><creatorcontrib>Pouessel, Guillaume ; Cerbelle, Valentine ; Lejeune, Stephanie ; Leteurtre, Stephane ; Ramdane, Nassima ; Deschildre, Antoine ; Tourneux, P ; Boussicault, G ; Thiriez, G ; Brissaud, O ; Garenne, A ; Jokic, M ; Petit, I ; Semama, D ; Bergounioux, J ; Debillon, T ; Wroblewski, I ; Dorkenoo Morgan, RA ; Mallet, E ; Javouhey, E ; Vanel, B ; Vialet, R ; Michel, F ; Cambonie, G ; Milesi, C ; Boussard, N ; Joram, N ; Dupont, D ; Tissières, P ; Dauger, S ; Renolleau, S ; Leger, PL ; Mansir, T ; Saulnier, JP ; Bednarek, N ; Tirel, O ; Blanc, T ; Patural, H ; Astruc, D ; Marcoux, MO ; Amadieu, R ; Chantreuil, J ; French Group for Pediatric Intensive Care Emergencies (GFRUP) ; the French Group for Pediatric Intensive Care Emergencies (GFRUP)</creatorcontrib><description>Background
Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow‐up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.
Methods
We conducted a telephone survey of 166 children (≤18 years) hospitalized from 2003 to 2013.
Results
In all, 106 (64%) completed the survey (boys, 59%; mean age [SD]: 15.3 years [5.5]). The main index triggers were drugs (45%) and foods (37%). The mean duration follow‐up was of 7.7 years (SD: 2.4). Thirty‐eight (36%) children experienced 399 new allergic reactions during a follow‐up period of 282 patient‐years (incidence rate: 1.4/100 patients/y; 95% CI: 0.64‐2.04). Twelve children experienced 19 anaphylaxis reactions including five requiring PICU admission (anaphylaxis recurrence rate: 0.20/100 patients/y; 95% CI non‐calculable). Food was the trigger for 79% of recurrent reactions and drugs for 8%. The food trigger was previously known in 83%, the same as the index trigger in 69%. Overall, 1.5% of the recurrent reactions were treated with adrenaline injection and 8% an emergency hospital admission. Patients with recurrence had more likely a history of food allergy (P < 10−4), asthma (P < 0.005), atopic dermatitis (P < 0.05) than those without. 31% of the 50 children with food allergy did not see an allergist, 23% had no adrenaline auto‐injector, and 26% lacked a school individual healthcare plan.
Conclusions
Following a PICU admission for anaphylaxis, recurrence is high in children with food allergy compared with drug allergy. Allergic comorbidities increase the risk. Medical follow‐up has to be improved for these at‐risk children.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/pai.13015</identifier><identifier>PMID: 30589462</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Adolescent ; Anaphylaxis ; Anaphylaxis - epidemiology ; Anaphylaxis - etiology ; Asthma ; Atopic dermatitis ; Child ; Child, Preschool ; Children ; Dermatitis ; drug ; Emergency medical services ; Epinephrine ; Female ; Follow-Up Studies ; Food allergies ; food allergy ; France - epidemiology ; Hospitalization - statistics & numerical data ; Humans ; Incidence ; Intensive care ; intensive care unit ; Intensive care units ; Intensive Care Units, Pediatric - statistics & numerical data ; Life Sciences ; Male ; mortality ; Patients ; Pediatrics ; Recurrence ; Retrospective Studies ; Risk Factors ; Santé publique et épidémiologie ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Pediatric allergy and immunology, 2019-05, Vol.30 (3), p.341-347</ispartof><rights>2019 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.