Three-dimensional polarization sensitizes hepatocytes to Fas/CD95 apoptotic signalling

Maintenance of epithelial cell shape and polarity determines many vital cell functions, including the appropriate response to external stimuli. Murine hepatocytes cultured in a three-dimensional Matrigel matrix formed highly polarized organoids characterized by specific localization of an ERM (ezrin...

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Veröffentlicht in:	Journal of cell science 2005-06, Vol.118 (Pt 12), p.2763-2773
Hauptverfasser:	Haouzi, Delphine, Baghdiguian, Stephen, Granier, Guillaume, Travo, Pierre, Mangeat, Paul, Hibner, Urszula
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biochemistry, Molecular Biology Cell Line Cell Polarity Collagen Drug Combinations fas Receptor - metabolism Gene Expression Regulation Hepatocytes - cytology Hepatocytes - metabolism Laminin Life Sciences Mice NF-kappa B - metabolism Organoids - metabolism Proteoglycans Signal Transduction
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