The Packaging Signal of MLV is an Integrated Module that Mediates Intracellular Transport of Genomic RNAs

Packaging of MLV genomes requires four cis-acting stem–loops. Stem–loops A and B are self-complementary and bind Gag in their dimeric form, while the C and D elements mediate loop–loop interactions that facilitate RNA dimerization. Packaging also requires nuclear export of viral genomes, and their c...

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