</rights><rights>Copyright © 2019 John Wiley & Sons A/S</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3875-ea5ce8ceedbe779ad7cd71ad96409420bf54873c4092297cfb1f2ef2658755443</citedby><cites>FETCH-LOGICAL-c3875-ea5ce8ceedbe779ad7cd71ad96409420bf54873c4092297cfb1f2ef2658755443</cites><orcidid>0000-0001-7009-2113 ; 0000-0003-0900-588X ; 0000-0003-2006-7221 ; 0000-0002-6480-0758</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpai.13015$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpai.13015$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,777,781,882,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30589462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02266019$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Pouessel, Guillaume</creatorcontrib><creatorcontrib>Cerbelle, Valentine</creatorcontrib><creatorcontrib>Lejeune, Stephanie</creatorcontrib><creatorcontrib>Leteurtre, Stephane</creatorcontrib><creatorcontrib>Ramdane, Nassima</creatorcontrib><creatorcontrib>Deschildre, Antoine</creatorcontrib><creatorcontrib>Tourneux, P</creatorcontrib><creatorcontrib>Boussicault, G</creatorcontrib><creatorcontrib>Thiriez, G</creatorcontrib><creatorcontrib>Brissaud, O</creatorcontrib><creatorcontrib>Garenne, A</creatorcontrib><creatorcontrib>Jokic, M</creatorcontrib><creatorcontrib>Petit, I</creatorcontrib><creatorcontrib>Semama, D</creatorcontrib><creatorcontrib>Bergounioux, J</creatorcontrib><creatorcontrib>Debillon, T</creatorcontrib><creatorcontrib>Wroblewski, I</creatorcontrib><creatorcontrib>Dorkenoo Morgan, RA</creatorcontrib><creatorcontrib>Mallet, E</creatorcontrib><creatorcontrib>Javouhey, E</creatorcontrib><creatorcontrib>Vanel, B</creatorcontrib><creatorcontrib>Vialet, R</creatorcontrib><creatorcontrib>Michel, F</creatorcontrib><creatorcontrib>Cambonie, G</creatorcontrib><creatorcontrib>Milesi, C</creatorcontrib><creatorcontrib>Boussard, N</creatorcontrib><creatorcontrib>Joram, N</creatorcontrib><creatorcontrib>Dupont, D</creatorcontrib><creatorcontrib>Tissières, P</creatorcontrib><creatorcontrib>Dauger, S</creatorcontrib><creatorcontrib>Renolleau, S</creatorcontrib><creatorcontrib>Leger, PL</creatorcontrib><creatorcontrib>Mansir, T</creatorcontrib><creatorcontrib>Saulnier, JP</creatorcontrib><creatorcontrib>Bednarek, N</creatorcontrib><creatorcontrib>Tirel, O</creatorcontrib><creatorcontrib>Blanc, T</creatorcontrib><creatorcontrib>Patural, H</creatorcontrib><creatorcontrib>Astruc, D</creatorcontrib><creatorcontrib>Marcoux, MO</creatorcontrib><creatorcontrib>Amadieu, R</creatorcontrib><creatorcontrib>Chantreuil, J</creatorcontrib><creatorcontrib>French Group for Pediatric Intensive Care Emergencies (GFRUP)</creatorcontrib><creatorcontrib>the French Group for Pediatric Intensive Care Emergencies (GFRUP)</creatorcontrib><title>Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>Background
Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow‐up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.
Methods
We conducted a telephone survey of 166 children (≤18 years) hospitalized from 2003 to 2013.
Results
In all, 106 (64%) completed the survey (boys, 59%; mean age [SD]: 15.3 years [5.5]). The main index triggers were drugs (45%) and foods (37%). The mean duration follow‐up was of 7.7 years (SD: 2.4). Thirty‐eight (36%) children experienced 399 new allergic reactions during a follow‐up period of 282 patient‐years (incidence rate: 1.4/100 patients/y; 95% CI: 0.64‐2.04). Twelve children experienced 19 anaphylaxis reactions including five requiring PICU admission (anaphylaxis recurrence rate: 0.20/100 patients/y; 95% CI non‐calculable). Food was the trigger for 79% of recurrent reactions and drugs for 8%. The food trigger was previously known in 83%, the same as the index trigger in 69%. Overall, 1.5% of the recurrent reactions were treated with adrenaline injection and 8% an emergency hospital admission. Patients with recurrence had more likely a history of food allergy (P < 10−4), asthma (P < 0.005), atopic dermatitis (P < 0.05) than those without. 31% of the 50 children with food allergy did not see an allergist, 23% had no adrenaline auto‐injector, and 26% lacked a school individual healthcare plan.
