Selective Inhibition of Topoisomerase I and Various Steps of Spliceosome Assembly by Diospyrin Derivatives

Pre-mRNA splicing is an essential step of the expression of most metazoan protein-coding genes, which is often regulated in a cell type-specific or developmental manner. We have demonstrated previously that human DNA topoisomerase I, an extensively studied target for anticancer drugs, also has an in...

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Veröffentlicht in:	Molecular pharmacology 2005-04, Vol.67 (4), p.1186-1194
Hauptverfasser:	Tazi, Jamal, Bakkour, Nadia, Soret, Johann, Zekri, Latifa, Hazra, Banasri, Laine, William, Baldeyrou, Brigitte, Lansiaux, Amélie, Bailly, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry, Molecular Biology DNA - metabolism Enzyme Inhibitors - pharmacology Life Sciences Metazoa Naphthoquinones - pharmacology Phosphorylation RNA Splicing - drug effects Spliceosomes - drug effects Structure-Activity Relationship Topoisomerase I Inhibitors
Online-Zugang:	Volltext
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