Conclusions
Following a PICU admission for anaphylaxis, recurrence is high in children with food allergy compared with drug allergy. Allergic comorbidities increase the risk. Medical follow‐up has to be improved for these at‐risk children.</description><subject>Adolescent</subject><subject>Anaphylaxis</subject><subject>Anaphylaxis - epidemiology</subject><subject>Anaphylaxis - etiology</subject><subject>Asthma</subject><subject>Atopic dermatitis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Dermatitis</subject><subject>drug</subject><subject>Emergency medical services</subject><subject>Epinephrine</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Food allergies</subject><subject>food allergy</subject><subject>France - epidemiology</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care</subject><subject>intensive care unit</subject><subject>Intensive care units</subject><subject>Intensive Care Units, Pediatric - statistics & numerical data</subject><subject>Life Sciences</subject><subject>Male</subject><subject>mortality</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Santé publique et épidémiologie</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9uFDEMxiMEokvhwAugSFzgMG2cTJIJt1VF_0grwQFuSFE241FTZpMh2WnZG4_AM_IkTdlSJCR8sWz9_NnWR8hLYEdQ43hy4QgEA_mILEAY0wgmusdkwQyTjQKpD8izUq4YAy0UPCUHgsnOtIovyJdldNPlbnTfQ6Gu34RSQoqFhkgn7IPb5uBrscVYwjVS7zLSOYZteUdP0zimm18_fs4TdbGnOZSvNA00o59zxujxOXkyuLHgi_t8SD6fvv90ct6sPpxdnCxXjRedlg066bHziP0atTau177X4HqjWmZaztaDbDstfK04N9oPaxg4DlzJOi3bVhySt3vdSzfaKYeNyzubXLDny5W96zHOlWJgrqGyb_bslNO3GcvW1p89jqOLmOZiOShgSkhjKvr6H_QqzTnWTyyvGAchQfxd7nMqJePwcAEwe2ePrfbY3_ZU9tW94rzeYP9A_vGjAsd74CaMuPu_kv24vNhL3gKWrJkK</recordid><startdate>201905</startdate><enddate>201905</enddate><creator>Pouessel, Guillaume</creator><creator>Cerbelle, Valentine</creator><creator>Lejeune, Stephanie</creator><creator>Leteurtre, Stephane</creator><creator>Ramdane, Nassima</creator><creator>Deschildre, Antoine</creator><creator>Tourneux, P</creator><creator>Boussicault, G</creator><creator>Thiriez, G</creator><creator>Brissaud, O</creator><creator>Garenne, A</creator><creator>Jokic, M</creator><creator>Petit, I</creator><creator>Semama, D</creator><creator>Bergounioux, J</creator><creator>Debillon, T</creator><creator>Wroblewski, I</creator><creator>Dorkenoo Morgan, RA</creator><creator>Mallet, E</creator><creator>Javouhey, E</creator><creator>Vanel, B</creator><creator>Vialet, R</creator><creator>Michel, F</creator><creator>Cambonie, G</creator><creator>Milesi, C</creator><creator>Boussard, N</creator><creator>Joram, N</creator><creator>Dupont, D</creator><creator>Tissières, P</creator><creator>Dauger, S</creator><creator>Renolleau, S</creator><creator>Leger, PL</creator><creator>Mansir, T</creator><creator>Saulnier, JP</creator><creator>Bednarek, N</creator><creator>Tirel, O</creator><creator>Blanc, T</creator><creator>Patural, H</creator><creator>Astruc, D</creator><creator>Marcoux, MO</creator><creator>Amadieu, R</creator><creator>Chantreuil, J</creator><general>Wiley Subscription Services, Inc</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-7009-2113</orcidid><orcidid>https://orcid.org/0000-0003-0900-588X</orcidid><orcidid>https://orcid.org/0000-0003-2006-7221</orcidid><orcidid>https://orcid.org/0000-0002-6480-0758</orcidid></search><sort><creationdate>201905</creationdate><title>Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence</title><author>Pouessel, Guillaume ; Cerbelle, Valentine ; Lejeune, Stephanie ; Leteurtre, Stephane ; Ramdane, Nassima ; Deschildre, Antoine ; Tourneux, P ; Boussicault, G ; Thiriez, G ; Brissaud, O ; Garenne, A ; Jokic, M ; Petit, I ; Semama, D ; Bergounioux, J ; Debillon, T ; Wroblewski, I ; Dorkenoo Morgan, RA ; Mallet, E ; Javouhey, E ; Vanel, B ; Vialet, R ; Michel, F ; Cambonie, G ; Milesi, C ; Boussard, N ; Joram, N ; Dupont, D ; Tissières, P ; Dauger, S ; Renolleau, S ; Leger, PL ; Mansir, T ; Saulnier, JP ; Bednarek, N ; Tirel, O ; Blanc, T ; Patural, H ; Astruc, D ; Marcoux, MO ; Amadieu, R ; Chantreuil, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3875-ea5ce8ceedbe779ad7cd71ad96409420bf54873c4092297cfb1f2ef2658755443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adolescent</topic><topic>Anaphylaxis</topic><topic>Anaphylaxis - epidemiology</topic><topic>Anaphylaxis - etiology</topic><topic>Asthma</topic><topic>Atopic dermatitis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Dermatitis</topic><topic>drug</topic><topic>Emergency medical services</topic><topic>Epinephrine</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Food allergies</topic><topic>food allergy</topic><topic>France - epidemiology</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care</topic><topic>intensive care unit</topic><topic>Intensive care units</topic><topic>Intensive Care Units, Pediatric - statistics & numerical data</topic><topic>Life Sciences</topic><topic>Male</topic><topic>mortality</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Recurrence</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Santé publique et épidémiologie</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pouessel, Guillaume</creatorcontrib><creatorcontrib>Cerbelle, Valentine</creatorcontrib><creatorcontrib>Lejeune, Stephanie</creatorcontrib><creatorcontrib>Leteurtre, Stephane</creatorcontrib><creatorcontrib>Ramdane, Nassima</creatorcontrib><creatorcontrib>Deschildre, Antoine</creatorcontrib><creatorcontrib>Tourneux, P</creatorcontrib><creatorcontrib>Boussicault, G</creatorcontrib><creatorcontrib>Thiriez, G</creatorcontrib><creatorcontrib>Brissaud, O</creatorcontrib><creatorcontrib>Garenne, A</creatorcontrib><creatorcontrib>Jokic, M</creatorcontrib><creatorcontrib>Petit, I</creatorcontrib><creatorcontrib>Semama, D</creatorcontrib><creatorcontrib>Bergounioux, J</creatorcontrib><creatorcontrib>Debillon, T</creatorcontrib><creatorcontrib>Wroblewski, I</creatorcontrib><creatorcontrib>Dorkenoo Morgan, RA</creatorcontrib><creatorcontrib>Mallet, E</creatorcontrib><creatorcontrib>Javouhey, E</creatorcontrib><creatorcontrib>Vanel, B</creatorcontrib><creatorcontrib>Vialet, 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Group for Pediatric Intensive Care Emergencies (GFRUP)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Pediatric allergy and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pouessel, Guillaume</au><au>Cerbelle, Valentine</au><au>Lejeune, Stephanie</au><au>Leteurtre, Stephane</au><au>Ramdane, Nassima</au><au>Deschildre, Antoine</au><au>Tourneux, P</au><au>Boussicault, G</au><au>Thiriez, G</au><au>Brissaud, O</au><au>Garenne, A</au><au>Jokic, M</au><au>Petit, I</au><au>Semama, D</au><au>Bergounioux, J</au><au>Debillon, T</au><au>Wroblewski, I</au><au>Dorkenoo Morgan, RA</au><au>Mallet, E</au><au>Javouhey, E</au><au>Vanel, B</au><au>Vialet, R</au><au>Michel, F</au><au>Cambonie, G</au><au>Milesi, C</au><au>Boussard, N</au><au>Joram, N</au><au>Dupont, D</au><au>Tissières, P</au><au>Dauger, S</au><au>Renolleau, S</au><au>Leger, PL</au><au>Mansir, T</au><au>Saulnier, JP</au><au>Bednarek, N</au><au>Tirel, O</au><au>Blanc, T</au><au>Patural, H</au><au>Astruc, D</au><au>Marcoux, MO</au><au>Amadieu, R</au><au>Chantreuil, J</au><aucorp>French Group for Pediatric Intensive Care Emergencies (GFRUP)</aucorp><aucorp>the French Group for Pediatric Intensive Care Emergencies (GFRUP)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence</atitle><jtitle>Pediatric allergy and immunology</jtitle><addtitle>Pediatr Allergy Immunol</addtitle><date>2019-05</date><risdate>2019</risdate><volume>30</volume><issue>3</issue><spage>341</spage><epage>347</epage><pages>341-347</pages><issn>0905-6157</issn><eissn>1399-3038</eissn><abstract>Background
Data about the risk of anaphylaxis recurrence in children are lacking. We assessed anaphylaxis recurrence and medical follow‐up in a cohort of children previously hospitalized in a French pediatric intensive care unit (PICU) for anaphylaxis.
Methods
We conducted a telephone survey of 166 children (≤18 years) hospitalized from 2003 to 2013.
Results
In all, 106 (64%) completed the survey (boys, 59%; mean age [SD]: 15.3 years [5.5]). The main index triggers were drugs (45%) and foods (37%). The mean duration follow‐up was of 7.7 years (SD: 2.4). Thirty‐eight (36%) children experienced 399 new allergic reactions during a follow‐up period of 282 patient‐years (incidence rate: 1.4/100 patients/y; 95% CI: 0.64‐2.04). Twelve children experienced 19 anaphylaxis reactions including five requiring PICU admission (anaphylaxis recurrence rate: 0.20/100 patients/y; 95% CI non‐calculable). Food was the trigger for 79% of recurrent reactions and drugs for 8%. The food trigger was previously known in 83%, the same as the index trigger in 69%. Overall, 1.5% of the recurrent reactions were treated with adrenaline injection and 8% an emergency hospital admission. Patients with recurrence had more likely a history of food allergy (P < 10−4), asthma (P < 0.005), atopic dermatitis (P < 0.05) than those without. 31% of the 50 children with food allergy did not see an allergist, 23% had no adrenaline auto‐injector, and 26% lacked a school individual healthcare plan.
Conclusions
Following a PICU admission for anaphylaxis, recurrence is high in children with food allergy compared with drug allergy. Allergic comorbidities increase the risk. Medical follow‐up has to be improved for these at‐risk children.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>30589462</pmid><doi>10.1111/pai.13015</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-7009-2113</orcidid><orcidid>https://orcid.org/0000-0003-0900-588X</orcidid><orcidid>https://orcid.org/0000-0003-2006-7221</orcidid><orcidid>https://orcid.org/0000-0002-6480-0758</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0905-6157 |
| ispartof | Pediatric allergy and immunology, 2019-05, Vol.30 (3), p.341-347 |
| issn | 0905-6157 1399-3038 |
| language | eng |
| recordid | cdi_hal_primary_oai_HAL_hal_02266019v1 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adolescent Anaphylaxis Anaphylaxis - epidemiology Anaphylaxis - etiology Asthma Atopic dermatitis Child Child, Preschool Children Dermatitis drug Emergency medical services Epinephrine Female Follow-Up Studies Food allergies food allergy France - epidemiology Hospitalization - statistics & numerical data Humans Incidence Intensive care intensive care unit Intensive care units Intensive Care Units, Pediatric - statistics & numerical data Life Sciences Male mortality Patients Pediatrics Recurrence Retrospective Studies Risk Factors Santé publique et épidémiologie Surveys and Questionnaires Young Adult |
| title | Anaphylaxis admissions in pediatric intensive care units: Follow‐up and risk of recurrence |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A52%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Anaphylaxis%20admissions%20in%20pediatric%20intensive%20care%20units:%20Follow%E2%80%90up%20and%20risk%20of%20recurrence&rft.jtitle=Pediatric%20allergy%20and%20immunology&rft.au=Pouessel,%20Guillaume&rft.aucorp=French%20Group%20for%20Pediatric%20Intensive%20Care%20Emergencies%20(GFRUP)&rft.date=2019-05&rft.volume=30&rft.issue=3&rft.spage=341&rft.epage=347&rft.pages=341-347&rft.issn=0905-6157&rft.eissn=1399-3038&rft_id=info:doi/10.1111/pai.13015&rft_dat=%3Cproquest_hal_p%3E2216213513%3C/proquest_hal_p%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2216213513&rft_id=info:pmid/30589462&rfr_iscdi=true |